Adhesion and Co-stimulatory Molecules in the Pathogenesis of Hepatic and Intestinal Schistosomiasis Mansoni

Jacobs, Werner; Marck, Eric Van

doi:10.1590/s0074-02761998000400020

Cited by 11 publications

(12 citation statements)

References 50 publications

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“…onwards. The fibrosis pattern, in contrast to the fibrogenesis described in liver and colonic granulomas, 32 –34 formed a thin continuous band of collagen in the virtual space of the murine intestinal submucosa. In liver and colonic samples of infected mice, fibrosis was mainly detected in granulomas 33 .…”

Section: Discussionmentioning

confidence: 93%

Schistosoma mansoni infection causing diffuse enteric inflammation and damage of the enteric nervous system in the mouse small intestine

Bogers

Moreels

Man

et al. 2000

Neurogastroenterology Motil

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Schistosomiasis mansoni is a major health problem, mainly occurring in developing countries. A large proportion of infected individuals suffers from motility-related gastrointestinal problems. In the present study, the diffuse inflammatory response in the small bowel wall, as compared to the egg-induced granulomatous inflammation, was investigated. For this purpose, OF1 mice infected with Schistosoma mansoni 8-16 weeks prior to the experiment, and uninfected control mice were studied. The ileum showed both a diffuse mucosal inflammation as well as a granulomatous reaction. The diffuse mucosal inflammation caused an increase in the thickness of the mucosa, with blunting of the villi. A significant, transient increase of thickness of the muscularis propria after 12 weeks of infection was noted. There was an infection-related mast cell infiltrate in the muscularis propria, consisting of formalin fixation-insensitive connective tissue mast cells. Ganglionitis of the myenteric plexus was noted. Rarely, ganglia of the myenteric plexus contained apoptotic cells. A general pharmacological set of experiments showed a significant increase in intestinal contractility, both to exogenously administered, as well as to endogenously released neurotransmitters. Our results demonstrate that S. mansoni infection in the mouse ileum leads to diffuse specific enteric inflammation that is associated with an enhanced response to contractile agents.

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Section: Discussionmentioning

confidence: 93%

Schistosoma mansoni infection causing diffuse enteric inflammation and damage of the enteric nervous system in the mouse small intestine

Bogers

Moreels

Man

et al. 2000

Neurogastroenterology Motil

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“…6 However, experimental evidence previously obtained in the murine model of schistosomiasis mansoni also points toward the involvement of adult S. mansoni worms and their secreted antigens in the modulation of the egg antigeninduced liver granuloma and in the fibrotic response. [6][7][8][9][10][11][12] In the present work, while studying schistosomiasis-associated inflammation, interestingly we observed unexpected hepatic lesions induced by S. haematobium immature male worms in the golden hamster. Here we characterized these lesions and the nature of the local immune response by examining the hepatic inflammatory infiltrate.…”

Section: Granulomatous-like Immune Reaction and Hepatic Fibrosis Indumentioning

confidence: 74%

Granulomatous-like immune reaction and hepatic fibrosis induced bySchistosoma haematobiumimmature worms

Botelho¹,

Oliveira²,

Delgado³

et al. 2010

Virulence

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“…Granuloma formation is controlled and modulated by several cell types and protein interactions, primarily CD4+ T-cells, Th1 cytokines and cell adhesion factors [10,11]. Intercellular adhesion molecule-1 (ICAM-1) is present on endothelial cells, antigen presenting cells and fibroblasts, and belongs to the immunoglobulin superfamily of proteins [10,12]. ICAM-1 mediates granulocyte extravasation, lymphocytemediated cytotoxicity and cell-cell interactions in immunologic responses [13].…”

Section: Introductionmentioning

confidence: 99%

“…The sICAM-1 is involved in lymphocyte and eosinophil recruitment and inflammatory, immune-mediated mechanisms [14,20]. Also, sICAM-1 plays a role in modulation of the schistosome granuloma [10]. Raised levels of sICAM-1 have been observed in the serum of patients with acute and chronic liver disorders [21].…”

Section: Introductionmentioning

confidence: 99%

Serum Hyaluronic Acid (HA) and Soluble Intercellular Adhesion Molecule-1(Sicam-1) as Non-Invasive Markers of Liver Fibrosis in Viral Hepatitis, Schistosomiasis mansoni and Co-infected Patients

Ismail¹

2012

J Bacteriol Parasitol

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Background: This study aimed to correlate serum Hyaluronic Acid (HA) and soluble intercellular adhesion molecule-1 (sICAM-1), with severity of liver fibrosis as clinically and histologically assessed in viral hepatitis, schistosomiasis mansoni and co-infected patients. Methods: The study was performed on 4 groups: Group 1 (G1) 15 chronic hepatitis patients; Group 2 (G2) 15 chronic schistosomiasis mansoni co-infected with chronic hepatitis patients; Group 3 (G3) 15 chronic schistosomiasis mansoni without hepatitis patients; Group 4 (G4) 15 active schistosomiasis mansoni without hepatitis patients. Results:The results showed a significant high level of HA and sICAM-1 in all groups compared to G4, while a significantly high level of HA in G2 compared to G3. There was a highly significant positive correlation between the level of HA and sICAM-1 and between both of them, and Child-Pugh clinical classification of patients with higher levels in Child-Pugh C. Also, serum level of both HA and sICAM-1 was positively correlated to the severity of liver fibrosis assessed by biopsy, with a highly significant higher level in advanced stages 4 and 5. Conclusions: HA and sICAM-1 showed good diagnostic performance and could discriminate severe from mild liver fibrosis, enabling them to be used as valuable non-invasive markers to identify and follow up patients with liver fibrosis.

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Adhesion and Co-stimulatory Molecules in the Pathogenesis of Hepatic and Intestinal Schistosomiasis Mansoni

Abstract: Infection of a susceptible host with the blood fluke

Cited by 11 publications

References 50 publications

Schistosoma mansoni infection causing diffuse enteric inflammation and damage of the enteric nervous system in the mouse small intestine

Schistosoma mansoni infection causing diffuse enteric inflammation and damage of the enteric nervous system in the mouse small intestine

Granulomatous-like immune reaction and hepatic fibrosis induced bySchistosoma haematobiumimmature worms

Serum Hyaluronic Acid (HA) and Soluble Intercellular Adhesion Molecule-1(Sicam-1) as Non-Invasive Markers of Liver Fibrosis in Viral Hepatitis, Schistosomiasis mansoni and Co-infected Patients

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