The yellow fever 17D vaccine virus as a vector for the expression of foreign proteins: development of new live flavivirus vaccines

Bonaldo, Myrna C.; Caufour, Philippe; Freire, Marcos S.; Galler, Ricardo

doi:10.1590/s0074-02762000000700037

Cited by 11 publications

(7 citation statements)

References 60 publications

(34 reference statements)

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“…In fact, we observed higher titers of neutralizing antibodies and anti- YF total IgG in C57BL/6 mice after 17D immunization. For recombinant YF 17D viruses, it was not possible to see differences in neutralizing antibody production between the two lineages, maybe due to their over attenuation as compared to parental 17D virus [16,68,69]. The loss in fitness could lead to lower viral spread inside the lymph nodes and less virus coming to B cell zone.…”

Section: Discussionmentioning

confidence: 99%

Early IFN-Gamma Production after YF 17D Vaccine Virus Immunization in Mice and Its Association with Adaptive Immune Responses

et al. 2013

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Yellow Fever vaccine is one of the most efficacious human vaccines ever made. The vaccine (YF 17D) virus induces polyvalent immune responses, with a mixed TH1/TH2 CD4+ cell profile, which results in robust T CD8+ responses and high titers of neutralizing antibody. In recent years, it has been suggested that early events after yellow fever vaccination are crucial to the development of adequate acquired immunity. We have previously shown that primary immunization of humans and monkeys with YF 17D virus vaccine resulted in the early synthesis of IFN-γ. Herein we have demonstrated, for the first time that early IFN-γ production after yellow fever vaccination is a feature also of murine infection and is much more pronounced in the C57BL/6 strain compared to the BALB/c strain. Likewise, in C57BL/6 strain, we have observed the highest CD8+ T cells responses as well as higher titers of neutralizing antibodies and total anti-YF IgG. Regardless of this intense IFN-γ response in mice, it was not possible to see higher titers of IgG2a in relation to IgG1 in both mice lineages. However, IgG2a titers were positively correlated to neutralizing antibodies levels, pointing to an important role of IFN-γ in eliciting high quality responses against YF 17D, therefore influencing the immunogenicity of this vaccine.

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Section: Discussionmentioning

confidence: 99%

Early IFN-Gamma Production after YF 17D Vaccine Virus Immunization in Mice and Its Association with Adaptive Immune Responses

et al. 2013

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“…Subsequent studies confirmed the primacy of the mutated E of SA-14-14-2 in determining its attenuated phenotype [14,15]. It should be noted that YF-17D vaccine which was also generated by nearly 300 sequential passages in cell lines [16] carried the maximum number of 8 of the 22 amino acid substitutions relative to its virulent parent, in its E protein that are believed to be responsible for its attenuation [17]. Non-human primates vaccinated subcutaneously with Chimerivax-JE survived an intra-cerebral challenge from virulent JEV [18] attesting to its impressive safety profile.…”

Section: Inactivated Je Vaccinesmentioning

confidence: 87%

Japanese Encephalitis Vaccines

Satchidanandam

2020

Curr Treat Options Infect Dis

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“…The classical live-attenuated vaccines were generated by continuous passaging of the virus in cell culture or animal tissue to accumulate various mutations, finally achieving the aim of significant attenuation but immunogenicity in vivo . The admirable example is the YF-17D vaccine, which was developed by 176 passages of the Asibi strain in mouse embryo tissue and chicken embryo tissue, which markedly reduced its viscerotropism and neurotropism [77] . However, this traditional method is usually time consuming; it is unpredictable whether the obtained viruses are attenuated and still can elicit protective immunity.…”

Section: Rational Vaccine Design Targeting Capsid Proteinmentioning

confidence: 99%

The role of capsid in the flaviviral life cycle and perspectives for vaccine development

Wang

Chen

et al. 2020

Vaccine

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Highlights The structure and function of flaviviral capsid are very flexible. The capsid gene contains conserved RNA secondary structures. Both steps of assembly and dissociation of nucleocapsid complexes are obscure. Capsid mutant viruses are highly attenuated and immunogenic. ΔC-replicon and single-round infectious particles are promising vaccine approaches.

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The yellow fever 17D vaccine virus as a vector for the expression of foreign proteins: development of new live flavivirus vaccines

Cited by 11 publications

References 60 publications

Early IFN-Gamma Production after YF 17D Vaccine Virus Immunization in Mice and Its Association with Adaptive Immune Responses

Early IFN-Gamma Production after YF 17D Vaccine Virus Immunization in Mice and Its Association with Adaptive Immune Responses

Japanese Encephalitis Vaccines

The role of capsid in the flaviviral life cycle and perspectives for vaccine development

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