Effects of Schistosomal mansoni infection on Calomys callosus coelom-associated lymphomyeloid tissue (milky spots)

Lenzi, J. A.; Pelajo-Machado, Marcelo; Mota, Eduardo; Oliveira, Denise N.; Panasco, Mônica S; Andrade, Zilton de Araújo; Lenzi, Henrique Leonel

doi:10.1590/s0074-02761998000700003

Cited by 4 publications

(4 citation statements)

References 33 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In conclusion, the results showed that N. squamipes, natural and experimentally infected with S. mansoni, reproduced, with small variations, the hepatic granuloma aspects already described in cricetidium (C. callosus) (Lenzi et al 1995, Lenzi 1998b, showing a genetic tendency to set up strong macrophage responses and small granulomas. Unexpectedly, natural infection did not engender distinguished histopathological characteristics distinct from those derived from experimental single infection, showing changes predominantly secondary to the duration of infection.…”

Section: Discussionsupporting

confidence: 55%

“…Capron et al (1965) proposed a causal relationship between pigment deposits and fibrogenesis in liver. However, Andrade and Andrade (1965), Stenger et al (1967), Grimaud et al (1976) and Lenzi et al (1995Lenzi et al ( , 1998b granuloma development and regulation were not well explored in the S. mansoni pathogenesis, since Hz has been involved in many biological activities such as impairment of phagocytic function , induction of lipoperoxidation , Arese & Schwarzer 1997 and hydroxyeicosatetraenoic acids (HETEs) production (Green et al 1996), immunomodulations of macrophages affecting antigen processing, chemokine and cytokine secretion (Pichyangkul et al1994, Green et al 1996, Schwarzer et al 1998, Scorza et al 1999.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice

Costa-Silva

Rodrigues-Silva²,

Hulstijn

et al. 2002

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice

Costa-Silva

Rodrigues-Silva²,

Hulstijn

et al. 2002

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

show abstract

“…If not, each coelomic cavity would maintain its primordial immune system independently. CALT, which is made up of MS, is likely to be ontogenetically derived from splanchnopleura [intraembryonic aorta (dorsal), genital ridge and mesonephros] (Dzierzak & Medvinsky 1995) and represents a primordial organ that maintains the "phylogenetic memory" of the coelomassociated lymphomyeloid organs (Lenzi et al 1998).…”

mentioning

confidence: 99%

Omental and pleural milky spots: different reactivity patterns in mice infected with Schistosoma mansoni reveals coelomic compartmentalisation

Panasco

Pelajo-Machado

Lenzi

2010

Mem. Inst. Oswaldo Cruz

Self Cite

View full text Add to dashboard Cite

In vertebrate animals, pleural and peritoneal cavities are repositories of milky spots (MS), which constitute an organised coelom-associated lymphomyeloid tissue that is intensively activated by Schistosoma mansoni infection. This study compared the reactive patterns of peritoneal MS to pleural MS and concluded from histological analysis that they represent independent responsive compartments. Whole omentum, lungs and the entire mediastinum of 54 S. mansoni-infected mice were studied morphologically. The omental MS of infected animals were highly activated, modulating from myeloid-lymphocytic (60 days of infection) to lymphomyeloid (90 days of infection) and lymphocytic or lymphoplasmacytic (160 days of infection) types. The non-lymphoid component predominated in the acute phase of infection and was expressed by monocytopoietic, eosinopoietic and neutropoietic foci, with isolated megakaryocytes and small foci of late normoblasts and mast cells. Nevertheless, pleural or thoracic MS of infected mice were monotonous, consisting of small and medium lymphocytes with few mast and plasma cells and no myeloid component. Our data indicate that compartmentalisation of the MS response is dependent on the lymphatic vascularisation of each coelomic cavity, limiting the effects or consequences of any stimulating or aggressive agents, as is the case with S. mansoni infection

show abstract

“…During schistosomiasis, C. callosus present an omental reactivity in milky spots with patches that represent subsidiary foci of lymphomyeloid tissue-associated coelom (CALT), which was also observed in mice [ 95 , 96 ]. S. mansoni worms live predominantly in mesenteric vessels, and consequently, their released products can reach the mesenteric and omental microcirculation, which leads to CALT [ 97 ].…”

Section: Schistosomiasismentioning

confidence: 99%

Calomys callosus: An Experimental Animal Model Applied to Parasitic Diseases Investigations of Public Health Concern

et al. 2022

View full text Add to dashboard Cite

The appearance and spread of parasitic diseases around the world aroused the interest of the scientific community to discover new animal models for improving the quality and specificity of surveys. Calomys callosus is a rodent native to South America, an easy handling model, with satisfactory longevity and reproducibility. C. callosus is susceptible to toxoplasmosis and can be used as experimental model for the study the pathogenesis, treatment, vertical transmission, and ocular toxoplasmosis. C. callosus can also be used to study cutaneous and visceral leishmaniasis, as the animals present cutaneous lesions, as well as parasites in the organs. C. callosus has epidemiological importance in Chagas disease, and since it is a Trypanosoma cruzi natural host in which rodents show high parasitemia and lethality, they are also effective as a model of congenital transmission. In the study of schistosomiasis, Schistosoma mansoni was proven to be a C. callosus natural host; thus, this rodent is a great model for fibrosis, hepatic granulomatous reaction, and celloma associated with lymphomyeloid tissue (CALT) during S. mansoni infection. In this review, we summarize the leading studies of parasitic diseases that used C. callosus as a rodent experimental model, describing the main uses and characteristics that led them to be considered an effective model.

show abstract

Effects of Schistosomal mansoni infection on Calomys callosus coelom-associated lymphomyeloid tissue (milky spots)

Cited by 4 publications

References 33 publications

Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice

Natural Schistosoma mansoni infection in Nectomys squamipes: histopathological and morphometric analysis in comparison to experimentally infected N. squamipes and C3H/He mice

Omental and pleural milky spots: different reactivity patterns in mice infected with Schistosoma mansoni reveals coelomic compartmentalisation

Calomys callosus: An Experimental Animal Model Applied to Parasitic Diseases Investigations of Public Health Concern

Contact Info

Product

Resources

About