Effects of primovaccination and booster vaccination on serum cortisol and humoral immune response in cattle

Abstract

The objective of this study was to evaluate the effect of one or two doses of the anti-rabies vaccination on the serum concentration of cortisol and the humoral immune response in cattle as well as the correlation between serum cortisol concentrations and the titers of rabies-neutralizing antibodies. Nelore cattle were randomly assigned to one of three groups, which were vaccinated with one dose of rabies vaccine (group GVSR, N = 15), two doses of rabies vaccine (group GVR, N = 15) or were not vaccinated (group Gc, N = 15). A commercial liquid inactivated rabies vaccine was used. The stressors imposed on the cattle were vaccination, corral handling and the presence of people. Blood samples were collected on days 0, 30 and 60 post-vaccination. Serum cortisol concentrations were determined using a solid-phase radioimmunoassay, and rabies antibody titers were determined using a serum neutralization test with BHK 21 cells (RFFIT). Both serum cortisol concentrations and antibody titers increased after the second (booster) vaccination (P < 0.05). In all the groups, the serum cortisol concentrations increased after the cattle were handled in the corral (P < 0.05). No correlation was observed between the serum cortisol concentrations and the antibody titers with any treatment or on any observation day. In conclusion, booster vaccination is indispensable for primovaccinated cattle in achieving high and protective levels of rabies antibodies. Although booster vaccination and frequent cattle handling in corrals are stressors, the response is not strong enough to cause immunosuppression in cattle.

Changes in serum antibody titer following rabies vaccination in the giant panda

“…As these pandas grow older their immune systems will begin to mature as well. A similar phenomenon was observed in cattle by Reis et al (2009Reis et al ( & 2013. These results suggest that an optimized vaccination plan be formulated or administer panda cubs with a booster dose of vaccine.…”

Two Hours of Separation Prior to Milking: Is This Strategy Stressful for Jennies and Their Foals?

“…Behavioural responses facilitate physiological adaptations, which may manifest via the activation of the autonomous nervous system and neuroendocrine system [ 39 ]. The stimulation of central circuits involving the amygdala, hypothalamus and periaqueductal gray (PAC) result in an increased frequency of eliminative behaviour [ 40 ], and increased releases of corticotropin-releasing factor (CRF), from the hypothalamus, and adrenocorticotropic hormone (ACTH), from the pituitary gland culminate in an increase in the secretion of glucocorticoids, such as cortisol [ 41 ], from the adrenal glands. Alveolar milk ejection could also be altered by fear or stress, due to the influence of these endocrine factors on oxytocin concentration and myoepithelial contraction [ 42 , 43 ].…”

Efeito Da Avaliação Da Vacinação Antirrábica E Suplementação Com Diferentes Doses Do Probiótico Na Resposta Imune Humoral Em Bezerros Nelore

“…causada por um vírus neurotrópico, RNA, de ordem Mononegavirales, família Rhabdoviridae e do gênero Lyssavirus (REIS et al, 2013), onde no Brasil, o principal agente transmissor do vírus rábico é o morcego hematófago Desmodus rotundus (ALBAS et al, 2006;SCHEFFER et al, 2007).…”

“…A vacinação de bovinos contínua e periódica é a melhor forma de proteger e controlar a doença, porque a vacinação é de baixo custo eficaz e reduz perdas econômicas (REIS et al, 2013).…”