Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil

Rabelo-Santos, Sílvia Helena; Zeferino, Luíz Carlos; Villa, Luisa L.; Sobrinho, João P.; Amaral, Rita Goreti; Magalhães, Albino V.

doi:10.1590/s0074-02762003000200003

Cited by 56 publications

(62 citation statements)

References 23 publications

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“…Geographic variations on HPV prevalence and genotype distribution have been described in different regions of the world, including Brazil (20). Thus, it is of utmost importance to conduct regional studies on the prevalence of HPV infection, including the identification and distribution of virus types.…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus infection in women attended at a cervical cancer screening service in Natal, Brazil

Fernandes¹,

Meissner²,

Bezerra³

et al. 2008

Braz. J. Microbiol.

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We analyzed cervical specimens of 202 women, aged 15 to 64 years, attended at Luis Antonio Hospital, Natal, Brazil, to determine the prevalence of HPV and identify the more frequent genotypes and risk factors for HPV infection in women attended at a cervical cancer screening service. Two specimens were collected from each patient: one for cytological examination and the other to detect HPV DNA by PCR, and typing by dot blot hybridization. A total of 54.5% of the sample had normal cytology and 45.5% had cytological alterations. HPV was detected in 24.5% of the cytologically normal women and in 59.8% of those with altered cytology. Both single and double HPV infection increased the likelihood of cytological alterations. Thirteen types of HPV were identified, most of which were high risk. HPV 16 was the most prevalent single-type infection, followed by HPV 58. The most frequent double infection was the association between HPV 56 and 57. The prevalence of HPV in cytologically normal women was greater than that reported for countries on all the continents except Africa. The inverse was observed in women with cytological alterations. The distribution of HPV types was similar to that described for the Americas, with some differences. Multiple sexual partners was the only risk factor showing an association with the presence of HPV infection.

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Section: Introductionmentioning

confidence: 99%

Human papillomavirus infection in women attended at a cervical cancer screening service in Natal, Brazil

Fernandes¹,

Meissner²,

Bezerra³

et al. 2008

Braz. J. Microbiol.

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“…O HPV-18 é o segundo tipo mais prevalente nas regiões Norte, Sudeste e Sul (PEREIRA et al, 2007;RABELO-SANTOS et al, 2003), e já foi descrito como o menos frequente em um estudo no Nordeste do país, onde os autores descreveram que esse resultado podia estar relacionado à amostra predominantemente composta por citologias negativas, e sabe-se que esse tipo é altamente detectado em lesões cervicais (BRUNO et al, 2014;BZHALAVA et al, 2013). Os HPV-16 e o HPV-18 são responsáveis por 50% a 55% dos casos de lesões de alto grau e em torno de 70% do casos de câncer cervical, tanto na América do Sul, quanto no Brasil (FEDRIZZI, 2011).…”

Section: Prevalência Do Hpvunclassified

“…Os HPV-31 e HPV-33 são mais frequentes no Nordeste e Centro-Oeste depois do HPV-16 (OLIVEIRA et al, 2013;RABELO-SANTOS et al, 2003;SANTOS et al, 2013).…”

Section: Prevalência Do Hpvunclassified

“…O HPV-18 é detectado com alta frequência na população (BRITO et al, 2002;PEREIRA et al, 2007;RABELO-SANTOS et al, 2003;SILVA et al, 2009). Considerando que os tipos virais HPV-31 e HPV-33 são bastante frequentes no Nordeste e Centro-Oeste (OLIVEIRA et al, 2013;RABELO-SANTOS et al, 2003;SANTOS et al, 2013), iniciadores para esses tipos também foram inseridos.…”

Section: Presença Do Hpv Nos Três Sítios De Infeçãounclassified

“…A citologia oncótica vem sofrendo uma série de críticas devido aos índices de resultados falso-negativos, que variam de 5% a 70%, e de falso-positivos, 10% a 30% de acordo com Santos et al, (2003). Outros autores consideram que essa variação ocorre em torno de 15% a 50% para os resultados falso-negativos e, em média, 10% para falso-positivos (ALTIOK, 2003;CAVALCANTI;CARESTIATO, 2006;FARTHING et al, 1994).…”

Section: Análises Dos Achados Citológicos Na Mucosa Cervical E Mucosaunclassified

See 2 more Smart Citations

Atividade mucosotrópica do Papilomavírus Humano (HPV) no processo carcinogênico em diferentes sítios de infecção.

Sant’Ana¹

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High prevalence of human papillomavirus type 58 in patients with cervical pre‐malignant lesions in southern Brazil

Paesi

Serafini

Barea

et al. 2009

Journal of Medical Virology

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Cervical cancer is the second most common type of cancer in women worldwide. Several human papillomavirus (HPV) genotypes, sexual behavior, and socioeconomic profile represent major risk factors for the development of this carcinoma. Cervical invasive cancer is preceded by cellular abnormalities that can be identified by cytological or histological exams. In order to determine the prevalence and genotypes of HPV in women with abnormal cytology or histopathology, cervical cell samples from 256 patients were evaluated for the presence of HPV/DNA by polymerase chain reaction (PCR), followed by virus genotyping by restriction fragment length polymorphism (RFLP). A total of 113 samples (51.2%) were HPV/DNA positive. Viral genotyping showed that the most prevalent genotypes were HPV 16 (34.7%) and 58 (13.8%), followed by HPV 33 (9.72%), 11 (8.33%), 18 (5.55%), 53 (5.55%), and 6 (4.2%). Four samples (5.55%) exhibited multiple infections due to the great similarity of socioeconomic characteristics and sexual behavior of HPV positive women, it was not possible to establish a risk profile for female HPV infection.

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Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiânia, Brazil

Abstract: This study estimated the prevalence and distribution of human papillomavirus (HPV) types among women with cervical intraepithelial neoplasia (CIN) grade III and invasive cervical cancer from Goiás (Brazil Central Region 16, 18, 31, 33, 45, 54, 6/11, 42/43/44, 51/52, 56/ 58

Cited by 56 publications

References 23 publications

Human papillomavirus infection in women attended at a cervical cancer screening service in Natal, Brazil

Human papillomavirus infection in women attended at a cervical cancer screening service in Natal, Brazil

Atividade mucosotrópica do Papilomavírus Humano (HPV) no processo carcinogênico em diferentes sítios de infecção.

High prevalence of human papillomavirus type 58 in patients with cervical pre‐malignant lesions in southern Brazil

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