Elimination of the vectorial transmission of Chagas disease in Central American countries: Honduras

Ponce, Carlos

doi:10.1590/s0074-02761999000700082

Cited by 17 publications

(14 citation statements)

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“…Most countries in Central America have relatively small territorial extensions and a high prevalence of T. cruzi-infected individuals (7,10,13). In general, laboratories for the diagnosis of infectious diseases are small, have few resources, and perform a limited number of tests per day.…”

Section: Discussionmentioning

confidence: 99%

“…T. cruzi is naturally transmitted to mammalian hosts through the urine and feces of infected hematophagous bugs or by blood transfusion or the ingestion of contaminated food; it may also be transmitted congenitally or through organ transplantation (10,13). In Honduras, 20% of chronic cardiopathies are from chagasic patients, and 36% of pacemakers implanted in Guatemala and Honduras are for arrhythmias due to chagasic cardiopathy (7).…”

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confidence: 99%

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Validation of a Rapid and Reliable Test for Diagnosis of Chagas' Disease by Detection of Trypanosoma cruzi -Specific Antibodies in Blood of Donors and Patients in Central America

Ponce

Vinelli

et al. 2005

J Clin Microbiol

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In this study we compared the performance of the Chagas Stat-Pak rapid immunochromatographic test with a standard enzyme-linked immunosorbent assay (ELISA) in the serodiagnosis of Chagas' disease in Central America. Out of 3,400 blood donor samples, 156 (4.6%) were positive in both assays. Three sera out of 2,084 samples from reference laboratories were negative with the rapid test but positive with the ELISA (99.8% agreement). Agreement of 100% between the two tests was observed with 339 additional sera from patients with cardiopathies and 175 sera from potential blood donors in emergency surgical cases occurring on weekends or at night. In conclusion, Chagas Stat-Pak showed 99.6% and 99.9% sensitivity and specificity, respectively, when assayed with 5,998 serum samples. It is a sensitive and specific alternative to the ELISA, as required in medical emergencies and blood screenings in Central America.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Validation of a Rapid and Reliable Test for Diagnosis of Chagas' Disease by Detection of Trypanosoma cruzi -Specific Antibodies in Blood of Donors and Patients in Central America

Ponce

Vinelli

et al. 2005

J Clin Microbiol

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“…While the domestic species R. prolixus has been reported to support higher transmission rates to humans and is therefore considered to be a more important disease vector (Ponce, 1999;Tabaru et al, 1999), T. dimidiata is a much greater challenge to control because of its adaptation to both domestic and peri-domestic habitats. Vector control programs in South America have proven highly successful at reducing both home infestation rates and the incidence of new infections in affected areas (Schmunis et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of microsatellite markers in the Chagas disease vector Triatoma dimidiata

Anderson¹,

Lai²,

Dotson³

et al. 2002

Infection, Genetics and Evolution

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“…Our results from previous studies conducted during [1997][1998][1999][2000] Central America (Schofield & Dujardin 1997, Dujardin et al 1998, Ponce 1999. On the other hand Triatoma dimidiata, distributed in the wild in the coastal areas of Chiapas could not be considered as a candidate for eradication (Dias & Schofield 1999, Acevedo et al 2000.…”

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confidence: 55%

“…Considering the success of the Southern Cone initiative, and the Andean initiative in 1997 as a reference, the success of the Central American initiative for the control of Chagas disease vectors (Moncayo 1999, Ponce 1999 was promising.…”

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confidence: 99%

Activity and Residual Effect of Two Formulations of Lambdacyhalothrin Sprayed on Palm Leaves to Rhodnius prolixus

Mazariego-Arana

Juan

Alejandre‐Aguilar

et al. 2002

Mem. Inst. Oswaldo Cruz

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The insecticidal activity and residual effect of two formulations of lambdacyhalothrin were evaluated withAmerican trypanosomiasis is a zoonosis of great importance in Latin American countries and is produced by the hemoflagellate parasite Trypanosoma cruzi. This protozoan lives and proliferates in the gut of blood-sucking Reduviidae insects and can be transmitted to humans, producing heart and intestinal lesions described as Chagas disease (Ferro et al. 1995). Transmission by insect vectors represents 80% of all the cases of this illness (Dias & Schofield 1999).The "domestic" species of triatomines, the most important vectors of Chagas disease, are very sensitive to control sprayings with modern insecticides and changes to hygienic house conditions. In this case the determination of the basic susceptibility of the target vector, as well as the residual effect of the product (OPS 1984) is of major importance.Considering the success of the Southern Cone initiative, and the Andean initiative in 1997 as a reference, the success of the Central American initiative for the control of Chagas disease vectors (Moncayo 1999, Ponce 1999) was promising.Our results from previous studies conducted during [1997][1998][1999][2000] Central America (Schofield & Dujardin 1997, Dujardin et al. 1998, Ponce 1999. On the other hand Triatoma dimidiata, distributed in the wild in the coastal areas of Chiapas could not be considered as a candidate for eradication (Dias & Schofield 1999, Acevedo et al. 2000.The purpose of this paper, was to carry out a biossay to determine mortality of laboratory grown R. prolixus fifth-instar nymphs when exposed to contact with three doses of two formulations (WP and SC) of lambdacyhalothrin under laboratory conditions and to determine the residual effect on R. prolixus applying the insecticide on palm leaves roofs in field conditions. R. prolixus is considered the most important triatomine species in the state of Chiapas, Mexico. MATERIALS AND METHODSTriatomines -The tests were performed on fifth-instar nymphs of R. prolixus bugs obtained from a colony maintained in our laboratory at 29 ± 1°C, 87 ± 3% RH, and fed on rabbits once per week (Ryckman 1951). These bugs come from insects captured inside houses in Palenque, northern Chiapas.Susceptibility to insecticide -Ten fifth-instar nymphs were placed on palm leaves previously sprayed with lambdacyhalothrin (Commodore® WP 10 and Demand® SC 2.5) by 60 min and observing the percent of mortality after 24 h (Mazariego-Arana 1997). Palm leaves were treated with two surfaces each time for different dose and each of these tests were repeated at least three times. In the control group were used palm leaves not treated previously. The percentage of mortality obtained with each dose were plotted in a log-probit scale with the help of a computer program (Raymond 1996). The LC 50 and LC 90 were then obtained, together with the 95% upper and lower confidence limits.Trial site -Field tests were conducted in the two neighboring communities (Arimatea and Nueva Galilea) ...

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Elimination of the vectorial transmission of Chagas disease in Central American countries: Honduras

Cited by 17 publications

References 1 publication

Validation of a Rapid and Reliable Test for Diagnosis of Chagas' Disease by Detection of Trypanosoma cruzi -Specific Antibodies in Blood of Donors and Patients in Central America

Validation of a Rapid and Reliable Test for Diagnosis of Chagas' Disease by Detection of Trypanosoma cruzi -Specific Antibodies in Blood of Donors and Patients in Central America

Identification and characterization of microsatellite markers in the Chagas disease vector Triatoma dimidiata

Activity and Residual Effect of Two Formulations of Lambdacyhalothrin Sprayed on Palm Leaves to Rhodnius prolixus

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