Contrasting Genomic Variability between Clones from Field Isolates and Laboratory Populations of Schistosoma mansoni

Cercarial Chaetotaxy and Sex Differentiation of Schistosoma mansoni Deriving from Humans and Nectomys squamipes (Muridae: Sigmondontinae) in Brazil

“…This observation is consistent with the results obtained with sympatric isolates of H or murine origin from Senegal, where the analysis of isoenzymes was used (Sène et al 1997). It has been demonstrated, through the use of DNA analysis, that strains that are geographically close present homology (Pillay & Pillay 1994, Pinto et al 1997. Even the strains that are geographically different present over 90% similarity (Pillay & Pillay 1994).…”

Experimental models of Schistosoma mansoni infection

“…Rapid changes in isoenzyme patterns occur during successive generations of newly isolated S. mansoni strains in mice so that it is clear that genetic selection may occur rapidly in the laboratory (LoVerde et al 1985, Bremond et al 1993. Pinto et al (1997) recently documented the greater genetic variability in worms from field isolates compared to the LE strain long maintained in the laboratory. Passage in the molluscan host may also result in genetic selection of the worms (Richards & Shade 1987).…”