Extracellular matrix and schistosomiasis

Andrade, Zilton A.

doi:10.1590/s0074-02761991000700010

Cited by 6 publications

(5 citation statements)

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“…It has been demonstrated that Gram-positive organisms avidly bind to matrix-protein-coated surfaces, and S. aureus, in particular, aggregates in the presence of fibronectin, laminin, and type IV collagen (Vercellotti et al 1985). As for collagen-associated proteoglycans, fibronectin is abundant during the more active stages of the granuloma (Andrade 1991). This suggests that S. aureus might adhere to compounds of the extracellular matrix of the granulomata of S. mansoni, e.g.…”

Section: Discussionmentioning

confidence: 99%

“…This suggests that S. aureus might adhere to compounds of the extracellular matrix of the granulomata of S. mansoni, e.g. collagen, fibronectin and proteoglycans (Andrade 1991), and, consequently, liver abscesses can be formed. In addition, the formation and degradation of extracellular matrix and laminin of the chronic granuloma (Andrade & Grimaud 1988) may also be implicated in the pathogenesis of the abscesses.…”

Section: Discussionmentioning

confidence: 99%

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Schistosomiasis mansoni is asssociated with pyogenic liver abscesses in the state of Minas Gerais, Brazil

Teixeira¹,

Pfeilsticker²,

Cecília³

et al. 2001

Mem. Inst. Oswaldo Cruz

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Schistosomiasis mansoni is asssociated with pyogenic liver abscesses in the state of Minas Gerais, Brazil

Teixeira¹,

Pfeilsticker²,

Cecília³

et al. 2001

Mem. Inst. Oswaldo Cruz

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“…22 As for collagen-associated proteoglycans, fibronectin is abundant during the more active stages of the granuloma. 23 This suggest that compounds of the extracellular matrix of the granulomas of S. mansoni, e.g., collagen, fibronectin and proteoglycans, 23 could be involved in adherence of S. aureus. In addition, some compounds of the chronic granulomas formed by the balance between the formation and degradation of extracellular matrix and laminin 24 might also be implicated in the pathogenesis of the abscesses.…”

Section: Discussionmentioning

confidence: 99%

Pathogenic aspects of pyogenic liver abscess associated with experimental schistosomiasis.

Teixeira

Coelho²,

Filho³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

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Abstract. Schistosomiasis mansoni infection that occurs concurrently with Staphylococcus aureus bacteremia favors the formation of pyogenic liver abscess. The present experimental study in mice evaluated the following aspects of the relationship between infection with Schistosoma mansoni and liver abscess caused by S. aureus: a) the role of the eggs of S. mansoni in the genesis of the abscesses; b) the influence of different phases of schistosomiasis in the development of liver abscesses; and c) the effect of the treatment of schistosomiasis on the development of the abscesses. Macroscopic and histopathological study showed multiple liver abscesses around granulomas of S. mansoni in the acute and chronic phases of schistosomiasis. Treatment of acute schistosomiasis before experimentally-induced bacteremia did not prevent the formation of liver abscess. The study findings indicate that granulomas around S. mansoni eggs and worms lodged in the liver provide a focus and substrate for pyogenic abscesses caused by S. aureus.

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“…Schistosomiasis has been used as a model for the study of granuloma biology, with Schistosoma mansonii eggs stimulating the production of extracellular matrix and the formation of protective granulomas (1,2). Infection by Mycobacterium tuberculosis results in the production of granulomas that simultaneously inhibit the spread of the organism and offer a safe environment for microbial persistence.…”

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confidence: 99%

The wound repair response controls outcome to cutaneous leishmaniasis

Sakthianandeswaren

Elso

Simpson

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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Chronic microbial infections are associated with fibrotic and inflammatory reactions known as granulomas showing similarities to wound-healing and tissue repair processes. We have previously mapped three leishmaniasis susceptibility loci, designated lmr1, -2, and -3, which exert their effect independently of T cell immune responses. Here, we show that the wound repair response is critically important for the rapid cure in murine cutaneous leishmaniasis caused by Leishmania major. Mice congenic for leishmaniasis resistance loci, which cured their lesions more rapidly than their susceptible parents, also expressed differentially genes involved in tissue repair, laid down more ordered collagen fibers, and healed punch biopsy wounds more rapidly. Fibroblast monolayers from these mice repaired in vitro wounds faster, and this process was accelerated by supernatants from infected macrophages. Because these effects are independent of T cell-mediated immunity, we conclude that the rate of wound healing is likely to be an important component of innate immunity involved in resistance to cutaneous leishmaniasis.fibroblasts ͉ leishmania ͉ macrophages ͉ resistance ͉ wound healing

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Extracellular matrix and schistosomiasis

Cited by 6 publications

References 0 publications

Schistosomiasis mansoni is asssociated with pyogenic liver abscesses in the state of Minas Gerais, Brazil

Schistosomiasis mansoni is asssociated with pyogenic liver abscesses in the state of Minas Gerais, Brazil

Pathogenic aspects of pyogenic liver abscess associated with experimental schistosomiasis.

The wound repair response controls outcome to cutaneous leishmaniasis

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