Granulomatous-like immune reaction and hepatic fibrosis induced by<i>Schistosoma haematobium</i>immature worms

Botelho, Mónica; Oliveira, Paula A.; Delgado, Maria de Lurdes; Lourenço, L.; Lopes, Carlos; Machado, José Carlos; Costa, José Manuel Correia da

doi:10.4161/viru.1.3.11348

Cited by 8 publications

(8 citation statements)

References 24 publications

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“…Syrian hamsters can be transdermally infected with Schistosoma haematobium cercariae (140, 141). A model with Schistosoma haematobium cercariae granulomatous-like immune reaction and hepatic fibrosis infection using Syrian hamsters was generated by Botelho et al (142). Botros et al used Syrian hamster model to analyze and test praziquantel (PZQ) treatment (143).…”

Section: Syrian Hamster Used For Research In Bacterial and Parasitic mentioning

confidence: 99%

Syrian Hamster as an Animal Model for the Study on Infectious Diseases

et al. 2019

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Infectious diseases still remain one of the biggest challenges for human health. In order to gain a better understanding of the pathogenesis of infectious diseases and develop effective diagnostic tools, therapeutic agents, and preventive vaccines, a suitable animal model which can represent the characteristics of infectious is required. The Syrian hamster immune responses to infectious pathogens are similar to humans and as such, this model is advantageous for studying pathogenesis of infection including post-bacterial, viral and parasitic pathogens, along with assessing the efficacy and interactions of medications and vaccines for those pathogens. This review summarizes the current status of Syrian hamster models and their use for understanding the underlying mechanisms of pathogen infection, in addition to their use as a drug discovery platform and provides a strong rationale for the selection of Syrian hamster as animal models in biomedical research. The challenges of using Syrian hamster as an alternative animal model for the research of infectious diseases are also addressed.

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Section: Syrian Hamster Used For Research In Bacterial and Parasitic mentioning

confidence: 99%

Syrian Hamster as an Animal Model for the Study on Infectious Diseases

et al. 2019

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“…These histopathology appearances represent an early advanced feature of granuloma formation. 41 There is no report in the literature that associates S. haematobium immature worms to hepatic fibrosis. But in Schistosomiasis mansoni, Baki et al reported hepatic fibrosis and histopathological lesions in mice experimentally infected with male Schistosoma mansoni.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

“…Hepatic lesions induced by S. haematobium immature male worms were observed in the golden hamster. 41 These lesions and the nature of the local immune response were characterized by examining the hepatic inflammatory infiltrate. The induction of hepatic fibrosis and hepatitis, characteristic of egg granulomas, induced by male adult worms of S. haematobium alone is now demonstrated.…”

Section: Schistosomiasis: Aspects Of Epidemiologymentioning

confidence: 99%

Targeting molecular signaling pathways of Schistosoma haemotobium infection in bladder cancer

et al. 2011

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“…Schistosomiasis control programs are based mainly on a single drug which is praziquantel tablet [40]. Despite the fact that patients could tolerate PZQ well, it has some drawbacks including the emergence of drug resistance [4, 5], the poor efficacy on the immature stages [41], the large, bitter tablets, and the unavailability of a pediatric formula [42]. Recently, natural products and natural product-derived compounds have been popular and attracted most of the attention as it could offer new effective therapy against schistosomiasis.…”

Section: Discussionmentioning

confidence: 99%

A novel green approach for treatment of immature Schistosomiasis Mansoni infection in mice; Arabic gum (Acacia Senegal) antischistosomal properties

Selem

Rashed

Younis

et al. 2018

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Abstract. CC-BY 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/347278 doi: bioRxiv preprint first posted online Jun. 14, 2018; 26Schistosomiasis is one of the most socioeconomically exhausting parasitic 27 infection in tropical and subtropical areas. Praziquantel (PZQ), the only common 28 schistosocidal drug in use, is not efficient enough for treatment of immature infection. 29Arabic gum (AG) is a complex polysaccharide acts as anti-oxidant which modulates the Author summary 46Schistosomiasis is a major public health threat in many parts of the world, it 47 affects more than 240 million people in more than 70 countries and almost 800 million 48 people are at risk of acquiring this disease. Serious consequences and disabilities might . CC-BY 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/347278 doi: bioRxiv preprint first posted online Jun. 14, 2018;

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Granulomatous-like immune reaction and hepatic fibrosis induced bySchistosoma haematobiumimmature worms

Cited by 8 publications

References 24 publications

Syrian Hamster as an Animal Model for the Study on Infectious Diseases

Syrian Hamster as an Animal Model for the Study on Infectious Diseases

Targeting molecular signaling pathways of Schistosoma haemotobium infection in bladder cancer

A novel green approach for treatment of immature Schistosomiasis Mansoni infection in mice; Arabic gum (Acacia Senegal) antischistosomal properties

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