Immune response in cattle vaccinated against rabies

Oliveira, Alexandre Nunes de; Andrade, Márcia Cristina Ribeiro; Silva, Marlon Vicente da; Moura, Wlamir Corrêa de; Contreiras, Ellen Cortez

doi:10.1590/s0074-02762000000100013

Cited by 25 publications

(26 citation statements)

References 5 publications

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“…These findings prove the need for the application of a booster vaccination for the control of rabies in cattle and confirms the findings of Rodrigues da Silva et al [28], Queiroz da Silva et al [14], Albas et al [15], Giometti et al [16] and Maria et al [29], who showed that reinforcement immunization is required for animals that were previously vaccinated against rabies antibody titers to maintain high and persistent levels of antirabies antibodies.…”

Section: Open Accesssupporting

confidence: 89%

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Effects of primovaccination and booster vaccination on serum cortisol and humoral immune response in cattle

Reis¹,

Pardo²,

Frazatti-Gallina³

et al. 2013

ABB

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The objective of this study was to evaluate the effect of one or two doses of the anti-rabies vaccination on the serum concentration of cortisol and the humoral immune response in cattle as well as the correlation between serum cortisol concentrations and the titers of rabies-neutralizing antibodies. Nelore cattle were randomly assigned to one of three groups, which were vaccinated with one dose of rabies vaccine (group GVSR, N = 15), two doses of rabies vaccine (group GVR, N = 15) or were not vaccinated (group Gc, N = 15). A commercial liquid inactivated rabies vaccine was used. The stressors imposed on the cattle were vaccination, corral handling and the presence of people. Blood samples were collected on days 0, 30 and 60 post-vaccination. Serum cortisol concentrations were determined using a solid-phase radioimmunoassay, and rabies antibody titers were determined using a serum neutralization test with BHK 21 cells (RFFIT). Both serum cortisol concentrations and antibody titers increased after the second (booster) vaccination (P < 0.05). In all the groups, the serum cortisol concentrations increased after the cattle were handled in the corral (P < 0.05). No correlation was observed between the serum cortisol concentrations and the antibody titers with any treatment or on any observation day. In conclusion, booster vaccination is indispensable for primovaccinated cattle in achieving high and protective levels of rabies antibodies. Although booster vaccination and frequent cattle handling in corrals are stressors, the response is not strong enough to cause immunosuppression in cattle.

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Section: Open Accesssupporting

confidence: 89%

“…However, some authors theorize that this value is the minimum required for protection of cattle [16,[27][28][29][30][31]. Thus, as seen in Table 2, 30 days after the first vaccination against rabies, 100% of the animals in the GVSR and GVR group were still susceptible to contracting the rabies virus.…”

Section: Open Accessmentioning

confidence: 99%

Effects of primovaccination and booster vaccination on serum cortisol and humoral immune response in cattle

Reis¹,

Pardo²,

Frazatti-Gallina³

et al. 2013

ABB

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“…By the end of the study, rabies antibody titers had decreased in most of the groups (Figure 2), as expected for primo-vaccinated cattle (30)(31)(32)(33)(34). In contrast, these antibody titers were sustained in group G 3.6 that received selenium supplementation close to 3 mg/day, the dose recommended by the NRC for taurine breeds (23).…”

Section: Introductionsupporting

confidence: 73%

Association between handling stress in the corral and rabies antibody titers in selenium-supplemented cattle

Reis¹,

Chiacchio²,

Oba³

et al. 2009

J. Venom. Anim. Toxins incl. Trop. Dis

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This study determined the correlation between serum cortisol levels and rabies antibody titers in cattle primo-vaccinated against rabies and supplemented with dietary selenium (Se). Sixty Nelore male calves (10 to 12 months old) received daily and individual dietary supplementation with 0, 3.6, 5.4 and 6.4 mg Se (groups Gc, G 3.6 , G 5.4 and G 6.4 , respectively). The animals were vaccinated against rabies (day 0) and subjected to handling stress in the corral for 120 days. Blood sampling procedures were performed on days 0, 15, 30, 60, 90 and 120. Cortisol levels increased until day 90, but had dropped significantly by day 120 (P < 0.01). Rabies antibody titers on days 30 and 90 were similar among Sesupplemented groups; in the control group, rabies antibodies decreased significantly from day 30 to 60, and 90 to 120. Serum cortisol levels and antibody titers were not correlated in most of the groups or blood sampling days. A positive correlation among these variables was found only in G 6.4 on days 60 (R = 0.513; P = 0.05) and 120 (R = 0.644; P = 0.009). In conclusion, repeated handling in the corral stresses cattle, but without compromising rabies humoral immune response.

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“…Similar observations of peak antibody titre during 3-6 weeks post vaccination and waning of antibody titre were made earlier (Aubert, 1992;Oliveira et al, 2000;Manickam et al, 2008;Minke et al, 2009). Although reduction in the antibody response on the day 90 was expected, it's reduction below 0.5 IU in case of 3 animals was unexpected.…”

Section: Resultssupporting

confidence: 83%

Sero monitoring of anti rabies vaccinal antibodies to pep in animals by RFFIT - a case study in Karnataka

KM¹,

Isloor²,

C³

et al. 2016

JEBAS

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KEYWORDS RabiesPost exposure prophylaxis Neutralizing antibodies Animals RFFIT ABSTRACTA dog suspected to be affected with rabies attacked 31 animals in Kesarahatti village of Gangavathi taluk, Koppal District in Karnataka on 14 th June 2015. Of these, 26 animals (14 cattle, 5 buffaloes and 7 dogs) were given the first aid followed by post exposure anti rabies vaccine at 1 (15 th June 2015), 3, 7, 14 and 28 days interval whereas the remaining 5 animals (2 cattle and 3 buffaloes) reportedly died of suspected (based on clinical manifestation) rabies after 8 days of dog bite episode. These 5 animals were not provided first aid and post exposure prophylactic (PEP) vaccination as their exposure to the rabid dog bite went unnoticed. Further, the serum samples could be collected from only 21 out of 26 vaccinated animals on 28 th and 90 th day post vaccination. These serum samples were tested by Rapid Fluorescent Focus Inhibition Test (RFFIT) and the titre of neutralizing antibodies ranged from 1-8 IU/ml from the serum collected on 28 th day post vaccination indicating protection in all the vaccinated animals. But the titre ranged from 0.5-4 IU/ml in 18 animals and less than 0.5 IU/ml in three animals (2 cows and a dog) on 90 th day post vaccination. The protective level of neutralizing antibody titre on day 28 post vaccination and non-development of disease suggests that the PEP vaccination could be effective in livestock avoiding euthanasia and culling of animals.

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Immune response in cattle vaccinated against rabies

Cited by 25 publications

References 5 publications

Effects of primovaccination and booster vaccination on serum cortisol and humoral immune response in cattle

Effects of primovaccination and booster vaccination on serum cortisol and humoral immune response in cattle

Association between handling stress in the corral and rabies antibody titers in selenium-supplemented cattle

Sero monitoring of anti rabies vaccinal antibodies to pep in animals by RFFIT - a case study in Karnataka

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