Morphometric study of Schistosoma mansoni adult worms recovered from undernourished infected mice

Oliveira, Sheilla Andrade de; Barbosa, Alynne da Silva; Gomes, Delir Corrêa; Machado-Silva, José Roberto; Barros, Andréia Ferreira de; Neves, Renata Heisler; Coutinho, Eridan M.

doi:10.1590/s0074-02762003000500007

Cited by 16 publications

(11 citation statements)

References 40 publications

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“…Previous investigations on the interactions between the host nutritional status and infection by S. mansoni have called attention to the role of undernutrition on the biology and differentiation of the parasites, inducing phenotypic changes in adult worms of both genders (Ferreira & Coutinho 1999, Neves et al 2002, Oliveira et al 2003), most likely owing to the lack of essential nutrients for their adequate growth and development. Nutritional deficiency also influences the immune response and immunopathology of schistosomiasis in the murine experimental host (Coutinho 2004, Oliveira et al 2004, Coutinho et al 2007, 2010).…”

Section: Discussionmentioning

confidence: 99%

Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni

Barros

Oliveira

Carvalho

et al. 2014

Mem. Inst. Oswaldo Cruz

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Undernourished mice infected (UI) submitted to low and long-lasting infections by Schistosoma mansoni are unable to develop the hepatic periportal fibrosis that is equivalent to Symmers’ fibrosis in humans. In this report, the effects of the host’s nutritional status on parasite (worm load, egg viability and maturation) and host (growth curves, biology, collagen synthesis and characteristics of the immunological response) were studied and these are considered as interdependent factors influencing the amount and distribution of fibrous tissue in hepatic periovular granulomas and portal spaces. The nutritional status of the host influenced the low body weight and low parasite burden detected in UI mice as well as the number, viability and maturation of released eggs. The reduced oviposition and increased number of degenerated or dead eggs were associated with low protein synthesis detected in deficient hosts, which likely induced the observed decrease in transformation growth factor (TGF)-β1 and liver collagen. Despite the reduced number of mature eggs in UI mice, the activation of TGF-β1 and hepatic stellate cells occurred regardless of the unviability of most miracidia, due to stimulation by fibrogenic proteins and eggshell glycoproteins. However, changes in the repair mechanisms influenced by the nutritional status in deficient animals may account for the decreased liver collagen detected in the present study.

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Section: Discussionmentioning

confidence: 99%

Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni

Barros

Oliveira

Carvalho

et al. 2014

Mem. Inst. Oswaldo Cruz

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“…Undernourished and well-nourished mice have similar numbers and sex ratios of worms (unpublished results). However, worms recovered from undernourished infected mice show morphological changes in their internal and external structures and exhibit a low fecundity when compared to parasites recovered from well-nourished hosts (Neves et al 2001;Oliveira et al 2003). In low-protein fed mice, the low fecundity detected in these parasites probably affects the production of eggs and of periovular granulomas, as well as the progression to liver periportal fibrosis (Coutinho et al 1997b).…”

Section: Discussionmentioning

confidence: 99%

Decreased humoral and pathologic responses in undernourished mice infected with Schistosoma mansoni

Oliveira

Silva

Júnior³

et al. 2004

Parasitology Research

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We previously demonstrated that mice subjected to a hypoproteinic diet showed milder chronic lesions on infection with Schistosoma mansoni than normally fed mice. Here we compare the immune response of well-nourished and undernourished mice with chronic S. mansoni infection. The proliferative response and cytokine (IFN-gamma and IL-5) production of splenocytes from undernourished mice against the soluble egg antigen (SEA) of S. mansoni or concanavalin A was similar to that of well-nourished mice. The levels of SEA-specific IgG1, IgG2b and IgG3 antibodies were significantly higher in the sera of well-nourished mice in comparison with undernourished mice. Undernourished animals also exhibited diminished periovular granuloma size compared to well-nourished infected controls. Our results support the importance of host nutritional status in the humoral immune response of mice and its effects on the development of periovular granulomas in malnourished animals infected with S. mansoni.

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“…Vice versa, malnutrition can influence the development of the parasite in its host. In experimental S. mansoni infections, the development of male and female schistosomes has been shown to be impaired in undernourished mice (Oliveira et al 2003;Barros et al 2009), and the scarcity of host micronutrients also affected nematode development and reduced parasitic burden in experimental models such as hamsters (Held et al 2006) or mice (Bourgeois et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Serum CCL11 (eotaxin‐1) and CCL17 (TARC) are serological indicators of multiple helminth infections and are driven by Schistosoma mansoni infection in humans

Geiger

Jardim-Botelho

Williams

et al. 2013

Tropical Med Int Health

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Abstractobjectives To evaluate systemic serum cytokine and chemokine markers for inflammation and Th1/ Th2 responses in relation to multiple helminth infections, parasite burden and/or nutritional status of individuals.methods In a longitudinal study, stool samples from 210 individuals from an area highly endemic for Ascaris lumbricoides, Necator americanus and Schistosoma mansoni were examined before and 12 months after clearance of parasites by chemotherapy. On both occasions, the presence of monoor multiple infections and intensities of infection were compared with nutritional parameters and with serum cytokines or chemokines as markers for inflammatory, regulatory or Th1-or Th2-type immune responses.results Before treatment, we were not able to associate any altered nutritional parameters with increased inflammatory responses, and highest intensities of infection were found in eutrophic participants with multiple infections. In contrast, major changes in serum Th2-type chemokine levels were measured in individuals infected with intestinal helminths and/or S. mansoni, and resulted in significantly higher CCL11 and CCL17 concentrations, both before treatment and after reinfection.conclusions The driving force for these elevated type 2 serum chemokine concentrations was an S. mansoni infection and faecal egg counts significantly correlated with serum IL-10 concentrations.

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Morphometric study of Schistosoma mansoni adult worms recovered from undernourished infected mice

Abstract: Some unfavourable effects of malnutrition of the host on

Cited by 16 publications

References 40 publications

Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni

Low transformation growth factor-β1 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni

Decreased humoral and pathologic responses in undernourished mice infected with Schistosoma mansoni

Serum CCL11 (eotaxin‐1) and CCL17 (TARC) are serological indicators of multiple helminth infections and are driven by Schistosoma mansoni infection in humans

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