Evolutionary Control of Infectious Disease: Prospects for Vectorborne and Waterborne Pathogens

Ewald, Paul W.; Sussman, Jeremy B.; Distler, Matthew T.; Libel, Camila; Chammas, Wahid P.; DiRita, Victor J.; Salles, C. A.; Vicente, Ana Carolina Paulo; Heitmann, Ingrid; Cabello, Felipe C.

doi:10.1590/s0074-02761998000500002

Cited by 17 publications

(17 citation statements)

References 24 publications

(23 reference statements)

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“…The carriage of the cag PAI and of putatively toxigenic s1 alleles of vacA, which contribute to virulence when active, is in accord with the high abundance (about 90%) of this strain type in mainstream Indian populations (8,28), the high overall risk of H. pylori infection in these populations, and the idea that frequent transmission tends to select for more virulent strains of a pathogen (15). This abundance is also remarkable, in light of the apparent absence of H. pylori-associated gastrointestinal disease in these populations.…”

Section: Discussionmentioning

confidence: 72%

Virulence Genes and Neutral DNA Markers ofHelicobacter pyloriIsolates from Different Ethnic Communities of West Bengal, India

et al. 2003

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Virulence-associated genes and neutral DNA markers of Helicobacter pylori strains from the Santhal and Oroan ethnic minorities of West Bengal, India, were studied. These people have traditionally been quite separate from other Indians and differ culturally, genetically, and linguistically from mainstream Bengalis, whose H. pylori strains have been characterized previously. H. pylori was found in each of 49 study participants, although none had peptic ulcer disease, and was cultured from 31 of them. All strains carried the cag pathogenicity island and potentially toxigenic s1 alleles of vacuolating cytotoxin gene (vacA) and were resistant to at least 8 g of metronidazole per ml. DNA sequence motifs in vacA mid-region m1 alleles, cagA, and an informative insertion or deletion motif next to cagA from these strains were similar to those of strains from ethnic Bengalis. Three mobile elements, IS605, IS607, and ISHp608, were present in 29, 19, and 10%, respectively, of Santhal and Oroan strains, which is similar to their prevalence in Bengali H. pylori. Thus, there is no evidence that the gene pools of H. pylori of these ethnic minorities differ from those of Bengalis from the same region. This relatedness of strains from persons of different ethnicities bears on our understanding of H. pylori transmission between communities and genome evolution.

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Section: Discussionmentioning

confidence: 72%

Virulence Genes and Neutral DNA Markers ofHelicobacter pyloriIsolates from Different Ethnic Communities of West Bengal, India

et al. 2003

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“…With the recognition of the importance of understanding parasite evolution in the control of modern diseases (Ewald 1996, Ewald et al 1998, paleoparasitology has a new importance. The understanding of parasite evolution can be addressed by the combined approaches of paleoparasitology and molecular paleoparasitology.…”

Section: Parasite Evolution and Paleoparasitologymentioning

confidence: 99%

Parasitism, the diversity of life, and paleoparasitology

Araújo

Jansen

Bouchet

et al. 2003

Mem. Inst. Oswaldo Cruz

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“…It is generally impossible to eliminate pathogens (Ewald et al 1998). Researchers should understand the role of pathogens in sustaining and evolving in the context of the human ecosystem.…”

Section: Improved Disease Controlmentioning

confidence: 99%

Environment–KHV–carp–human linkage as a model for environmental diseases

Kawabata

Minamoto

Honjo

et al. 2011

Ecological Research

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To predict outbreaks of infectious disease and to prevent epidemics, it is essential not only to conduct pathological studies but also to understand the interactions between the environment, pathogen, host and humans that cause and spread infectious diseases. Outbreaks of mass mortality in carp caused by Cyprinid herpesvirus 3 (CyHV‐3), formerly known as koi herpesvirus (KHV), disease have occurred worldwide since the late 1990s. We proposed an environment–KHV–carp–human linkage as a conceptual model for “environmental diseases” and specify research subjects that might be necessary to construct and shape this linkage.

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Evolutionary Control of Infectious Disease: Prospects for Vectorborne and Waterborne Pathogens

Cited by 17 publications

References 24 publications

Virulence Genes and Neutral DNA Markers ofHelicobacter pyloriIsolates from Different Ethnic Communities of West Bengal, India

Virulence Genes and Neutral DNA Markers ofHelicobacter pyloriIsolates from Different Ethnic Communities of West Bengal, India

Parasitism, the diversity of life, and paleoparasitology

Environment–KHV–carp–human linkage as a model for environmental diseases

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