Immunological system and Schistosoma mansoni: co-evolutionary immunobiology. What is the eosinophil role in parasite-host relationship?

Lenzi, Henrique Leonel; Pacheco, Ronaldo Grechi; Pelajo-Machado, Marcelo; Panasco, Mônica S; Romanha, Waldemiro S; Lenzi, J. A.

doi:10.1590/s0074-02761997000800005

Cited by 22 publications

(19 citation statements)

References 87 publications

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“…It also participates in the parasite host co-evolution, operating upon parasite transmission, favoring the egg release to the feces (Lenzi et al 1987(Lenzi et al , 1997.…”

Section: Phases Of Schistosoma Mansoni Granuloma Developmentmentioning

confidence: 99%

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Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches

Lenzi¹,

Kimmel

Schechtman

et al. 1998

Mem. Inst. Oswaldo Cruz

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“…It also participates in the parasite host co-evolution, operating upon parasite transmission, favoring the egg release to the feces (Lenzi et al 1987(Lenzi et al , 1997.…”

Section: Phases Of Schistosoma Mansoni Granuloma Developmentmentioning

confidence: 99%

“…This pre-granu-lomatous phase is not very well studied and probably takes part in the definition of the infection outcome. It represents an antique memory resulted from millenary experience between S. mansoni and the hosts, that preceded the beginning of the lymphoid system (Lenzi et al 1997).…”

Section: Phases Of Schistosoma Mansoni Granuloma Developmentmentioning

confidence: 99%

Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches

Lenzi¹,

Kimmel

Schechtman

et al. 1998

Mem. Inst. Oswaldo Cruz

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“…The functional consequences of omental and mesenteric MS stimulation by S. mansoni are unknown, although some hypotheses were discussed in Lenzi et al (1992Lenzi et al ( , 1996Lenzi et al ( , 1997 and Weinberg et al (1992).…”

mentioning

confidence: 99%

Omental and pleural milky spots: different reactivity patterns in mice infected with Schistosoma mansoni reveals coelomic compartmentalisation

Panasco

Pelajo-Machado

Lenzi

2010

Mem. Inst. Oswaldo Cruz

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In vertebrate animals, pleural and peritoneal cavities are repositories of milky spots (MS), which constitute an organised coelom-associated lymphomyeloid tissue that is intensively activated by Schistosoma mansoni infection. This study compared the reactive patterns of peritoneal MS to pleural MS and concluded from histological analysis that they represent independent responsive compartments. Whole omentum, lungs and the entire mediastinum of 54 S. mansoni-infected mice were studied morphologically. The omental MS of infected animals were highly activated, modulating from myeloid-lymphocytic (60 days of infection) to lymphomyeloid (90 days of infection) and lymphocytic or lymphoplasmacytic (160 days of infection) types. The non-lymphoid component predominated in the acute phase of infection and was expressed by monocytopoietic, eosinopoietic and neutropoietic foci, with isolated megakaryocytes and small foci of late normoblasts and mast cells. Nevertheless, pleural or thoracic MS of infected mice were monotonous, consisting of small and medium lymphocytes with few mast and plasma cells and no myeloid component. Our data indicate that compartmentalisation of the MS response is dependent on the lymphatic vascularisation of each coelomic cavity, limiting the effects or consequences of any stimulating or aggressive agents, as is the case with S. mansoni infection

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“…O granuloma opera como uma interface híbrida entre dois seres filogeneticamente diferentes [um trematódeo (S. mansoni) + um hospedeiro invertebrado (molusco) ou vertebrado (homem, camundongo, outros)], tentando favorecer uma coabitação simbiótica entre eles (Lenzi et al, 1997). Ele não se forma para atacar o ser coabitante, mas serve para proteger o hospedeiro de produtos antigênicos e/ou tóxicos originados pelo agente granulomatogênico (miracídio no inte- No granuloma foram reveladas através de anticorpo contra ocludina (= fosfoproteína integral de membrana que interage com uma proteína transmembranosa da célula adjacente, chamada claudina) (Lenzi & Romanha, submetido) 3-Moléculas de adesão dependentes de Ca 2 como as caderinas, que juntam célula-célula.…”

Section: Teleologia Ou Finalidade Do Granulomaunclassified

Modelagem em Biomatemática

2004

Notas Em Matemática Aplicada

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Immunological system and Schistosoma mansoni: co-evolutionary immunobiology. What is the eosinophil role in parasite-host relationship?

Cited by 22 publications

References 87 publications

Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches

Histoarchitecture of schistosomal granuloma development and involution: morphogenetic and biomechanical approaches

Omental and pleural milky spots: different reactivity patterns in mice infected with Schistosoma mansoni reveals coelomic compartmentalisation

Modelagem em Biomatemática

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