The impact of dengue on liver function as evaluated by aminotransferase levels

Souza, Luíz José de; Nogueira, Rita Maria Ribeiro; Soares, Leandro Cordeiro; Soares, Carlos Eduardo Cordeiro; Ribas, Bruno Fernandes; Alves, Felipe Pinto; Vieira, Fabíola Rodrigues; Pessanha, Felipe Eulálio Baldi

doi:10.1590/s1413-86702007000400007

Cited by 66 publications

(66 citation statements)

References 11 publications

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“…In relation with the clinical manifestation investigation, which could be associated with hepatic function disorders (nausea and vomiting, abdominal pain and hepatomegaly), there were no significant differences among those patients with altered enzymes (AST and ALT) and those who had enzyme dosage within the normal range. These results agree with those observed in other studies 1,4,[11][12][13] .…”

Section: Serology Resultssupporting

confidence: 94%

Clinical and laboratory findings in patients with dengue associated with hepatopathy

Nascimento

Castro

Froes

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: Hepatic disorders caused by dengue infection may progress to severe manifestations, including mortality and morbidity. Cytokines are involved in it, such as the migration inhibitory factor of macrophages (MIF), tumor necrosis factor (TNF), natural killer cells (NK), B lymphocytes, and macrophages. Methods: This study was carried out from January to April 2007 at a public hospital from the Federal University of Mato Grosso do Sul, Campo Grande, Brazil. Sixty-eight patients were studied concerning hepatic alterations, with 56 reported having classic dengue, 6 with hemorrhagic dengue grade I, and 6 with hemorrhagic dengue grade II. Results: Among the 56 with classic dengue, 83.3% had aspartate aminotransferase (AST) alterations, and 69.6% had altered alanine aminotransferase (ALT). For those with hemorrhagic dengue grade I, 100% had AST alterations, and 83.3% had altered ALT. All the patients with hemorrhagic dengue grade II had AST and ALT alterations. AST variations reached 22.0 and 907.0, with an average value of 164.6. For ALT, we found variations between 25.0 and 867.0, with an average value of 166.07. There had been statistical significance between dengue clinical shapes and hepatic function markers. Conclusions: We conclude that the infection was predominant in adults, females, and in those with low income and education. The liver enzymes were of larger amount in hemorrhagic dengue, but there was weak statistical evidence of the clinical manifestations and transaminases. Major signs and clinical symptoms were fever, headache, myalgia, arthralgia, weakness, severe pain behind the eyes, and rashes.

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Section: Serology Resultssupporting

confidence: 94%

Clinical and laboratory findings in patients with dengue associated with hepatopathy

Nascimento

Castro

Froes

et al. 2011

Rev. Soc. Bras. Med. Trop.

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“…Our laboratory data showed that the percentage of dengue patients with mean elevated level of Aspartate transaminase and Alanine transaminase were significantly higher than that of laboratory dengue negative patients. Previous studies suggested that liver injury is a common finding in dengue infections and it is mediated by direct infection of hepatocytes and Kupffer cells (Murgue et al, 1999;Souza et al, 2007). Recently, Luiz et al suggested the use of markers such as Aspartate transaminase and Alanine transaminase as parameters to evaluate severity in patients with dengue fever (Luiz et al, 2004).…”

Section: Journal Of Virology and Microbiologymentioning

confidence: 99%

Demographic and Clinical Features of Patients with Dengue in Northeastern Region of India: A Retrospective Cross-Sectional Study during 2009-2011

Dutta¹,

Khan²,

Borah³

et al. 2012

JVM

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The incidence of fever cases of unknown origin has increased in Northeastern Region of India in recent years. We conducted passive surveillance and performed laboratory testing on suspected cases for the presence of dengue infection during 2009-2011. We estimated the incidence by applying age, sex and season adjusted dengue positivity. We identified 430 suspected cases of which 143 (33.3%) were found to be laboratory-confirmed dengue cases. Dengue transmission was found to occur in post-monsoon season (September-December). We evaluated the differences of clinical features and hematologic abnormalities that occurred in laboratory dengue positive and negative cases. Significantly higher percentage of dengue patients had headache, eye pain and vomiting (P < 0.05). Diarrhoea as well as abdominal pain was observed more commonly in laboratory dengue negative patients but the difference was not significant (P > 0.05). Thrombocytopenia was observed in significantly higher percentage of positive patients (P < 0.001) with significantly lower platelets counts (P < 0.001). The elevated level of Aspartate transaminase (P < 0.001) and Alanine transaminase (P = 0.002) was also significantly higher side in positive patients. This study provides some important information in clinical and laboratory data that can be used for early diagnosis and subsequently for appropriate treatment of dengue infections. Thus, the passive surveillance and laboratory confirmation provides a better estimate of the actual dengue disease burden and a scope to further refine dengue prevention strategies.

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“…Upon admission, the levels of AST, ALT, and serum alkaline phosphatase were elevated in 87% of children with hepatomegaly and in 81% of children without hepatomegaly. Hepatic dysfunction is a well-recognized feature of dengue infection and often manifests as hepatomegaly and mild to moderate increases in transaminase levels; jaundice and acute liver failure generally occur less commonly 14 . Kabra et al 11 evaluated 240 children aged between 4 months and 13 years who were admitted to a hospital in India with a clinical diagnosis of dengue infection.…”

mentioning

confidence: 99%

Dengue infection in children and adolescents: Clinical profile in a reference hospital in northeast Brazil

Neto

Pinho

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de Medicina Tropical 46(6):765-768, Nov-Dec, 2013http://dx.doi. org/10.1590/0037-8682-1716-2013 Dengue infection in children and adolescents: Clinical profi le in a reference hospital in northeast Brazil ABSTRACT Introduction:This study aimed to describe the clinical spectrum of dengue in children and adolescents from a hyperendemic region who were admitted for hospitalization. Methods: A retrospective study was conducted on patients diagnosed with dengue infection upon admission to a reference center in Fortaleza, Brazil. Results: Of the 84 patients included, 42 underwent confi rmatory testing. The main symptoms were fever, abdominal pain and vomiting. The median level of serum aspartate aminotransferase was 143.5±128mg/dL. Conclusions: A peculiar clinical profi le was evident among children and adolescents with dengue infection in a reference center in northeast Brazil, including gastrointestinal symptoms and liver involvement.

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The impact of dengue on liver function as evaluated by aminotransferase levels

Cited by 66 publications

References 11 publications

Clinical and laboratory findings in patients with dengue associated with hepatopathy

Clinical and laboratory findings in patients with dengue associated with hepatopathy

Demographic and Clinical Features of Patients with Dengue in Northeastern Region of India: A Retrospective Cross-Sectional Study during 2009-2011

Dengue infection in children and adolescents: Clinical profile in a reference hospital in northeast Brazil

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