Unusual HPV Types in Cutaneous Warts in Association with Immunological Deficiency

Cavalcanti, Sílvia M. B.; Deus, Flávia Cristina Carvalho de; Oliveira, Ledy H. S.

doi:10.1590/s0074-02761998000400002

Cited by 4 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In relation to HPV cutaneous lesions in HIV patients, there have been reports describing one or a few cases with atypical clinical lesions, in which detection and HPV typing were performed. Lesions were caused by oncogenic genital types such as HPV 16 46 and HPV 31/33/35, 47 extragenital bowenoid papulosis by HPV 31/33/35 48 and development of spinocellular carcinoma on the wart was caused by HPV 16 49,50 . Clinical lesions similar to epidermodysplasia verruciformis have been described in HIV‐infected patients, in whose lesions were detected HPV 5, 8 and 20 51–53 .…”

Section: Discussionmentioning

confidence: 99%

Detection and typing of human papillomavirus in cutaneous warts of patients infected with human immunodeficiency virus type 1

Porro¹,

Alchorne²,

Mota

et al. 2003

Br J Dermatol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Detection and typing of human papillomavirus in cutaneous warts of patients infected with human immunodeficiency virus type 1

Porro¹,

Alchorne²,

Mota

et al. 2003

Br J Dermatol

View full text Add to dashboard Cite

show abstract

“…There are several reports in the literature of detection of HPV genital types in cutaneous lesions, especially in immunodepressed patients. 3840 In clinical lesions similar to EV in HIV-seropositive patients, types 3, 5, 8, 10 and 20 have been found, all being EV-related types. 27 In most of the EV cases studied, there was no HPV detection, as expected, since specific primers were not used for EV-related types, but generic primer with low sensibility for cutaneous lesions.…”

Section: Discussionmentioning

confidence: 97%

Human papillomavirus detection and typification in cutaneous and mucosal lesions of HIV-seropositive patients

et al. 2008

View full text Add to dashboard Cite

High-risk human papillomavirus (HPV) in a lesion is related to an increased chance of neoplasic transformation, especially when with immunosuppression, as in HIV infection. We investigated HPV frequency in cutaneous and mucosal lesions of HIV-seropositive male patients. The frequency of malignancy, its association with the HPV type detected and some clinical variables were also assessed. A total of 38 lesions from 27 patients were studied in a period of 18 months. The biopsied fragment was submitted to HPV detection and typification, through polymerase chain reaction with generic (MY09/11) and specific (types 6, 11, 16 and 18) primers. HPV frequency was 63.2%, with detection of HPV types 6, 11 or 16 in 18 lesions and with multi-infection in three. There was low detection of high-risk HPV (type 16, 18.4%) and no HPV type 18. Of the lesions, 36.8% were already premalignant or malignant, and the frequency of moderate or severe dysplasia was higher in the study patients than that described in the HIV-seronegative population. High-risk HPV (type 16) was detected in four benign lesions and low-risk HPV (type 6) in three premalignant genital lesions. There was no significant association between the clinical variables and an increase in the prevalence of premalignant or malignant lesions.

show abstract

“…There are also case reports of HIV‐positive patients presenting with pityriasis‐like lesions and unusual flat plane warts mimicking the pattern of warts found in epidermodysplasia verruciformis (EV), and EV‐associated HPV types such as HPV 5 and 8 have been isolated from these 24–26 . Genital types, particularly oncogenic types (HPV 16, 31, 33, 35) may be found in cutaneous warts in HIV‐positive individuals 27 (as cited by Porro et al. 23 ).…”

Section: What Is the Burden Of Human Papillomavirus Disease In Human mentioning

confidence: 99%

Human papillomavirus in the era of highly active antiretroviral therapy for human immunodeficiency virus: an immune reconstitution-associated disease?

Meys¹,

Gotch

Bunker³

2009

British Journal of Dermatology

View full text Add to dashboard Cite

Human immunodeficiency virus (HIV)-related cutaneous and anogenital disease in the highly active antiretroviral therapy (HAART) era presents challenging problems for dermatologists. Immune reconstitution-associated diseases (IRADs) are common and important consequences of HAART. Dermatologists should be aware of the cutaneous manifestations of IRAD. The prevalence of clinical human papillomavirus (HPV)-related disease is increased in HIV and does not appear to be diminished by HAART. Many patients on HAART are dogged by persistent cutaneous warts. Anogenital precancer is also common in HIV and may be burgeoning with HAART. Clinicians should be aware of the increased risk of cervical, penile and vulval/vaginal cancers in treated and untreated patients with HIV. The increase in HPV infection in HIV-infected individuals may be, at least partly, due to increased exposure to diverse HPV types, particularly high-risk types that might be able to persist for longer in anogenital regions. Alternatively, persistent/emergent HPV disease in HIV infection might represent persistent or modulated immunodysregulation after HAART and be viewed as a form of IRAD. The immunopathogenesis of HPV IRAD is fascinating and possibly determined by host genotype.

show abstract

Unusual HPV Types in Cutaneous Warts in Association with Immunological Deficiency

Cited by 4 publications

References 0 publications

Detection and typing of human papillomavirus in cutaneous warts of patients infected with human immunodeficiency virus type 1

Detection and typing of human papillomavirus in cutaneous warts of patients infected with human immunodeficiency virus type 1

Human papillomavirus detection and typification in cutaneous and mucosal lesions of HIV-seropositive patients

Human papillomavirus in the era of highly active antiretroviral therapy for human immunodeficiency virus: an immune reconstitution-associated disease?

Contact Info

Product

Resources

About