Dengue

Torres, Eric

doi:10.1590/s0103-40142008000300004

Cited by 26 publications

(15 citation statements)

References 41 publications

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“…It was also determined that 26 patients had platelet counts of ≥ 100 0000/mm 3 , no significant changes of arterial pressure and no severe haemorrhagic manifestations, and they were therefore classified as having mild dengue. Another 24 patients had thrombocytopenia (platelet levels of < 100 0000/mm 3 ) and arterial or postural hypotension, and had received parenteral hydration for at least 6 hr; these patients were classified as having severe dengue, matching previous criteria used for adults in South and Central America 17–19 …”

Section: Resultsmentioning

confidence: 99%

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Differential regulation of toll‐like receptor‐2, toll‐like receptor‐4, CD16 and human leucocyte antigen‐DR on peripheral blood monocytes during mild and severe dengue fever

et al. 2010

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SummaryDengue fever (DF), a public health problem in tropical countries, may present severe clinical manifestations as result of increased vascular permeability and coagulation disorders. Dengue virus (DENV), detected in peripheral monocytes during acute disease and in in vitro infection, leads to cytokine production, indicating that virus-target cell interactions are relevant to pathogenesis. Here we investigated the in vitro and in vivo activation of human peripheral monocytes after DENV infection. ing that these cells might be involved in controlling exacerbated inflammatory responses, probably by IL-10 production. We showed here, for the first time, phenotypic changes on peripheral monocytes that were characteristic of cell activation. A sequential monocyte-activation model is proposed in which DENV infection triggers TLR2/4 expression and inflammatory cytokine production, leading eventually to haemorrhagic manifestations, thrombocytopenia, coagulation disorders, plasmatic leakage and shock development, but may also produce factors that act in order to control both intense immunoactivation and virus replication.

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Section: Resultsmentioning

confidence: 99%

“…, 15 who studied a group of Nicaraguan patients with severe dengue, who had signs of shock that did not fit the DHF/DSS classification, and designated this disease category as dengue with signs associated with shock. Other studies support an alternative classification for severity of dengue in adults 17–19 …”

Section: Methodsmentioning

confidence: 95%

Differential regulation of toll‐like receptor‐2, toll‐like receptor‐4, CD16 and human leucocyte antigen‐DR on peripheral blood monocytes during mild and severe dengue fever

et al. 2010

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“… 3 , 4 It is currently the most important arbovirus in the world in terms of morbidity, mortality, and economic burden. 5 In South America, the disease became rare in the 1970s because of the eradication of the mosquito vector as a result of efforts to control yellow fever, another arbovirosis. 6 However, when the eradication program ended, Ae.…”

Section: Introductionmentioning

confidence: 99%

Costs of Dengue to the Health System and Individuals in Colombia from 2010 to 2012

Rodríguez¹,

Galera-Gelvez²,

Yescas³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Dengue fever (DF) is an important health issue in Colombia, but detailed information on economic costs to the healthcare system is lacking. Using information from official databases (2010–2012) and a face-to-face survey of 1,483 households with DF and dengue hemorrhagic fever (DHF) patients, we estimated the average cost per case. In 2010, the mean direct medical costs to the healthcare system per case of ambulatory DF, hospitalized DF, and DHF (in Colombian pesos converted to US dollars using the average exchange rate for 2012) were $52.8, $235.8, and $1,512.2, respectively. The mean direct non-medical costs to patients were greater ($29.7, $46.7, and $62.6, respectively) than the mean household direct medical costs ($13.3, $34.8, and $57.3, respectively). The average direct medical cost to the healthcare system of a case of ambulatory DF in 2010 was 57% of that in 2011. Our results highlight the high economic burden of the disease and could be useful for assigning limited health resources.

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“…Com relação ao sintoma 'presença de vômitos', deveria ser considerado um sinal de alarme quando: os vômitos fossem persistentes com três ou mais episódios em uma hora ou houver cinco ou mais episódios em seis horas 18 . Assim, na análise dos dados, 57 indivíduos classificados como dengue clássica e como dengue com sinal de alarme, apresentaram vômitos como sinal de alarme registrado, contudo não evoluíram para gravidade.…”

Section: Discussionunclassified

Comparação da gravidade dos casos de dengue segundo a classificação antiga e a classificação revisada

Luz

Araújo

Santos

et al. 2018

Rev. Med. (São Paulo)

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Introdução: Existem duas classificações que estratificam os casos de dengue pelo quadro clínico laboratorial: a classificação proposta nos anos 50 e a revisada pela Organização Mundial de Saúde, adotada em janeiro de 2014 no Brasil. Compará-las quanto à capacidade de identificar a gravidade do caso representa nosso objetivo. Métodos: Estudo observacional e transversal com análise e comparação dos casos de dengue de 2011 a 2013 de um hospital terciário de referência da cidade de Natal/RN, de acordo com a classificação antiga e a classificação revisada. As correspondências adotadas foram: Dengue Clássica e Febre Hemorrágica da Dengue (DHF) grau I com Dengue; DHF grau II com Dengue com sinais de alarme; DHF grau III e IV com Dengue grave. Resultados: 2.318 fichas foram analisadas, com a população predominantemente adulta, média de idade 30,32 anos ± 17,89, sendo 39% do sexo masculino, 61% do sexo feminino. A partir das correlações designadas, 428 casos foram concordantes, 699 discordantes e 1191 “sem classificação” (casos cujos dados dos prontuários não possibilitaram sua classificação). Conclusões: As duas classificações foram equivalentes no manejo clínico quando os casos de dengue foram graves. A classificação antiga evita a superestimação de casos leves e moderados por utilizar mais aspectos clínicos e laboratoriais que a classificação revisada. Sangramento de mucosa, dor abdominal e vômitos não representaram sinais que evoluíram para gravidade, demonstrando como a utilização dos sinais de alarme de maneira imprecisa pode superestimar os dados.

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Dengue

Cited by 26 publications

References 41 publications

Differential regulation of toll‐like receptor‐2, toll‐like receptor‐4, CD16 and human leucocyte antigen‐DR on peripheral blood monocytes during mild and severe dengue fever

Differential regulation of toll‐like receptor‐2, toll‐like receptor‐4, CD16 and human leucocyte antigen‐DR on peripheral blood monocytes during mild and severe dengue fever

Costs of Dengue to the Health System and Individuals in Colombia from 2010 to 2012

Comparação da gravidade dos casos de dengue segundo a classificação antiga e a classificação revisada

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