Comparison between Human Immunodeficiency Virus Positive and Negative Patients with Tuberculosis in Southern Brazil

Henn, Lucelia A.; Nagel, Fabiano Marcio; Dal‐Pizzol, Felipe

doi:10.1590/s0074-02761999000300017

Cited by 27 publications

(19 citation statements)

References 14 publications

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“…In the present study, 73.6% of the patients were nonwhite. This finding differs from what has been found in other regions of Brazil 11 , where there is a preponderance of Caucasians among the patients with associated tuberculosis/HIV. Regarding education levels, our findings are comparable with the data from another Brazilian study 10 , in which the majority of the patients studied until the end of elementary school and a smaller proportion studied in high school or higher.…”

Section: Discussioncontrasting

confidence: 99%

Clinical and radiographic features of HIV-related pulmonary tuberculosis according to the level of immunosuppression

Garcia

Moura

Ferreira

et al. 2007

Rev. Soc. Bras. Med. Trop.

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Medical charts and radiographs from 38 HIV-infected patients with positive cultures for Mycobacterium tuberculosis from sputum or bronchoalveolar lavage were reviewed in order to compare the clinical, radiographic, and sputum bacilloscopy characteristics of HIV-infected patients with pulmonary tuberculosis according to CD4+ lymphocyte count (CD4). The mean age of the patients was 32 years and 76% were male. The median CD4 was 106 cells/mm³ and 71% had CD4 < 200 cells/mm³. Sputum bacilloscopy was positive in 45% of the patients. Patients with CD4 < 200 cells/mm³ showed significantly less post-primary pattern (7% vs. 63%; p = 0.02) and more frequently reported weight loss (p = 0.04). Although not statistically significant, patients with lower CD4 showed lower positivity of sputum bacilloscopy (37% vs. 64%; p = 0.18). HIV-infected patients with culture-confirmed pulmonary tuberculosis had a high proportion of non-post-primary pattern in thoracic radiographs. Patients with CD4 lower than 200 cells/mm³ showed post-primary patterns less frequently and reported weight loss more frequently.

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Section: Discussioncontrasting

confidence: 99%

Clinical and radiographic features of HIV-related pulmonary tuberculosis according to the level of immunosuppression

Garcia

Moura

Ferreira

et al. 2007

Rev. Soc. Bras. Med. Trop.

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“…In the HIV-negative group, chest (12,13) reported a higher prevalence of fever and fatigue among HIV-positive patients, a result that is in disagreement with those of the present study. However, those studies were based on data collected from medical records rather than on those obtained by focused history taking, which might explain the difference.…”

Section: Resultscontrasting

confidence: 99%

“…Various authors have reported that mediastinal lymph node enlargement is a common radiological finding in immunocompromised patients with tuberculosis. (12,25) In the present study, mediastinal lymph node enlargement was found in 5% of the X-rays of HIV-positive individuals and in none of those of HIV-negative individuals (p = 0.465), similar to the findings of another study. (15) In the evaluation of the degree of immunosuppression, intrathoracic lymph node enlargement is the radiological finding that is related to the lowest CD4 + T-cell counts.…”

Section: Discussionsupporting

confidence: 91%

“…In studies analyzing the degree of immunosuppression in individuals with tuberculosis/HIV co-infection, cavitation was reported to be most common in those with a CD4 + T-cell count > 200 cells/mm 3 . (12,25) Another different finding of the present study was a higher prevalence of interstitial lesions among the patients in the HIV-negative group (p = 0.012). One group of authors (26) found that, among patients with tuberculosis/ HIV co-infection, interstitial lesions were most common in those with a CD4 + T-cell count < 200 cells/mm 3 .…”

Section: Discussioncontrasting

confidence: 77%

See 1 more Smart Citation

Manifestações clínicas, radiológicas e laboratoriais em indivíduos com tuberculose pulmonar: estudo comparativo entre indivíduos HIV positivos e HIV negativos internados em um hospital de referência

2011

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Objective: To compare clinical, radiological, and laboratory characteristics of individuals with pulmonary tuberculosis co-infected or not with HIV. Methods: A cross-sectional study, in which signs and symptoms were assessed by anamnesis and physical examination in patients hospitalized with pulmonary tuberculosis. The results of sputum smear microscopy and culture for Mycobacterium tuberculosis, as well as hemoglobin levels and CD4 + T-cell counts, were obtained from medical records, and chest X-ray reports were consulted. Results: We included 50 pulmonary tuberculosis patients, who were divided into two groups (HIV-positive and HIV-negative; n = 25 per group). The mean age of the participants was 38.4 ± 10.5 years; 46 (92%) were males; and 27 (54%) were White. Expectoration was presented by 21 (84%) and 13 (52%) of the patients in the HIV-negative and HIV-positive groups, respectively (p = 0.016). Radiological findings of cavitation were present in 10 (43%) and 2 (10%) of the patients in the HIV-negative and HIV-positive groups, respectively (p = 0.016), whereas an interstitial pattern was observed in 18 (78%) and 8 (40%), respectively (p = 0.012). The mean hemoglobin level was 11.1 ± 2.9 g/ dL and 9.3 ± 2.2 g/dL in the HIV-negative and HIV-positive groups, respectively (p = 0.015). Conclusions: In our sample of tuberculosis patients, expectoration was less prevalent, hemoglobin levels were lower, and cavitation was less common, as was an interstitial pattern, among those co-infected with HIV than among those without HIV co-infection.Keywords: HIV; Tuberculosis; Acquired immunodeficiency syndrome. ResumoObjetivo: Comparar as manifestações clínicas, radiológicas e laboratoriais de indivíduos com tuberculose pulmonar coinfectados com HIV com aqueles sem a coinfecção. Métodos: Estudo transversal, no qual sinais e sintomas foram analisados por meio de anamnese e exame físico em pacientes internados com tuberculose pulmonar. A baciloscopia, a cultura para Mycobacterium tuberculosis, a dosagem de hemoglobina e a contagem de células T CD4 + foram obtidas de registros dos prontuários, assim como os laudos das radiografias de tórax. Resultados: Foram incluídos 50 pacientes com tuberculose pulmonar, que foram divididos em dois grupos (HIV positivo e HIV negativo; n = 25 por grupo). A média de idade dos participantes foi de 38,4 ± 10,5 anos, 46 (92%) eram do sexo masculino, e 27 (54%) eram caucasianos. Apresentaram expectoração 21 (84%) e 13 (52%) dos pacientes nos grupos HIV negativo e HIV positivo, respectivamente (p = 0,016). Achados radiológicos de cavitação estavam presentes em 10 (43%) e 2 (10%) dos pacientes nos grupos HIV negativo e HIV positivo, respectivamente (p = 0,016), ao passo que padrão intersticial estava presente em 18 (78%) e 8 (40%) dos pacientes nesses grupos (p = 0,012). O nível médio de hemoglobina foi de 11,1 ± 2,9 g/dL e 9,3 ± 2,2 g/dL nos grupos HIV negativo e HIV positivo, respectivamente (p = 0,015). Conclusões: Entre pacientes coinfectados com tuberculose e HIV desta amostra, houve me...

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“…Kerr-Pontes et al [21] and Henn [22] also reported that (male) gender is a high risk factor for developing active TB. In addition, there are more men with registered cases of TB without HIV, at a ratio of 2:1 men to women [23].…”

Section: Discussionmentioning

confidence: 96%

Factors related to HIV/tuberculosis coinfection in a Brazilian reference hospital

Carvalho¹,

Monteiro²,

Neto³

et al. 2008

Braz J Infect Dis

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Infection with both Human Immunodeficiency Virus (HIV) and Mycobacterium tuberculosis is currently the world's leading cause of death due to infectious agents. We evaluated factors related to the development of tuberculosis (TB) in HIV-infected patients who were being treated at an infectious diseases hospital in Fortaleza, Ceará, Brazil. From January 2004 to December 2005, we made an epidemiological study through the analysis of the medical records of 171 patients, who were diagnosed as having both HIV and tuberculosis. Among these co-infected patients, most (81%, p=0.0006) were male. Co-infection was more frequent (87.8%) among patients over 40 years of age and those with lower educational levels (less than eight years of schooling). Forty-one percent of the patients in the study had not had a smear culture test for acid-fast bacilli (AFB). CD4 cell counts were lower than 200 cells/µ µ µ µ µL in 71.9% of the patients, the mean being 169 cells/µ µ µ µ µL. This type of data is important for establishing strategies to improve the control of tuberculosis in HIV-infected patients.

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Comparison between Human Immunodeficiency Virus Positive and Negative Patients with Tuberculosis in Southern Brazil

Cited by 27 publications

References 14 publications

Clinical and radiographic features of HIV-related pulmonary tuberculosis according to the level of immunosuppression

Clinical and radiographic features of HIV-related pulmonary tuberculosis according to the level of immunosuppression

Manifestações clínicas, radiológicas e laboratoriais em indivíduos com tuberculose pulmonar: estudo comparativo entre indivíduos HIV positivos e HIV negativos internados em um hospital de referência

Factors related to HIV/tuberculosis coinfection in a Brazilian reference hospital

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