Bioactivity of neolignans from fructus Schizandrae

Li, Xiaoyü

doi:10.1590/s0074-02761991000600010

Cited by 27 publications

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“…Treatment with Schisandrin C synthetic analogue ( DDB ) , significantly recovered both liver weight , TL and TP to a non -significant difference from control , although TP didn't return to the control value , but only improved by drug treatment . This probably necessitated a longer treatment period for complete recovery , because DDB treatment was proved in other situations to initiate both protein and glycogen synthesis in CCl4 -intoxicated rats and protected liver tissue by membrane stabilization (Li ,1991 ) .In the present results , CCl4 significantly increased both tissue TC and TG , while decreased PL contents .Treatment with DDB , significantly reversed this effect and recovered the three parameters near to normal control values. CCl4 was known to interfere with the hepatic PL synthesis (Recknagel et al , 1976 ) and to decrease liver plasma membrane PL content in both acute and chronic treatments (Camacho and Rubalcava ,1984 ) .…”

Section: Discussionmentioning

confidence: 49%

Diphenyl dimethyl bicarboxylate as an effective treatment for chemical-induced fatty liver in rats

Abdel-Hamid¹

2009

African Journal of Biomedical Research

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Section: Discussionmentioning

confidence: 49%

Diphenyl dimethyl bicarboxylate as an effective treatment for chemical-induced fatty liver in rats

Abdel-Hamid¹

2009

African Journal of Biomedical Research

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“…20,21) Pharmacological studies revealed that lignans isolated from Schisandra chinesis show anti-cancer, anti-hepatotoxic, anti-oxidative, and anti-inflammatory activities. [22][23][24] Gomisin A, for example, has several pharmacological activities, including anticancer and cancer chemopreventive potential in animal models. [25][26][27] Tumor necrosis factor-α (TNF-α) causes a hemorrhagic necrotic effect against implanted solid tumors.…”

Section: 11)mentioning

confidence: 99%

Gomisin A Enhances Tumor Necrosis Factor-α-Induced G1 Cell Cycle Arrest <i>via</i> Signal Transducer and Activator of Transcription 1-Mediated Phosphorylation of Retinoblastoma Protein

Waiwut

Shin

Yokoyama

et al. 2012

Biological & Pharmaceutical Bulletin

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Gomisin A, a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra chinensis, has been reported as an anti-cancer substance. In this study, we investigated the effects of gomisin A on cancer cell proliferation and cell cycle arrest in HeLa cells. Gomisin A significantly inhibited cell proliferation in a dose-dependent manner after 72 h treatment, especially in the presence of tumor necrosis factor-α (TNF-α), due to cell cycle arrest in the G1 phase with the downregulation of cyclin D1 expression and Retinoblastoma (RB) phosphorylation. In addition, gomisin A in combination with TNF-α strongly suppressed the expression of signal transducer and activator of transcription 1 (STAT1). Inhibition of STAT1 pathways by a small-interfering RNA against STAT1 and AG490 Janus kinase (JAK) kinase inhibitor AG490 reduced the cyclin D1 expression and RB phosphorylation, indicating that JAK-mediated STAT1 activation is involved in gomisin A-induced G1 cell cycle arrest.Key words gomisin A; tumor necrosis factor-α; cell cycle; cyclin D1; Retinoblastoma Cancer cells often have a selective growth advantage due to deregulation of cell cycle proteins, causing aberrant growth signaling that drives tumor development.1-4) The eukaryotic cell cycle is regulated through the sequential activation and inactivation of cyclin-dependent kinases (CDKs). Deregulation of G1 to S-phase transition is implicated in the pathogenesis of most human cancers. 5) Retinoblastoma protein (RB) is a critical target protein in G1-S checkpoint control. Phosphorylation of RB by CDK/cyclin complex results in the release of active E2F transcription factor to stimulate the transcription of genes involved in DNA synthesis and S-phase progression. 6,7)Cyclin D1 can accelerate the progress of cells through the G1 phase by binding to CDKs and subsequently phosphorylating RB. Overexpression of cyclin D1 has been shown to shorten the G1 phase in cancer cells and is most frequently associated with human cancer. 8,9) Cyclin D1 is rarely mutated, but its overexpression confers a selective growth advantage and hence acts as a driver of neoplastic growth in various cancers. 10,11)The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays a significant role in various physiological processes, including immune function, cell growth, differentiation, and hematopoiesis. 12) Constitutive activation of STAT3 correlates with cell proliferation in breast carcinoma 13) and non small-cell lung cancer.14) It has been revealed that inhibition of JAK-STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells.15) Activated STAT3 correlates with elevated cyclin D1 protein in primary breast tumors and breast cancer-derived cell lines.16) Our recent study demonstrated that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis was enhanced by STAT1 knockdown.17) Consequently, regulation of STATs can be considered as a key major target in controlling the gr...

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“…We previously reported schisandrin B (SchB) as the first example of a specific inhibitor of ATR in DNA damage checkpoint signaling (10). SchB is the major lignan isolated from Schisandra chinensis, one of the most frequently used herbs in traditional Chinese medicines (11,12), and it has subsequently been revealed to be a mixture of gomisin N (GN) and -schisandrin (-Sch), which are the diastereomers of each other (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

Differential Effect of Schisandrin B Stereoisomers on ATR-Mediated DNA Damage Checkpoint Signaling

Tatewaki

Nishida

Yoshida³

et al. 2013

J Pharmacol Sci

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Abstract.We have previously reported that schisandrin B (SchB) is a specific inhibitor of ATR (ataxia telangiectasia and Rad-3-related) protein kinase. Since SchB consists of a mixture of its diastereomers gomisin N (GN) and -schisandrin (-Sch), the inhibitory action of SchB might result from a stereospecific interaction between one of the stereoisomers of SchB and ATR. Therefore, we investigated the effect of GN and -Sch on UV (UVC at 254 nm)-induced activation of DNA damage checkpoint signaling in A549 cells. UV-induced cell death (25 -75 J/m 2 ) was amplified by the presence of the diastereomers, especially GN. At the same time, GN, but not -Sch, inhibited the phosphorylation of checkpoint proteins such as p53, structural maintenance of chromosomes 1, and checkpoint kinase 1 in UV-irradiated cells. Moreover, GN inhibited the G2/M checkpoint during UV-induced DNA damage. The in vitro kinase activity of immunoaffinity-purified ATR was dose-dependently inhibited by GN (IC 50 : 7.28 M) but not by -Sch. These results indicate that GN is the active component of SchB and suggest that GN inhibits the DNA damage checkpoint signaling by stereospecifically interacting with ATR.

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Bioactivity of neolignans from fructus Schizandrae

Cited by 27 publications

References 0 publications

Diphenyl dimethyl bicarboxylate as an effective treatment for chemical-induced fatty liver in rats

Diphenyl dimethyl bicarboxylate as an effective treatment for chemical-induced fatty liver in rats

Gomisin A Enhances Tumor Necrosis Factor-α-Induced G1 Cell Cycle Arrest <i>via</i> Signal Transducer and Activator of Transcription 1-Mediated Phosphorylation of Retinoblastoma Protein

Differential Effect of Schisandrin B Stereoisomers on ATR-Mediated DNA Damage Checkpoint Signaling

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