Wild Rodents as Experimental Intermediate Hosts of Lagochilascaris minor Leiper, 1909

Paçô, Julieta Machado; Campos, Dulcinéa Maria Barbosa; Oliveira, Jayrson Araújo de

doi:10.1590/s0074-02761999000400003

Cited by 38 publications

(37 citation statements)

References 12 publications

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“…A heteroxene cycle has been proposed after various studies with experimental models with rodents as intermediary hosts, since the parasite's development stops at the third stage larvae (L3) and turns into a cyst form. In felines (definitive hosts), L. minor reaches the adult stage with the presence of all life stages in the associated lesions 2,7,11 . Under these conditions, L. minor infections are acquired by the ingestion of encysted L3 found in the intermediary hosts (rodents), from raw or uncooked meat 7 .…”

Section: Introductionmentioning

confidence: 99%

Lagochilascaris minor Leiper, 1909 (Nematoda: Ascarididae) in Mexico: three clinical cases from the Peninsula of Yucatan

Barrera-Pérez

Manrique-Saide

Reyes‐Novelo

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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SUMMARYHuman lagochilascariasis (HL) is a parasite produced by Lagochilascaris minor Leiper 1909 that also can be found in cats and dogs. HL is considered an emerging zoonosis in the Americas, spreading from Mexico to Argentina, and the Caribbean Islands. The present paper describes three HL cases from the Peninsula of Yucatan, Mexico, recorded in the last decade. It describes the characteristics of the lesions and discusses the route of transmission in humans and particularly in the observed patients.

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Section: Introductionmentioning

confidence: 99%

Lagochilascaris minor Leiper, 1909 (Nematoda: Ascarididae) in Mexico: three clinical cases from the Peninsula of Yucatan

Barrera-Pérez

Manrique-Saide

Reyes‐Novelo

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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“…6 Wild rodents like guinea pigs, agouti, and capybara become infected by consuming eggs of Lagochilascaris that are expelled with feces by infected wild felines; the rodents then become intermediate hosts. 8 Lagochilascariasis is mostly seen in humans living in or close to forested areas and who maintain a diet of hunted meat, including the species previously mentioned. 4 Humans can be considered as accidental hosts who become infected by ingesting raw or undercooked meat of the intermediate host that contains encysted larvae.…”

Section: Discussionmentioning

confidence: 99%

A Case of Lagochilascariasis in Suriname with the Involvement of the ENT System and the Skull Base

Douma

Akrum

Joe

et al. 2016

The American Journal of Tropical Medicine and Hygiene

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Abstract. We describe a case of human lagochilascariasis, with skull-base involvement and a chronic and relapsing course after treatment. This rare parasitic infection is usually manifested in the head and neck area, characterized by progressive granulomatous inflammation and the formation of abscesses. Transmission to humans most likely occurs by the consumption of undercooked meat of wild rodents. On the basis of literature studies, we propose the most likely life cycle of the parasite that involves wild feline and rodent species, with humans as accidental hosts. Even in endemic areas, it is very difficult to recognize the disease at an early stage. Progression will eventually lead to involvement of the (central) nervous system, as described in our case. Treatment is often difficult and involves resection and prolonged treatment with anthelmintic drugs. Recurrences are not uncommon and at present, long-term oral administration of ivermectin seems to be the most effective treatment.

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“…Infection with Lagochilascaris minor occurs mainly after the ingestion of third stage larvae encysted in different tissues of wild animals 5,14,22 . The larvae get rid of the cysts in the host stomach, cross the digestive wall, and by an unknown tropism mechanism, migrate to the commonly affected regions of head, neck, and thorax 5,18,22 .…”

Section: Discussionmentioning

confidence: 99%

“…Most of the cases occurred in tropical regions of Central and South America. Brazil is the leading country in the world, accounting for 75% of reported cases in humans, mainly in the Amazon region 6,14,21 , but there are cases in other parts of the country 6,9,14,16,20 . Cases have been reported in Venezuela 13,23 14 .…”

Section: Introductionmentioning

confidence: 99%

Lagochilascariasis leading to severe involvement of ocular globes, ears and meninges

Aquino¹,

Magliari²,

Filho³

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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SUMMARYA case report of a 31 year-old woman from Paraíba State (North-Eastern Brazil) that presented severe involvement of ocular globes, ears and meninges. Diagnosis was established after enucleation of her left eye, when adult worms were seen in the midst of a granulomatous inflammatory process. Her response to the initial treatment with levamisole and cambendazole was good, but there was a relapse after the fifth month of treatment even with maintenance doses of both medications. She later received ivermectin and albendazol and responded well.

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Wild Rodents as Experimental Intermediate Hosts of Lagochilascaris minor Leiper, 1909

Cited by 38 publications

References 12 publications

Lagochilascaris minor Leiper, 1909 (Nematoda: Ascarididae) in Mexico: three clinical cases from the Peninsula of Yucatan

Lagochilascaris minor Leiper, 1909 (Nematoda: Ascarididae) in Mexico: three clinical cases from the Peninsula of Yucatan

A Case of Lagochilascariasis in Suriname with the Involvement of the ENT System and the Skull Base

Lagochilascariasis leading to severe involvement of ocular globes, ears and meninges

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