Human immunodeficiency virus/acquired immunodeficiency syndrome and tropical diseases: a Brazilian perspective

Morgado, Mariza G.; Barcellos, Christovam; Pina, Maria de FÆtima; Bastos, Francisco

doi:10.1590/s0074-02762000000700024

Cited by 26 publications

(23 citation statements)

References 38 publications

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“…In theory, once this is established, mainly by the medications of the HAART in the control of the viral replication and recovering the immunological system, the Chagas disease should follow its natural course as in the immunocompetent individual. For the other infectious diseases associated to the HIV infection this seems to occur 8,50 . However, the few cases already reported about the co-infection Chagas/HIV/AIDS and the incomplete information about the antiretroviral treatment, as drug specifications, length of use, compliance with treatment, intolerance, side effects, response of the patient to the immunological recovery, makes it difficult to establish in this revision the real impact of this treatment on the reactivation of Chagas disease in co-infected patients.…”

Section: Casesmentioning

confidence: 99%

Co-infection Trypanosoma cruzi/HIV: systematic review (1980 - 2010)

Almeida

Ramos

Correia

et al. 2011

Rev. Soc. Bras. Med. Trop.

114

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Introduction:The co-infection Trypanosoma cruzi/HIV has been described as a clinical event of great relevance. The objective of this study was to describe clinical and epidemiological aspects published in literature. Methods: It is a systematic review of a descriptive nature from the databases Medline, Lilacs, SciELO, Scopus, from 1980 to 2010. Results: There were 83 articles (2.8 articles/year) with a total of 291 cases. The co-infection was described in 1980 and this situation has become the defining AIDS clinical event in Brazil. This is the country with the highest number of publication (51.8%) followed by Argentina (27.7%). The majority of cases are amongst adult men (65.3%) native or from endemic regions with serological diagnosis in the chronic stage (97.9%) and indeterminate form (50.8%). Both diseases follow the normal course, but in 41% the reactivation of the Chagas disease occurs. The most severe form is the meningoencephalitis, with 100% of mortality without specific and early treatment of the T. cruzi. The medication of choice was the benznidazole on doses and duration normally used for the acute phase. The high parasitemia detected by direct or indirect quantitative methods indicated reactivation and its elevation is the most important predictive factor. The lower survival rate was related to the reactivation of the Chagas disease and the natural complications of both diseases. The role of the antiretroviral treatment on the co-infection cannot yet be defined by the knowledge currently existent. Conclusions: Despite the relevance of this clinical event there are still gaps to be filled.

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Section: Casesmentioning

confidence: 99%

Co-infection Trypanosoma cruzi/HIV: systematic review (1980 - 2010)

Almeida

Ramos

Correia

et al. 2011

Rev. Soc. Bras. Med. Trop.

114

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“…This enables rapid HIV-1 replication and a consequently accelerated progression of HIV/AIDS disease. [3][4][5] Dengue is a tropical and subtropical mosquito-borne disease. According to the World Health Organization 6 , 2.5 billion persons are at risk for contracting dengue infection, resulting in an estimated incidence of 50-100 million cases per year worldwide.…”

Section: Introductionmentioning

confidence: 99%

Dengue Infection in a Human Immunodeficiency Virus-1 Positive Patient Chronically Infected with Hepatitis B Virus in Western Mexico

Delgado‐Enciso

Espinoza‐Gómez

Ochoa-Jiménez

et al. 2017

The American Society of Tropical Medicine and Hygiene

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Abstract. Human immunodeficiency virus (HIV) and dengue coinfection has not been extensively studied. We report herein a case of dengue serotype 1 infection in an HIV-1-positive patient coinfected with hepatitis B virus (HBV) in Colima State, Mexico. CD4 + cells and HIV-1 viremia remained at normal levels, and no severe complications were observed during this multiple viral infection. The alanine transaminase and aspartate transaminase values were elevated before and during dengue infection. Surprisingly, these parameters were significantly reduced 2 months later. Because of the lack of evidence regarding this multiple viral interaction, further research is required to understand the biologic and clinical course of dengue infection in HIV-1/HBV coinfected patients, especially in tropical regions where dengue virus transmission is highly active.

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“…In spite of the considerable increase in knowledge and the use of control measures, acquired immunodeficiency syndrome (AIDS) is still the fifth leading cause of death in the world 14 . In Latin America, Brazil has the highest number of cases despite the use of highly active antiretroviral therapy (HAART), which has been shown to be very effective 16 .…”

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confidence: 99%