Evidence of enterovirus 71 infections in Brazil

Ee, Da Silva; Am, Fillipis; Hg, Schatzmayr; Lc, Cortes

doi:10.1590/s0074-02761990000100025

Cited by 15 publications

(12 citation statements)

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“…It is also possible that in the period in which the Japanese evaluation was done, circulation of EV 71 was extremely low and perhaps restricted to a determined country. In Brazil studies involving EV 71 were carried out by da Silva et al (1990) and Takimoto et al (1998) both relating that this viruses to motor disorder occurred in the states of Bahia, Goiás, Piauí, São Paulo and Federal District, different from our study that involved patients with fever and exanthem. These authors detected positivity to EV 71 in 32.1% (9/28) and 5.6% (24/426) of the cases respectively.…”

Section: Discussioncontrasting

confidence: 60%

“…The non-polio enteroviruses (NPEV) are the main responsible for aseptic meningitis, myocarditis and nonspecific febrile exanthematous illnesses. Approximately 75% of infections by EV occur in children under 15 years of age and the attack rates are highest in children under 1 year of age (Wiedbrank & Johnston 1993).EV 71, one of the last NPEV studied, was described for the first time by NJ Schimidt et al (da Silva et al 1990) in 1974, in California, associated with cases of the central nervous system (CNS) diseases. In the same year Kennett et al (1974) Bulgaria with clinical symptoms of poliomyelitis, encephalitis, encefalomyocarditis and aseptic meningitis.…”

mentioning

confidence: 99%

“…Many enteroviruses were isolated from the 238 cases, approximately half of them were EV 71 (Wang et al 1998). In Brazil the first evidence of infections by EV 71 was mentioned by da Silva et al (1990); these authors studied cases of acute flaccid paralysis (AFP) and finding neutralizing antibodies (NtAb) for EV 71 in 32.1% of serum samples. In another study developed by da Silva et al (1996) positive IgM to EV 71 was detected in 20 (21%) of 92 children living in different areas of Brazil that presented clinical symptoms of AFP over a 3 year-old period (1988 to 1990).…”

mentioning

confidence: 99%

“…Takimoto et al (1998) detected positivity for EV 71 in 5.6% of the 426 samples of children's feces with symptoms of acute neurological disease (AND), residents in the State of São Paulo and in the city of Brasília. Despite the significant variability of clinical and epidemic manifestations, there is close antigenic similarity among strains of EV 71 isolated in different countries (da Silva et al 1990), justifying its study in several aspects including seroprevalence. On this subject Hagiwara et al (1979) in the 70s showed interesting results including reference to circulation of EV 71 in Japan in 1966.…”

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confidence: 99%

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Neutralizing Antibodies to Enterovirus 71 in Belém, Brazil

Gomes¹,

Castro

Oliveira

et al. 2002

Mem. Inst. Oswaldo Cruz

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Non-polio enteroviruses (Coxsackievirus A, Coxsackievirus B, At the beginning of this century, motor deficiency cases could be related to pathogens such as viruses and particularly to polioviruses, which belong to the enterovirus (EV) genus, Picornaviridae family. Besides the poliovirus (3 serotypes), EV includes Coxsackievirus A (23 serotypes: types 1-17, 19-22 and 24), Coxsackievirus B (6 serotypes), Echovirus (30 serotypes): 1-7, 9, 11-27, 29-33), and EV 68-72 (Wiedbrank & Johnston 1993).Enteroviruses are non-enveloped small viruses (20-30 nm) of icosahedral symmetry. Their RNA genomes have 7.5 kb, positive sense and single strand. They are responsible for an extensive variety of diseases, although 50 to 80% of the infections are asymptomatic. They cause hepatitis, pleurodinia, stomatitis and neonatal sepsis in a significant number of patients every year. In developing countries, the poliovirus is clinically the most significant member of the genus EV causing paralysis diseases in every 4 out of 1,000 children in school age. The non-polio enteroviruses (NPEV) are the main responsible for aseptic meningitis, myocarditis and nonspecific febrile exanthematous illnesses. Approximately 75% of infections by EV occur in children under 15 years of age and the attack rates are highest in children under 1 year of age (Wiedbrank & Johnston 1993).EV 71, one of the last NPEV studied, was described for the first time by NJ Schimidt et al. (da Silva et al. 1990) in 1974, in California, associated with cases of the central nervous system (CNS) diseases. In the same year Kennett et al. (1974) Bulgaria with clinical symptoms of poliomyelitis, encephalitis, encefalomyocarditis and aseptic meningitis. Ninetytwo strains of EV 71 were isolated from the 65 cases with the same symptomatology of the poliomyelitis, including 37 strains from brain and medulla, 1 from cerebrospinal fluid, 10 from mesenterial lymph nodes and tonsils and 44 from feces (Chumakov et al. 1979). An outbreak of infections caused by EV 71 occurred in Australia during the winter of 1986. Of the 114 studied patients, 65 were hospitalized and 33 frequently had CNS involvement associated to severe symptoms (Gilbert et al. 1988). During an outbreak of hand, foot and mouth disease (HFMD) in Malaysia, in 1997, 4 children developed cardiopulmonary collapse and neurological problems. All the children received cardiopulmonary resuscitation but died. Postmortem studies showed infection by EV 71, with extensive damage to the medulla and pons (Lum et al. 1988). More recently the EV 71 was responsible for an epidemic occurred in Taiwan. Most of the patients had HFMD with or without complications. Many enteroviruses were isolated from the 238 cases, approximately half of them were EV 71 (Wang et al. 1998). In Brazil the first evidence of infections by EV 71 was mentioned by da Silva et al. (1990); these authors studied cases of acute flaccid paralysis (AFP) and finding neutralizing antibodies (NtAb) for EV 71 in 32.1% of serum samples. In another study developed by da Silv...

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Section: Discussioncontrasting

confidence: 60%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Neutralizing Antibodies to Enterovirus 71 in Belém, Brazil

Gomes¹,

Castro

Oliveira

et al. 2002

Mem. Inst. Oswaldo Cruz

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“…Se conocen varios serotipos de ENP con habilidad para causar cuadros paralíticos similares al producido por el virus polio, como son: Coxsackie A7(CA7), Coxsackie A16, enterovirus 70 (EV70), Echo 7(EC7), pero el más frecuentemente asociado a estos ha sido el enterovirus 71 (EV71) (1,2,4,(11)(12)(13)(14)(15).…”

Section: Introductionunclassified