Sequential infection as risk factor for dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) during the 1981 dengue hemorrhagic cuban epidemic

Guzmán, María G.; Kourı́, Gustavo; Bravo, José; Soler, Maritza; Martínez, Eric

doi:10.1590/s0074-02761991000300011

Cited by 37 publications

(25 citation statements)

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“…Primary infection with any of the four serotypes results in lifelong immunity to the same serotype but leaves the individual susceptible to sequential secondary infections by heterologous serotypes (7). Epidemiological studies in Cuba and Southeast Asia have shown a strong association between secondary dengue infection and DHF (8,9). These data indicate that previous immunity to dengue may be a risk factor in the development of severe dengue disease (10,11).…”

mentioning

confidence: 97%

Dengue Virus-Reactive CD8+ T Cells Display Quantitative and Qualitative Differences in Their Response to Variant Epitopes of Heterologous Viral Serotypes

Bashyam

Green

Rothman

2006

The Journal of Immunology

124

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Reactivation of serotype cross-reactive CD8+ memory T lymphocytes is thought to contribute to the immunopathogenesis of dengue disease during secondary infection by a heterologous serotype. Using cytokine flow cytometry, we have defined four novel HLA-A*02-restricted dengue viral epitopes recognized by up to 1.5% of circulating CD8+ T cells in four donors after primary vaccination. All four donors had the highest cytokine response to the epitope NS4b 2353. We also studied the effect of sequence differences in heterologous dengue serotypes on dengue-reactive CD8+ memory T cell cytokine and proliferative responses. The D3 variant of a different NS4b epitope 2423 and the D2 variant of the NS4a epitope 2148 induced the largest cytokine response, compared with their respective heterologous sequences in all donors regardless of the primary vaccination serotype. Stimulation with variant peptides also altered the relative frequencies of the various subsets of cells that expressed IFN-γ, TNF-α, MIP-1β, and combinations of these cytokines. These results indicate that the prior infection history of the individual as well as the serotypes of the primary and heterologous secondary viruses influence the nature of the secondary response. These differences in the effector functions of serotype cross-reactive memory T cells induced by heterologous variant epitopes, which are both quantitative and qualitative, may contribute to the clinical outcome of secondary dengue infection.

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confidence: 97%

Dengue Virus-Reactive CD8+ T Cells Display Quantitative and Qualitative Differences in Their Response to Variant Epitopes of Heterologous Viral Serotypes

Bashyam

Green

Rothman

2006

The Journal of Immunology

124

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“…The pathogenesis of DHF/DSS is not well understood, but epidemiological observations suggest that severe disease occurs more frequently in the setting of secondary infection with heterologous dengue virus serotypes (11,25). Ennis and coworkers (15,21) have proposed a model for the immunopathogenesis of DHF/DSS in which dengue virus-specific memory T cells from a previous infection are activated by infected monocytes or macrophages via major histocompatibility complex (MHC)-restricted presentation of heterologous dengue virus epitopes to produce cytokines, including gamma interferon (IFN-␥), which upregulate expression of cell surface Fc␥R.…”

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confidence: 99%

Differential Functional Avidity of Dengue Virus-Specific T-Cell Clones for Variant Peptides Representing Heterologous and Previously Encountered Serotypes

Imrie¹,

Meeks

Gurary

et al. 2007

J Virol

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Proinflammatory cytokines secreted by memory CD8؉ and CD4 ؉ T cells are thought to play a direct role in the pathogenesis of dengue virus infection by increasing vascular permeability and thereby inducing the pathophysiologic events associated with dengue hemorrhagic fever and dengue shock syndrome. Severe disease is frequently observed in the setting of secondary infection with heterologous dengue virus serotypes, suggesting a role for cross-reactive memory T cells in the immunopathogenesis of severe disease. We used a large panel of well-characterized dengue virus-specific CD8 ؉ T-cell clones isolated from Pacific Islanders previously infected with dengue virus 1 to examine effector memory function, focusing on a novel dominant HLA-B*5502-restricted NS5 329-337 epitope, and assessed T-cell responses to stimulation with variant peptides representing heterologous serotypes. Variant peptides were differentially recognized by dengue virus 1-specific effector CD8

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“…there is no cross-immunity of serotypes, except in the course of the first weeks or months following the infection (Martínez, 1998). However, when a person has sub-neutralizing Ig against one of the dengue viruses and is infected by another viral serotype, an infrequent response is produced, one that is almost exclusive of the infection by dengue: an antibody-dependent amplification (ada) that is expressed in an enhanced viral replication and an increase in the viremia, which promotes and favors the development of the severe form of the illness (Guzmán et al, 1992;Halstead, 2002).…”

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confidence: 99%

Dengue

Torres

2008

Estud. av.

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El dengue es hoy la más importante arbovirosis, por su gran carga de enfermedad e implicaciones sociales. El mosquito Aedes aegypti, su principal transmisor convive con el hombre en su hábitat domestico y peridoméstico. El cuadro clínico es de fiebre, cefalea, dolor retroocular, dolores corporales, exantema y mucho decaimiento. El enfermo puede empeorar súbitamente y presentar choque por dengue, con grandes hemorragias digestivas y elevada mortalidad. No existe droga antiviral, pero la muerte puede evitarse mediante la infusión intravenosa precoz de soluciones cristaloides. Algunos candidatos vacunales están actualmente en ensayo clínico. La prevención depende del control del vector, mediante educación sanitaria y reordenamiento ambiental.

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Sequential infection as risk factor for dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) during the 1981 dengue hemorrhagic cuban epidemic

Cited by 37 publications

References 0 publications

Dengue Virus-Reactive CD8+ T Cells Display Quantitative and Qualitative Differences in Their Response to Variant Epitopes of Heterologous Viral Serotypes

Dengue Virus-Reactive CD8+ T Cells Display Quantitative and Qualitative Differences in Their Response to Variant Epitopes of Heterologous Viral Serotypes

Differential Functional Avidity of Dengue Virus-Specific T-Cell Clones for Variant Peptides Representing Heterologous and Previously Encountered Serotypes

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