Milky spots reactions to schistosomal mansoni infection

Oliveira, Denise N.; Borojević, Radovan; Lenzi, J. A.

doi:10.1590/s0074-02761992000900017

Cited by 8 publications

(3 citation statements)

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“…The MS response correlates with leukocyte influx in the dialysate. In a chronic rabbit model, although less pronounced, the same pattern of changes in MS has been observed (20). In line with these observations, studies in man (13,14) have indicated that MS numbers increase during inflammation and during PD (21).…”

Section: Discussionsupporting

confidence: 56%

Omental Milky Spots in Peritoneal Pathophysiology (Spots before your Eyes)

et al. 2005

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Section: Discussionsupporting

confidence: 56%

Omental Milky Spots in Peritoneal Pathophysiology (Spots before your Eyes)

et al. 2005

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“…The functional consequences of omental and mesenteric MS stimulation by S. mansoni are unknown, although some hypotheses were discussed in Lenzi et al (1992Lenzi et al ( , 1996Lenzi et al ( , 1997 and Weinberg et al (1992).…”

mentioning

confidence: 99%

Omental and pleural milky spots: different reactivity patterns in mice infected with Schistosoma mansoni reveals coelomic compartmentalisation

Panasco

Pelajo-Machado

Lenzi

2010

Mem. Inst. Oswaldo Cruz

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In vertebrate animals, pleural and peritoneal cavities are repositories of milky spots (MS), which constitute an organised coelom-associated lymphomyeloid tissue that is intensively activated by Schistosoma mansoni infection. This study compared the reactive patterns of peritoneal MS to pleural MS and concluded from histological analysis that they represent independent responsive compartments. Whole omentum, lungs and the entire mediastinum of 54 S. mansoni-infected mice were studied morphologically. The omental MS of infected animals were highly activated, modulating from myeloid-lymphocytic (60 days of infection) to lymphomyeloid (90 days of infection) and lymphocytic or lymphoplasmacytic (160 days of infection) types. The non-lymphoid component predominated in the acute phase of infection and was expressed by monocytopoietic, eosinopoietic and neutropoietic foci, with isolated megakaryocytes and small foci of late normoblasts and mast cells. Nevertheless, pleural or thoracic MS of infected mice were monotonous, consisting of small and medium lymphocytes with few mast and plasma cells and no myeloid component. Our data indicate that compartmentalisation of the MS response is dependent on the lymphatic vascularisation of each coelomic cavity, limiting the effects or consequences of any stimulating or aggressive agents, as is the case with S. mansoni infection

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“…During schistosomiasis, C. callosus present an omental reactivity in milky spots with patches that represent subsidiary foci of lymphomyeloid tissue-associated coelom (CALT), which was also observed in mice [ 95 , 96 ]. S. mansoni worms live predominantly in mesenteric vessels, and consequently, their released products can reach the mesenteric and omental microcirculation, which leads to CALT [ 97 ].…”

Section: Schistosomiasismentioning

confidence: 99%

Calomys callosus: An Experimental Animal Model Applied to Parasitic Diseases Investigations of Public Health Concern

et al. 2022

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The appearance and spread of parasitic diseases around the world aroused the interest of the scientific community to discover new animal models for improving the quality and specificity of surveys. Calomys callosus is a rodent native to South America, an easy handling model, with satisfactory longevity and reproducibility. C. callosus is susceptible to toxoplasmosis and can be used as experimental model for the study the pathogenesis, treatment, vertical transmission, and ocular toxoplasmosis. C. callosus can also be used to study cutaneous and visceral leishmaniasis, as the animals present cutaneous lesions, as well as parasites in the organs. C. callosus has epidemiological importance in Chagas disease, and since it is a Trypanosoma cruzi natural host in which rodents show high parasitemia and lethality, they are also effective as a model of congenital transmission. In the study of schistosomiasis, Schistosoma mansoni was proven to be a C. callosus natural host; thus, this rodent is a great model for fibrosis, hepatic granulomatous reaction, and celloma associated with lymphomyeloid tissue (CALT) during S. mansoni infection. In this review, we summarize the leading studies of parasitic diseases that used C. callosus as a rodent experimental model, describing the main uses and characteristics that led them to be considered an effective model.

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Milky spots reactions to schistosomal mansoni infection

Cited by 8 publications

References 0 publications

Omental Milky Spots in Peritoneal Pathophysiology (Spots before your Eyes)

Omental Milky Spots in Peritoneal Pathophysiology (Spots before your Eyes)

Omental and pleural milky spots: different reactivity patterns in mice infected with Schistosoma mansoni reveals coelomic compartmentalisation

Calomys callosus: An Experimental Animal Model Applied to Parasitic Diseases Investigations of Public Health Concern

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