Diphenyl dimethyl bicarboxylate as an effective treatment for chemical-induced fatty liver in rats

Abdel-Hamid, Nabil Mohie

doi:10.4314/ajbr.v9i2.48778

Cited by 5 publications

(4 citation statements)

References 10 publications

(11 reference statements)

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“…These findings agree with previous results that found that CCl4 treatment significantly increased liver tissue weight, total lipid, TC, TG where CCl4 is induced fatty liver where lipogenesis is produced [30].…”

Section: Discussionsupporting

confidence: 93%

“…The results related to the deleterious effect of CCl4 itself and its metabolites; CCl4 is metabolized by the cytochrome P-450. CCl4 metabolite trichloromethyl free radicals reacted with protein and lipid within the cell; this reaction accelerated with oxygen and yielded trichloromethyl peroxyl radicals, which attack lipids on the membrane of endoplasmic reticulum faster than trichloromethyl free radical disturbed calcium homeostasis and finally cell death [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Avocado (Persea Americana), Cabbage (Brassica Oleracea) and Ginger (Zingiber Officinale) on Rat Liver and Thyroid Injuries Induced by CCl4 (Carbon Tetrachloride)

Hamouda¹,

Sameeh²,

Shrourou³

2016

JPP

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Avocado, Cabbage, and Ginger are a part of a regular human diet and have antioxidant, and antitumor effects. The effect of AVOE (avocado), GE (Ginger) and CE (Cabbage) extracts separately on liver NO (nitric oxide), MDA (malondialdehyde), as well as serum AST (aspartate aminotransferase), ALT (alanine aminotransferase), total bilirubin, TC (total cholesterol), T.G (triglyceride), HDL cholesterol (high-density lipoprotein), LDL cholesterol (low-density lipoprotein), TSH (thyroid-stimulating hormone), T3 (Triiodothyronine), T4 (Thyroxine) in rats treated and untreated with CCl4 (carbon tetrachloride) was studied. The levels of NO, MDA, as well as serum AST, ALT, total bilirubin, TC, T.G, LDL, and TSH, showed an elevation while, HDL, T3 and T4 showed the decline in rats treated with CCl4 as compared to control. Treatment of rats with AVOE and GE pre, during, and post CCl4 administration improve NO, MDA, as well as serum AST, ALT, total bilirubin, TC, T.G, HDL, LDL, TSH, T3, T4 as compared to CCl4. Treatment of rats with CE pre, during, and post CCl4 administration did not improve in the thyroid hormones and lipid profile levels as compared to CCl4. These findings suggest that avocado and ginger treatment exerts a protective effect on metabolic disorders by decreasing oxidative stress.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Effect of Avocado (Persea Americana), Cabbage (Brassica Oleracea) and Ginger (Zingiber Officinale) on Rat Liver and Thyroid Injuries Induced by CCl4 (Carbon Tetrachloride)

Hamouda¹,

Sameeh²,

Shrourou³

2016

JPP

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“…CCl 4 is the most recognized chemical substance used in developing models of liver and kidney damage [5] , [6] . Therefore, CCl 4 -induced liver damage is one of the best ways of inducing damage by xenobiotics and also one of the common methods of screening hepatoprotective or liver treatment drugs.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of methanolic Tanacetum parthenium extract on CCl4-induced liver damage in rats

2017

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“…A significant loss of body weight was observed in the negative control group compared to the control group accompanied with reduced food consumption. An increase in liver weight is common in the case of CCl 4 intoxication due to fatty changes [37].…”

Section: Discussionmentioning

confidence: 99%

Cichotyboside, A Sesquiterpene Glycoside from Cichorium intybus Attenuates Carbon Tetrachloride-Induced Liver Injury in Rat

Singh¹,

Bigoniya²

2022

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Aims: Cichorium intybus L. is traditionally used for the management of the various liver disorders and also widely scientifically reported for hepatoprotection. The present study aims at investigating cichotyboside, bioactive sesquiterpene glycoside, from seeds for hepatoprotective effect against carbon tetrachloride (CCl 4 ) following isolation and characterization. Methods: Cichotyboside was isolated from C. intybus seeds and characterized by infrared spectroscopy (IR), liquid chromatography-mass spectrometry (LC/MS), and carbon 13 nuclear magnetic resonance ( 13 C NMR). High-performance liquid chromatography (HPLC) and high-performance thin-layer chromatography (HPTLC) have been developed for the standardization of Cichotyboside. In this study, biochemical assays, liver functional capacity restoration regarding drug metabolism, antioxidant potential, and histological staining were applied to evaluate the anti-hepatotoxic efficacy of cichotyboside on a carbon tetrachloride induced liver injury in rats. Results: The results showed that cichotyboside could significantly attenuate the pathological changes, increase the levels of hepatocyte repair, and regulate oxidative damage. Hepatoprotective activity of cichotyboside is indicated by its ability to decrease thiopental induced sleeping time, increased BSP clearance, reverse effect of CCl 4 on the body weight, relative liver weight, serum liver function parameters, histopathology and activity of liver antioxidant enzymes. Conclusion: Cichotyboside exerts hepatoprotective activity against the CCl 4 induced toxicity, possibly by its remarkable antioxidant potential, reversing the impaired metabolisms and repairing the fatty changes in hepatocytes.

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Diphenyl dimethyl bicarboxylate as an effective treatment for chemical-induced fatty liver in rats

Abstract: To assess the protective effect of diphenyl dimethyl bicarboxylate (DDB)

Cited by 5 publications

References 10 publications

Effect of Avocado (Persea Americana), Cabbage (Brassica Oleracea) and Ginger (Zingiber Officinale) on Rat Liver and Thyroid Injuries Induced by CCl4 (Carbon Tetrachloride)

Effect of Avocado (Persea Americana), Cabbage (Brassica Oleracea) and Ginger (Zingiber Officinale) on Rat Liver and Thyroid Injuries Induced by CCl4 (Carbon Tetrachloride)

Hepatoprotective effect of methanolic Tanacetum parthenium extract on CCl4-induced liver damage in rats

Cichotyboside, A Sesquiterpene Glycoside from Cichorium intybus Attenuates Carbon Tetrachloride-Induced Liver Injury in Rat

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