Biological comparison between three clones of Trypanosoma cruzi and the strain of origin (Bolivia) with reference to clonal evolution studies

Abstract

After isolating three clones of

Polymorphism in Trypomastigotes of Trypanosoma (Megatrypanum) minasense in the blood of experimentally infected squirrel monkey and marmosets

“…The morphological variations showed by T. minasense during the course of the experimental infections reported here may be due to polymorphism as previously described in other species as (Brener 1979, Urdaneta-Morales 1983, Penin et al 1996 as well as in several African trypanosome species (Miles 1970, Hoare 1972, Ormerod et al 1974, Nantulya et al 1978, Ormerod 1979, Barry et al 1979, Evans & Brightman 1980, Vickerman 1985. There is much controversy regarding the biological significance of polymorphism in the genus Trypanosoma and the mechanisms which control it.…”

Characterization of a Trypanosoma rangeli Strain of Colombian Origin

“…Indeed, authors working with bloodstream trypomasytigotes and non-professional phagocytic cells like VERO or BEMS cells (Bertelli & Brener 1980), fibroblasts (Kongtong & Inoki 1975), primary heart or skeletal muscle cells ) pointed out to the need of at least 9-24 hr of parasite contact to obtain indexes varying between 1 and 9% of infected cells, depending on the parasite strain used. Comparative studies between T. rangeli and T. cruzi strains are controversial due to the heterogeneity of clonal populations within a T. cruzi strain (Deane et al 1984, Dvorak 1984, Tibayrenc & Ayala 1988, De Diego et al 1991, Penin et al 1996.…”

Are genotypes of Trypanosoma cruzi involved in the challenge of chagasic cardiomyopathy?

“…The considerable biochemical and medical heterogeneity of T. cruzi has been shown (Bre nieÁ re et al 1984;Dvorak 1984;Tibayrenc et al 1986Tibayrenc et al , 1990Tibayrenc and Ayala 1988;De Diego et al 1991;Penin et al 1996), the main question being whether the high level of clonal diversity might be responsible for all or part of this variability (Tibayrenc and Ayala 1987). It is reasonable to expect that this genetic heterogeneity will be expressed phenotypically in dierent ways.…”