Pseudomonas aeruginosa: study of Antibiotic Resistance and Molecular Typing in Hospital Infection Cases in a Neonatal Intensive Care Unit from Rio de Janeiro City, Brazil

Loureiro, Marcio Martins; Moraes, Bianca Aguiar de; Mendonça, V. L. F.; Quadra, M. R. R.; Pinheiro, G. S.; Asensi, Marise Dutra

doi:10.1590/s0074-02762002000300020

Cited by 26 publications

(31 citation statements)

References 28 publications

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“…(Garcia et al, 1989;Garland et al, 1996;Muyldermans et al, 1998;Gras-Le Guen et al, 2003;Majumdar et al, 2004;Schutze et al, 2004;Zabel et al, 2004;Crivaro et al, 2009;Sánchez-Carrillo et al, 2009;Naze et al, 2010). The overall mean prevalence of colonization or infection reported from eight studies (Archibald et al, 1998;Muyldermans et al, 1998;Foca et al, 2000;Moolenaar et al, 2000;Loureiro et al, 2002;Crivaro et al, 2009;Sánchez-Carrillo et al, 2009;Naze et al, 2010), which included information on the number of unaffected individuals, was 18.5 % (range 10.5-42 %). For the studies that reported infection and colonization separately, the mean percentage of infections occurring in populations who had been colonized by the organism, calculated as n infected /n infected +n colonized , was 22 % (range 4.8-75 %).…”

Section: Resultsmentioning

confidence: 99%

“…However, two studies were excluded after inspection of the full-text documents, both describing prospective studies; Mammina et al (2008) described investigation of colonization by antibiotic-resistant P. aeruginosa but did not describe an outbreak of P. aeruginosa infection or state that this work followed such an outbreak and Mammina et al (2008) and Hu et al (2010) described prospective surveillance of P. aeruginosa colonization among mechanically ventilated neonates. Therefore, 15 studies (Garcia et al, 1989;Verweij et al, 1993;Garland et al, 1996;Archibald et al, 1998;Muyldermans et al, 1998;Foca et al, 2000;Moolenaar et al, 2000;Loureiro et al, 2002;Gras-Le Guen et al, 2003;Majumdar et al, 2004;Schutze et al, 2004;Zabel et al, 2004;Crivaro et al, 2009;Sánchez-Carrillo et al, 2009;Naze et al, 2010) were reviewed using 18 ORION criteria (Stone et al, 2007). Of these studies, six (Loureiro et al, 2002;Gras-Le Guen et al, 2003;Zabel et al, 2004;Crivaro et al, 2009;Sánchez-Carrillo et al, 2009;and Naze et al, 2010) were not mentioned in the original review by Simon et al, (2008).…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, 15 studies (Garcia et al, 1989;Verweij et al, 1993;Garland et al, 1996;Archibald et al, 1998;Muyldermans et al, 1998;Foca et al, 2000;Moolenaar et al, 2000;Loureiro et al, 2002;Gras-Le Guen et al, 2003;Majumdar et al, 2004;Schutze et al, 2004;Zabel et al, 2004;Crivaro et al, 2009;Sánchez-Carrillo et al, 2009;Naze et al, 2010) were reviewed using 18 ORION criteria (Stone et al, 2007). Of these studies, six (Loureiro et al, 2002;Gras-Le Guen et al, 2003;Zabel et al, 2004;Crivaro et al, 2009;Sánchez-Carrillo et al, 2009;and Naze et al, 2010) were not mentioned in the original review by Simon et al, (2008). The outbreaks reported in the 15 studies occurred between 1986 and 2003.…”

Section: Resultsmentioning

confidence: 99%

“…In total, 414 infants were colonized or infected with P. aeruginosa (Table S1, available in JMM Online). Three studies considered cases of infection only (Verweij et al, 1993;Archibald et al, 1998;Loureiro et al, 2002), two studies did not differentiate between colonization and infection (Foca et al, 2000;Moolenaar et al, 2000) and 10 studies reported infection and colonization separately. (Garcia et al, 1989;Garland et al, 1996;Muyldermans et al, 1998;Gras-Le Guen et al, 2003;Majumdar et al, 2004;Schutze et al, 2004;Zabel et al, 2004;Crivaro et al, 2009;Sánchez-Carrillo et al, 2009;Naze et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

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Pseudomonas aeruginosa outbreaks in the neonatal intensive care unit – a systematic review of risk factors and environmental sources

Jefferies

Cooper

Yam

et al. 2012

Journal of Medical Microbiology

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Pseudomonas aeruginosa is a Gram-negative bacterium commonly occurring in soil and water. It is an opportunistic pathogen and an important cause of healthcare-associated infections, particularly among infants in neonatal intensive care units (NICUs). Several reports regarding outbreaks of P. aeruginosa in NICUs have been published. MEDLINE and EMBASE databases were searched using the MeSH terms [Pseudomonas aeruginosa], [Outbreak OR Infection OR bacteraemia, OR sepsis OR disease] and [Neonat* OR baby OR babies OR newborn*]. Fifteen studies describing a total of 414 infants colonized or infected with P. aeruginosa were reviewed. The mean percentage of infections occurring in the populations that had been colonized by the organism (calculated as n infected /n infected +n colonized ) was 22 %. Environmental sampling was performed in 14 studies, nine of which detected P. aeruginosa. The risk factors identified were antimicrobial drug use and the number of days of antimicrobial therapy prescribed before positive blood culture, exposure to particular healthcare workers (HCW), transfusion of blood products, and intravenous delivery of nutrients/electrolytes. Exposure to umbilical venous catheters was associated with bloodstream infections. Increasing age and use of artificial fingernails were risk factors for colonization of hands of HCWs. Low birth weight pre-term infants were at greater risk of mortality from P. aeruginosa infection than older infants. BackgroundPseudomonas aeruginosa is a Gram-negative bacterium commonly occurring in soil and water. It is an opportunistic pathogen, causing disease in vulnerable individuals, such as the immunocompromised, those where host defences have been breached, such as burns patients, and infants in whom the immune system is not yet developed. Most commonly, P. aeruginosa infections occur in the urinary tract, in burn wounds and as chronic lung infections in cystic-fibrosis patients. However, the organism is also an important cause of healthcare-associated infections, particularly among infants in neonatal intensive care units (NICUs) (Jarvis et al., 1987) owing to their underdeveloped immune system and the fact that such infants are often intubated, catheterized with intravascular catheters/devices in-situ, and/or receiving parenteral nutrition, which may increase risk of infection (Gaynes et al., 2005). Unfortunately, such infections in neonates can be fatal, as was the case in a recent UK outbreak in which four babies died (Wise, 2012). The ubiquitous nature of P. aeruginosa in the environment makes the sources of such outbreaks difficult to identify.Several outbreaks of P. aeruginosa colonization and infection in NICUs have been published. Simon et al. (2008) published a systematic review of confirmed outbreaks in both neonatal and paediatric patients that were identified using the PubMed database and the web-based register for nosocomial outbreaks. That review did not search for reports of outbreaks listed in the Embase database and so may have been biased by the omission ...

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Pseudomonas aeruginosa outbreaks in the neonatal intensive care unit – a systematic review of risk factors and environmental sources

Jefferies

Cooper

Yam

et al. 2012

Journal of Medical Microbiology

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“…Controlling resistant bacteria is an increasingly challenging endeavor and is a major concern for specialists around the world. [3][4][5][6] The introduction of new antibiotics therefore became a matter of public health. Fortunately, research in this area is widespread, and, as for cancer, natural products can be considered one of the main sources of new drugs.…”

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confidence: 99%

Discovery of New Antitumoral and Antibacterial Drugs From Brazilian Plant Extracts Using High Throughput Screening

Younes

Varella

Suffredini

2007

Clinics

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Younes RN, Varella AD, Suffredini IB. Discovery of new antitumoral and antibacterial drugs from brazilian plant extracts using high throughput screening. Clinics. 2007;62(6):763-8.Plants have played a significant role in the treatment of cancer and infectious diseases for the last four decades. The discovery and introduction to market of paclitaxel, the vinca alkaloids, etoposide, and many antibacterial drugs support drug discovery programs based on natural products. Natural products have been rediscovered as important tools for drug development despite advances in combinatorial chemistry, due to the complex molecular structures able to interact with mammalian cell targets. The Brazilian flora, the most diverse in the world, has become an interesting spot to prospect for new chemical leads or hits due to its species diversity and associated chemical richness. Screening programs have been established in Brazil as a strategy to identify potentially active substances. High throughput screening techniques allow for the analysis of large numbers of extracts in a relatively short period of time, and can be considered one of the most efficient ways of finding new leads from natural products. An updated review of the current status of the biological screening program is presented and recent results from new antitumoral and antibacterial chemical leads are discussed.

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Carbapenem-Resistant Pseudomonas aeruginosa in Chronic Lung Infection: Current Resistance Profile and Hypermutability in Patients with Cystic Fibrosis

et al. 2021

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Pseudomonas aeruginosa: study of Antibiotic Resistance and Molecular Typing in Hospital Infection Cases in a Neonatal Intensive Care Unit from Rio de Janeiro City, Brazil

Cited by 26 publications

References 28 publications

Pseudomonas aeruginosa outbreaks in the neonatal intensive care unit – a systematic review of risk factors and environmental sources

Pseudomonas aeruginosa outbreaks in the neonatal intensive care unit – a systematic review of risk factors and environmental sources

Discovery of New Antitumoral and Antibacterial Drugs From Brazilian Plant Extracts Using High Throughput Screening

Carbapenem-Resistant Pseudomonas aeruginosa in Chronic Lung Infection: Current Resistance Profile and Hypermutability in Patients with Cystic Fibrosis

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