Prevalence of human T cell leukemia virus-I (HTLV-I) antibody among populations living in the Amazon region of Brazil (preliminary report)

Nakauchi, Célia Maria; Linhares, Alexandre da Costa; Maruyama, Koshi; Kanzaki, Luis Isamu Barros; Macedo, João Emílio; Azevedo, Vânia Nakauth; Casseb, Jorge

doi:10.1590/s0074-02761990000100004

Cited by 22 publications

(12 citation statements)

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“…These results were also similar to those obtained from risk groups as blood recipients in endemic areas (13.5%), intravenous drug abusers (9.0%) and other cancer patients-23.2% (17,20,24). Therefore, these renal transplanted patients may be included in a high risk group of HTLV-1 infection.…”

supporting

confidence: 87%

“…is not common in urban populations in this region of North-east of Brazil. The low percentage of seropositivity of the healthy populations does not indicate endemicity of HTLV-1 although other studies suggest that the infection is frequent in other regions of Brazil (7,11,12,17).…”

mentioning

confidence: 76%

“…In the Amazon region of North Brazil, none of the 44 Japanese immigrants were positive for HTLV-1, despite the seroprevalence related with cancer patients (23.2%) living in urban area and Indian communities (31.4%) (16,17).…”

mentioning

confidence: 99%

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Human T Cell Leukemia Virus Type 1 (HTLV‐1) Antibodies in Healthy Populations and Renal Transplanted Patients in the North‐East of Brazil

Linhares

Eizuru

Andrade

et al. 1994

Microbiology and Immunology

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The seroprevalence of human T cell leukemia virus type 1 (HTLV-1) infection was investigated in Brazilians (570): native inhabitants (298) and descendants from Japanese (272) living in Recife and its neighborhoods-North-east of Brazil. Furthermore, polytransfused renal transplanted patients (54) were also examined for the serological status to this virus. The seropositivity to HTLV-1, screened by enzyme-linked immunosorbent assay (ELISA), was low: 1.34% for the local population and 0.73% for the descendants from Japanese. However, the seropositivity for the renal transplanted patients was found to be 11.1%. This higher value suggests that this retrovirus infection seems to be of importance in this clinical condition.

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confidence: 87%

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confidence: 76%

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Human T Cell Leukemia Virus Type 1 (HTLV‐1) Antibodies in Healthy Populations and Renal Transplanted Patients in the North‐East of Brazil

Linhares

Eizuru

Andrade

et al. 1994

Microbiology and Immunology

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“…In the Amazon region of Brazil, HTLV-1 and HTLV-2 infections were primarily described [63,[84][85][86], and soon their geographical dissemination expanded [6]. In 1998, HTLV-2 was detected for the first time outside native Indian communities, and both viruses were found in blood donors [82] and HIV-1 carriers [50].…”

Section: Detection Of Htlv In the Amazon Region Of Brazilmentioning

confidence: 99%

The challenge of describing the epidemiology of HTLV in the Amazon region of Brazil

Ishak

Vallinoto

2020

Retrovirology

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HTLV-1 was the first described human retrovirus and was soon found to be associated with severe clinical diseases, including a devastating lymphoma/leukemia and other inflammatory diseases. Although HTLV-2 is not usually pathogenic, it is widely distributed among native Indian populations in Brazil, particularly in the Amazon region of the country. Presently, HTLV spreads mainly by the sexual route and from mother to child, and virus persistence is an active biological factor aiding its transmission. Recently, the use of illicit drugs has been shown to be an additional risk factor, showing the influence of new habits on the epidemiology of HTLV in the region. Despite the detection of the virus in several different populations in the Amazon region of Brazil for almost 30 years, the exact prevalence of HTLV-1/2 is not well defined. The original biases in sampling and the selection of epidemiologically unsuitable populations were commonly repeated in most prevalence studies, generating unreliable and conflicting figures that do not represent the actual prevalence of HTLV. The improvements in clinical and laboratory facilities have resulted in the description of several clinical manifestations that were previously unknown in the region. The extent of the spread of the virus must be defined in this region, which is the largest geographical area of the country. As prophylaxis advances toward the use of vaccines against HTLV-1, it is important to determine who is at risk of being infected and developing a disease to successfully implement preventive measures, particularly as proposals are made to eradicate the virus among humans.

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“…In the Amazon Basin, Nakauchi et al 17 registered high incidence of HTLV-l antibodies in serum for natives (10-39%) and for patients with neoplasies (about 23%). In the present study serum and CSF, were tested in patients of three risk groups.…”

Section: Other Antibodies -Hiv Antibodies Were Detected (Serum and Csmentioning

confidence: 99%

HTLV-1 antibodies in serum and cerebrospinal fluid in tropical spastic paraparesis in Brazil

Spina-França

Livramento

Machado

et al. 1990

Arq. Neuro-Psiquiatr.

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SUMMARY -HTLV-l antibodies were investigated in serum and in CSF of 150 patients with neurologic disorders mainly myelopathies. The patients were considered into three groups according to the possible relationship of their disease to the presence of HTLV-l antibodies: no relationship risk (control group), occasional risk group, and possible risk group. In this latter are 56 patients with crural spastic paraparesis or paraplegia of unknown etiology (SP). HTLV-l antibodies were tested by the passive particle-agglutination method for anti-ATLA antibody detection. The search was negative in all patients of the control group, and positive (serum and/or CSF) in 16.5% of the patients from the second group and in 55.4% of the SP patients group. Clinical patterns in SP cases with HTLV-l antibodies were those of tropical spastic paraparesis (TSP). CSF patterns considered (cytology, protein content and gamma-globulins rate) were different between TSP group with HTLV-l antibodies in CSF and SP group with no HTLV-l antibodies detection either in serum or in CSF. The difference was significant. Results of this investigation confirm the high incidence of TSP in Brazil, and bring additional indication for searching HTLV-l antibodies in the CSF.HTLV-l anticorpos no soro e no liquido cefalorraqueano na paraparesis espástica tropical no Brasil.RESUMO -Foi pesquisada a presença de HTLV-l anticorpos no soro e no LCR de 150 pacientes com afeccões do sistema nervoso, particularmente mielopatias. Os pacientes foram considerados segundo três grupos, de acordo com a possível relação entre a doença e a presença de HTLV-l anticorpos: sem risco de relação (grupo controle); grupo de risco ocasional; grupo de risco possível. Este último abrange 56 pacientes com paraparesia ou paraplegia crural espástica de etiologia não esclarecida (PE). Foi utilizada para a pesquisa a técnica de aglutinação passiva de partículas para anti-ATLA anticorpo, sendo obtidos os seguintes resultados: não foram detectados HTLV-l anticorpos no grupo controle e foram detectados (soro e/ou LCR) em 16,5% dos pacientes do segundo grupo e em 55,4% daqueles do terceiro grupo. O quadro clínico dos pacientes com PE e HTLV-l anticorpos era compatível a paraparesia espática tropical (PET). Foi verificada diferença significativa quanto a dados do exame de LCR (citologia, concentração proteica e teor de globulinas gama) ao se compararem os pacientes com PET com HTLV-l anticorpos no LCR àqueles com PE em que tais anticorpos não foram detectados nem no soro e nem no LCR. Os resultados deste estudo confirmam a elevada incidência da PET no Brasil o ilustram a necessidade da pesquisa desses anticorpos também no LCR.In the last five years it has been emphasized the retrovirus HTLV-l serumposivity in several groups of patients with crural spastic paraparesis or paraplegia (SP). The HTLV-l antibodies were searched once in each case in CSF (150) and in serum samples (97). Passive particle-agglutination technic for anti-ATLA antibody detection (Fujirebio, Japan) was used. As preconized, se...

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Prevalence of human T cell leukemia virus-I (HTLV-I) antibody among populations living in the Amazon region of Brazil (preliminary report)

Cited by 22 publications

References 0 publications

Human T Cell Leukemia Virus Type 1 (HTLV‐1) Antibodies in Healthy Populations and Renal Transplanted Patients in the North‐East of Brazil

Human T Cell Leukemia Virus Type 1 (HTLV‐1) Antibodies in Healthy Populations and Renal Transplanted Patients in the North‐East of Brazil

The challenge of describing the epidemiology of HTLV in the Amazon region of Brazil

HTLV-1 antibodies in serum and cerebrospinal fluid in tropical spastic paraparesis in Brazil

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