Extracellular matrix and schistosomiasis

Andrade, Zilton A.

doi:10.1590/s0074-02761991000700010

Cited by 6 publications

(5 citation statements)

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“…Due to being that Gram-positive bacteria actively bind to matrix-protein-coated surfaces, Staphylococcus species might adhere to laminin, fibronectin and type IV cpllagen which are compounds of extracellular matrix of granulomas produced by trematodes (Andrade, 1991) and consequently liver abscesses may be formed. Furthermore, formation and degradation of extracellular matrix of chronic granulomas may be also implicated in the pathogenesis of abscesses (Andrade and Grimaud, 1988).…”

Section: Discussionmentioning

confidence: 99%

Some parasitic and bacterial causes of liver affections in ruminants

El‐Dakhly

Hassan

Lotfy³

2008

Journal of Veterinary Medical Research

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In the present study, a total number of 1576 livers of ruminants, including cattle (924), sheep (487) and camels (165) were examined for detection of different pathogenic agents. Among those, a number of 58 cases (3.68 %) were infected with both parasites and bacteria. Out of this number, 3 cases only (0.19 %) were infected with bacterial species (Lactobacillus lactis lactis), 31 cases (1.97 %) were infected with parasitic stages only and a number of 24 cases (1.52 %) were co-infected with both bacteria and parasites. Among the bacterial isolates, 11 genera of bacterial species were found in 27 cases. The obtained results revealed that, all infected cases were cattle. The most prevalent isolate was Enterococcus species which present in 7 cases (25.92 %) among the totally bacterial infected cases, followed by 5 cases showed Staphylococci (18.52 %), then both genus Escherichia and genus Lactobacillus, each was found in 4 cases (14.81 %) and finally 7 genera including; Enterobacter, Micrococcus, Citrobacter, Aerococcus, Pseudomonas, Chrysomonas and Streptococcus; each was found in a single case with a percentage of 3.70 %. Concerning the parasitic affections, it has been found that Fasciola species was the most prevalent type of helminthes present in the infected livers. Among all infected livers, 40 cases (2.54 %) were infected with adult Fasciola gigantica (including 33 cattle and 7 sheep), followed by 8 cases of camels (0.51 %) infected with Hydatid cysts, then 4 cases of sheep (0.25 %) infected with Cysticercus tenuicollis and finally 3 cases of sheep (0.19 %) infected with both Fasciola gigantica and Cysticercus tenuicollis. The results revealed that, a considerable high number of co-infected animals {24 cases (41.38 %) among the totally infected animals} was existed and this reveals that the parasite facilitates the way to the secondary bacterial infection with the end results of hepatic tissue degeneration and necrosis. So, in abattoirs, great attention must be taken for appropriate evaluation of these pathogenic sources. 66BS. VET. MED. J. 5 TH SCI. CONF.

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Section: Discussionmentioning

confidence: 99%

Some parasitic and bacterial causes of liver affections in ruminants

El‐Dakhly

Hassan

Lotfy³

2008

Journal of Veterinary Medical Research

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“…It has been demonstrated that Gram-positive organisms avidly bind to matrix-protein-coated surfaces, and S. aureus, in particular, aggregates in the presence of fibronectin, laminin, and type IV collagen (Vercellotti et al 1985). As for collagen-associated proteoglycans, fibronectin is abundant during the more active stages of the granuloma (Andrade 1991). This suggests that S. aureus might adhere to compounds of the extracellular matrix of the granulomata of S. mansoni, e.g.…”

Section: Discussionmentioning

confidence: 99%

“…This suggests that S. aureus might adhere to compounds of the extracellular matrix of the granulomata of S. mansoni, e.g. collagen, fibronectin and proteoglycans (Andrade 1991), and, consequently, liver abscesses can be formed. In addition, the formation and degradation of extracellular matrix and laminin of the chronic granuloma (Andrade & Grimaud 1988) may also be implicated in the pathogenesis of the abscesses.…”

Section: Discussionmentioning

confidence: 99%

Schistosomiasis mansoni is asssociated with pyogenic liver abscesses in the state of Minas Gerais, Brazil

Teixeira¹,

Pfeilsticker²,

Cecília³

et al. 2001

Mem. Inst. Oswaldo Cruz

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“…22 As for collagen-associated proteoglycans, fibronectin is abundant during the more active stages of the granuloma. 23 This suggest that compounds of the extracellular matrix of the granulomas of S. mansoni, e.g., collagen, fibronectin and proteoglycans, 23 could be involved in adherence of S. aureus. In addition, some compounds of the chronic granulomas formed by the balance between the formation and degradation of extracellular matrix and laminin 24 might also be implicated in the pathogenesis of the abscesses.…”

Section: Discussionmentioning

confidence: 99%

Pathogenic aspects of pyogenic liver abscess associated with experimental schistosomiasis.

Teixeira

Coelho²,

Filho³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

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Abstract. Schistosomiasis mansoni infection that occurs concurrently with Staphylococcus aureus bacteremia favors the formation of pyogenic liver abscess. The present experimental study in mice evaluated the following aspects of the relationship between infection with Schistosoma mansoni and liver abscess caused by S. aureus: a) the role of the eggs of S. mansoni in the genesis of the abscesses; b) the influence of different phases of schistosomiasis in the development of liver abscesses; and c) the effect of the treatment of schistosomiasis on the development of the abscesses. Macroscopic and histopathological study showed multiple liver abscesses around granulomas of S. mansoni in the acute and chronic phases of schistosomiasis. Treatment of acute schistosomiasis before experimentally-induced bacteremia did not prevent the formation of liver abscess. The study findings indicate that granulomas around S. mansoni eggs and worms lodged in the liver provide a focus and substrate for pyogenic abscesses caused by S. aureus.

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Extracellular matrix and schistosomiasis

Cited by 6 publications

References 0 publications

Some parasitic and bacterial causes of liver affections in ruminants

Some parasitic and bacterial causes of liver affections in ruminants

Schistosomiasis mansoni is asssociated with pyogenic liver abscesses in the state of Minas Gerais, Brazil

Pathogenic aspects of pyogenic liver abscess associated with experimental schistosomiasis.

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