An outbreak of dengue in the State of Ceará, Brazil

Souza, Rogério Valls de; Cunha, Rivaldo Venâncio da; Miagostovich, Marize Pereira; Timbó, Maria J.; Montenegro, Fernanda; Pessoa, Eni T. F. Paula; Nogueira, Rita Maria Ribeiro; Schatzmayr, Hermann G.

doi:10.1590/s0074-02761995000300006

Cited by 21 publications

(18 citation statements)

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“…In Brazil, atypical manifestations of dengue infection, such as hepatitis, myocarditis and encephalitis, have been observed during epidemics that occurred in Ceará in 1994, in the state of Pernambuco in 1997 and in Campos in 2005 [4,7,8].…”

Section: Discussionmentioning

confidence: 99%

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The impact of dengue on liver function as evaluated by aminotransferase levels

Souza¹,

Nogueira²,

Soares³

et al. 2007

Braz J Infect Dis

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The objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols. Degrees of liver damage were classified according to aminotransferase levels: grade A -normal enzyme levels; grade B -increased levels of at least one of the enzymes; grade C -increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D -acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue at the dengue referral center in Campos dos Goytacazes in the state of Rio de Janeiro, Brazil, 65.1% had abnormal aminotransferase levels: 81 cases being classified as grade B, 25 as grade C and 3 as grade D. A further 34.9% of cases had normal enzyme levels and were classified as grade A. Liver damage is a common complication of dengue infection and aminotransferase levels are a valuable marker for monitoring these cases.

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Section: Discussionmentioning

confidence: 99%

“…Atypical forms have been described in Brazil as a whole and in the state of Rio de Janeiro, in particular [4,5].…”

mentioning

confidence: 99%

The impact of dengue on liver function as evaluated by aminotransferase levels

Souza¹,

Nogueira²,

Soares³

et al. 2007

Braz J Infect Dis

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“…However the increasing number of reported cases of dengue fever/dengue haemorrhagic fever (DF/ DHF) in Brazil , Zagne et al 1994, Souza et al 1995, Vasconcelos et al 1995 showed the need for new approaches to diagnosis. Various protocols of polymerase chain reaction (PCR) have offered obvious advantages for the detection of dengue virus (Deubel et al 1990, Morita et al 1991, Pao et al 1992, Seah et al 1995.…”

mentioning

confidence: 99%

Diagnosis of Dengue by Using Reverse Transcriptase-Polymerase Chain Reaction

Miagostovich¹,

Santos²,

Araújo³

et al. 1997

Mem. Inst. Oswaldo Cruz

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“…This sub-notification along with the appearance of dengue haemorrhagic fever (DHF) cases in the state (Souza et al 1995, Vasconcelos et al 1995, suggests that the official numbers of reported cases are underestimated, since DHF represents only the tip of iceberg of many other cases of dengue infection (Gubler 1987).…”

Section: Discussionmentioning

confidence: 99%

“…Then, in 1988it increased to 70.8% and in 1992dropped to 46% (FNS 1992 Mac-Elisa (LACEN 1994). In the following month, DEN-2 virus was isolated by the Flavivirus Laboratory, Institute Oswaldo Cruz (Souza et al 1995). DEN-1 virus was also isolated in Ceará during 1994 showing the co-circulation of both serotypes in the state (Vasconcelos et al 1995).…”

mentioning

confidence: 99%