Biological screening of Brazilian medicinal plants

Alves, Tânia Maria de Almeida; Silva, Andréia Fonseca; Brandão, Mítzi; Grandi, Telma S. M.; Smânia, Elza de Fátima Albino; Júnior, Artur Smânia; Zani, Carlos L.

doi:10.1590/s0074-02762000000300012

Cited by 324 publications

(214 citation statements)

References 10 publications

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“…Alves et al (2000) showed a discrete antifungal activity against Cladosporium sphaerospermum (a filamentous fungus not tested in our work) for methanol extract of the leaves of L. pacari in agar diffusion assay. The dichloromethane, ethyl acetate and ethanol extracts of the stem bark of Bowdichia virgilioides showed a selective antifungal activity towards hyalohyphomycetes and dermatophytes (MICs = 100-1000 µg/mL), but had no action against yeasts.…”

Section: Seven Medicinal Plants (Bowdichia Virgilioides Calophyllum mentioning

confidence: 70%

“…The other 13 plant extracts showed no antibacterial activity (Table 2), in spite of some works support of antibacterial activity against gram-positive bacteria by leaves (Alves et al, 2000) and leaves and stem bark extracts of L. pacari and B. virgilioides (Alves et al, 2000) as well as bark extract of S. obovatum (Sanches et al, 2005). Such discrepant results may be related with some factors, in particular to environmental factors (seasonality, temperature, collect local, soil nutrients, etc.…”

Section: Seven Medicinal Plants (Bowdichia Virgilioides Calophyllum mentioning

confidence: 94%

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Antimicrobial screening of some medicinal plants from Mato Grosso Cerrado

Silva¹,

Filho²,

Zacchino³

et al. 2009

Rev. bras. farmacogn.

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RESUMO: "Triagem antimicrobiana de algumas plantas medicinais do Cerrado de Mato Grosso". Os extratos em hexano, diclorometano, acetato de etila e etanol das entrecascas de Bowdichia virgilioides, Calophyllum brasiliense, Cariniana rubra, Lafoensia pacari e Stryphnodendron obovatum, do rizoma de Simaba ferruginea e do látex de Croton urucurana foram triados contra um painel de bactérias e fungos usando o método de microdiluição em caldo. O látex de Croton urucurana foi o material derivado de planta com maior atividade antimicrobiana. Os extratos em acetato de etila e hexano da entrecasca de Calophyllum brasiliense destacaram-se por suas seletivas atividades antibacterianas. Os extratos polares da entrecasca de Lafoensia pacari notabilizaram-se por suas potentes e seletivas atividades contra leveduras e os extratos polares e não-polares de Bowdichia virgilioides por suas atividades antifúngicas contra hialo-hifomicetos e dermatófitos. Este é o primeiro relato mostrando atividades antifúngicas para os extratos de Cariniana rubra e Simaba ferruginea. Esse trabalho demonstrou a atividade antimicrobiana de plantas medicinais do Cerrado de Mato Grosso em ensaios in vitro e indica que elas podem ser potenciais candidatas para o desenvolvimento de novas estratégias no tratamento de infecções bacterianas e fúngicas.Unitermos: Plantas medicinais, Cerrado de Mato Grosso, triagem antimicrobiana, ensaio de microdiluição em caldo.ABSTRACT: Hexane, dichloromethane, ethyl acetate and ethanol extracts from stem barks of Bowdichia virgilioides, Calophyllum brasiliense, Cariniana rubra, Lafoensia pacari, and Stryphnodendron obovatum and rhizome of Simaba ferruginea and Dragon's blood red sap from Croton urucurana were screened against a panel of bacteria and fungi using the micro-broth dilution method. Dragon's blood from Croton urucurana was the most effective antimicrobial plant material. Ethyl acetate and hexane extracts of Calophyllum brasiliense stem bark deserved distinction by their selective antibacterial activity. Lafoensia pacari stem bark polar extracts distinguished by their potent and selective anti-yeast activity and Bowdichia virgilioides polar and non-polar extracts by their antifungal activity towards hyalohypho-mycetes and dermatophytes. This is the first report showing antifungal activity for polar extracts of Cariniana rubra and Simaba ferruginea. This study has demonstrated antimicrobial activity of Mato Grosso Cerrado ethnomedicinal plants in in vitro assays and has indicated that they can be effective potential candidates for the development of new strategies to treat fungal and bacterial infections.

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Section: Seven Medicinal Plants (Bowdichia Virgilioides Calophyllum mentioning

confidence: 70%

Section: Seven Medicinal Plants (Bowdichia Virgilioides Calophyllum mentioning

confidence: 94%

Antimicrobial screening of some medicinal plants from Mato Grosso Cerrado

Silva¹,

Filho²,

Zacchino³

et al. 2009

Rev. bras. farmacogn.

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“…In the last years, C. sylvestris has been exploited in the development of creams against herpes and commercialized in mixed formulations with other plants to Duke and Vásquez (1994) prepare teas and infusions with therapeutical purposes (Camargo et al 1993, Alves 2000, Simões et al 1999). An infusion can be easily obtained (20 g of dried leaves per 1 L of water) for oral consumption (2-3 times/day) together with meals, in case of gastric ulcers or for topical treatment of wounds, burns, rashes, eczema and vitiligo (Blanco 2010).…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review

Ferreira

Costa-Lotufo

Moraes

et al. 2011

An. Acad. Bras. Ciênc.

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Folk uses and scientific investigations have highlighted the importance of Casearia sylvestris extracts and their relevant bioactive potential. The aim of this work was to review the pharmacological properties of C. sylvestris, emphasizing its anti-ulcer, anti-inflammatory, anti-ophidian and antitumor potentialities. Ethanolic extracts and essential oil of their leaves have antiulcerogenic activity and reduce gastric volume without altering the stomach pH, which corroborates their consumption on gastrointestinal disorders. Leaf water extracts show phospholipase A 2 inhibitory activity that prevents damage effects on the muscular tissue after toxin inoculation. This antiphospholipasic action is probably related to the use as an anti-inflammatory, proposing a pharmacological blockage similar to that obtained with non-steroidal anti-inflammatory drugs on arachidonic acid and cyclooxygenase pathways. Bioguided-assay fractionations lead to the identification of secondary metabolites, especially the clerodane diterpenes casearins (A-X) and casearvestrins (A-C), compounds with a remarkable cytotoxic and antitumor action. Therefore, the C. sylvestris shrub holds a known worldwide pharmacological arsenal by its extensive folk utilization, exciting searches for new molecules and a better comprehension about biological properties.

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“…The majority of these studies focus on its active principle, normally organic compounds with diverse functions in the body. Given that their consume is increasing, it is interesting to use these plants as a supplement in food taking into account that these plants can present a significant amount of copper, iron, and zinc (ALVES, 2000;CORREA, 1984;TAKASE, 2005a, b).…”

mentioning

confidence: 99%