The life cycle of Lagochilascaris minor was studied using material collected from human lesion and applying the experimental model: rodents (mice, hamsters), and carnivorae (cats, dogs). In mice given infective eggs, orally, hatch of the third stage larvae was noted in the gut wall, with migration to liver, lungs, skeletal musculature and subcutaneous tissue becoming, soon after, encysted. In cats infected with skinned carcasses of mice (60 to 235 days of infection) it was observed: hatch of third stage larvae from the nodules (cysts) in the stomach, migration through the oesophagus, pharynx, trachea, related tissues (rhino-oropharynx), and cervical lymphonodes developing to the mature stage in any of these sites on days 9-20 post inoculation (P.I.). There was no parasite development up to the mature stage in cats inoculated orally with infective eggs, which indicates that the life cycle of this parasite includes an obligatory intermediate host. In one of the cats (fed carcass of infected mice) necropsied on day 43 P.I., it was observed the occurence of the self-infective cycle of L. minor in the lung tissues and in the cervical region which was characterized by the finding of eggs in different stages of development, third stage larvae and mature worms. It's believed that some component of the carnivorae gastrointestinal tracts may preclude the development of third stage larvae from L. minor eggs what explains the interruption of the life cycle in animals fed infective eggs. It's also pointed out the role of the intermediate host in the first stages of the life cycle of this helminth.
SUMMARYThe authors report on a new case of human Bertiellosis in a 2-year old female patient who was born in Goiânia-Goiás (Brazil) and has had history of permanent dwelling in an area frequently visited by simians in Mato Grosso (Brazil). At the time of diagnosis the patient showed inappetence, abdominal pain, and loss of weight. Eggs and proglottids were found in her stool and were identified as Bertiella sp. The objective of this report is to register the third case of human Bertiellosis in Brazil, characterizing one more case of helminthic zoonosis.
A lagochilascariose é uma infecção causada por vermes do género Lagochilascaris. A doença humana é restrita ao continente americano e tem sido associada a Lagochilascaris minor. É considerada uma helmintíase emergente e o Brasil lidera a casuística mundial com aproximadamente 90% dos casos descritos na literatura mundial. Esta revisão tem como objetivo divulgar informações sobre a lagochilascariose desde a época em que foi descrita até os dias atuais.UNITERMOS: Lagochilascaris minor. Lagochilascariose. Helmintíase emergente. INTRODUÇÃOEmbora Lagochilascaris minor tenha sido descrito, desde 1909, em material procedente de lesão humana, até hoje não se conhecem os hospedeiros naturais deste helminto. Esta espécie tem sido encontrada determinando lesões tumorais geralmente fistulizada no homem e, eventualmente, em cães e gatos domésticos. As lesões humanas localizam-se na região cervical e tecidos relacionados, como mastóide, maxila, tonsila, globo ocular, pescoço, seios nasais, ouvido, sistema nervoso central, pulmão, rinofaringe, alvéolo dentário, além da região sacra. A infecção humana pode ter evolução crónica, de 5 a 20 anos de duração, ou levar o indivíduo ao óbito três meses após o início dos sintomas.A distribuição geográfica da lagochilascariose humana é restrita a países da região neotropical como México,
desde 1989, utilizando-se o modelo experimental: camundongo e gato dom6stico. No inicio destes estudos, ovos infectantes do parasito eram obtidos por dissecapSo de alcas uterinas de femeas de L. minor recuperadas de lesOes cervicais humanas. Posteriormente, observou-se que em gates infectados experimentalmente os parasites localizam-se, preferencialmente, em tecidos da rino e orofaringe. Nestes tecidos, vermes s3o encontrados no interior de tumoracOes que se fistulam para a luz do tubo digestive liberando grande quantidade de ovos nas fezes destes animais. Visando otimizar a obtencao de ovos eliminados pelas femeas de L. minor, propos-se o emprego do metodo de sedimentafSo espontanea acrescido do metodo de centrifugo-flutuacao em sulfato de zinco (Faust e cols.) em fezes de gates infectados. A utilizafao destes metodos permitiu obter ovos larvados, viaveis, livres de detritos fecais e em maior proporcao do que por dissecapao de al9as uterinas do verme. DESCRITORES: Isolado de Lagochilascaris minor. Ovos infectantes. INTRODUQAOA lagochilascariase, infec?ao provocada pelo ascarideo Lagochilascaris minor, e considerada uma doen9a emergente e restrita ao continente americano. O Brasil lidera a casuistica mundial, sendo a maioria
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