Isolation of dengue virus type 2 in Rio de Janeiro

Nogueira, Rita Maria Ribeiro; Miagostovich, Marize Pereira; Lampe, E.; Schatzmayr, H. G.

doi:10.1590/s0074-02761990000200022

Cited by 74 publications

(60 citation statements)

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“…The virus was isolated in cell culture and the serotype was identified in the Flavivirus Laboratory of the Oswaldo Cruz Institute/FIOCRUZ, as previously described by Nogueira et al [2].…”

Section: Isolation Of the Virusmentioning

confidence: 99%

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The impact of dengue on liver function as evaluated by aminotransferase levels

Souza¹,

Nogueira²,

Soares³

et al. 2007

Braz J Infect Dis

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The objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols. Degrees of liver damage were classified according to aminotransferase levels: grade A -normal enzyme levels; grade B -increased levels of at least one of the enzymes; grade C -increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D -acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue at the dengue referral center in Campos dos Goytacazes in the state of Rio de Janeiro, Brazil, 65.1% had abnormal aminotransferase levels: 81 cases being classified as grade B, 25 as grade C and 3 as grade D. A further 34.9% of cases had normal enzyme levels and were classified as grade A. Liver damage is a common complication of dengue infection and aminotransferase levels are a valuable marker for monitoring these cases.

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“…The virus was isolated in cell culture and the serotype was identified in the Flavivirus Laboratory of the Oswaldo Cruz Institute/FIOCRUZ, as previously described by Nogueira et al [2].…”

Section: Isolation Of the Virusmentioning

confidence: 99%

“…After ingestion of infected blood, the mosquito is able to transmit the virus following an extrinsic incubation period of 8-12 days. In the state of Rio de Janeiro, serotypes 1, 2 and 3 have already been isolated [1][2][3]. Dengue virus type 3 (DENV-3) was isolated for the first time in December 2000 and was the principal agent of the 2002 epidemic.…”

mentioning

confidence: 99%

The impact of dengue on liver function as evaluated by aminotransferase levels

Souza¹,

Nogueira²,

Soares³

et al. 2007

Braz J Infect Dis

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“…Após um silêncio epidemiológico, o sorotipo DEN-1 invadiu o Sudeste (Rio de Janeiro) e Nordeste (Alagoas, Ceará, Pernambuco, Bahia, Minas Gerais) em 1986-1987 2 17 , espalhando pelo país desde então, com as entradas dos sorotipos DEN-2 em 1990-1991 13 , e o DEN-3 em 2001-2002 12 . No momento, estes três sorotipos circulam simultaneamente em 24 estados da Federação 18 , contribuindo para a incidência das formas graves da dengue (dengue hemorrágica e síndrome do choque da dengue) nas cidades onde se registraram epidemias sequenciais por pelo menos dois sorotipos diferentes 5 , embora a virulência da cepa epidêmica possa ser algumas vezes o determinante principal das formas hemorrágicas 10 16 20 .…”

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Estudo retrospectivo (histórico) da dengue no Brasil: características regionais e dinâmicas

Câmara

Theophilo

Santos

et al. 2007

Rev. Soc. Bras. Med. Trop.

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A dengue é hoje objeto da maior campanha de saúde pública do Brasil, que se concentra no controle do Ae aegypti, único vetor reconhecido como transmissor do vírus da dengue em nosso meio. Este mosquito está adaptado a se reproduzir nos ambientes doméstico e peridoméstico 21 ABSTRACT Dengue epidemics occur typically in the warmest months without qualitative differences for the Brazilian geographic regions. However, this disease has an important quantitative difference. We observe two clusters in the country regarding the number of case notifications: The first cluster is formed by the North-East and South-East regions, that sum about 86% of the all notifications; and the second is formed by the

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“…DEN-1 was the only serotype circulating in the country until 1990, when dengue virus type 2 (DEN-2) was also introduced (Nogueira et al 1990). During the last decade, dengue epidemics have been recorded annually in the country and the number of reported cases has shown dengue infection to be an increasing public health problem (Figueiredo 1996) The circulation of dengue viruses in the Americas, including dengue virus type 3 (DEN-3) which reappeared in the region (Nicaragua and Panama) in 1994 (CDC 1995) after an absence of 16 years, represents a real threat of new dengue epidemics in the country.…”

mentioning

confidence: 99%