Influência da terapêutica específica na prevenção e reversão das formas graves da esquistossomose

Morbidity associated with Schistosoma mansoni infection determined by ultrasound in an endemic area of Brazil, Caatinga do Moura.

“…1,3,14 Since periodic treatment with schistosomicidal drugs has reduced the prevalence of the most severe forms of schistosomiasis, the evaluation of schistosomiasis morbidity by clinical examination is losing its predictive value. 9,[15][16][17] Previous studies demonstrate the usefulness of ultrasonography in determination of schistosomiasis morbidity by comparing the ultrasonographic findings with liver biopsy 18,19 and hemodynamic parameters. 13 The present study shows a direct correlation between the PT1 and portal vein diameter, PT1 and proximal spleen vein diameter, and PT1 and spleen size, validating the ultrasonographic classification of hepatic fibrosis.…”

Schistosomiasis control in Brazil

“…Almost all treated patients were found to be re-infected after two years of follow-up, but the number of eggs per gram was lower than the control group. The more interesting observation was that in the treated group none of the children developed hepatosplenic form, but in the control group, 35 patients had developed this clinical form of the disease (Bina 1977). This study was confirmed in different areas in Brazil, and was taken as a definitive study for the recommendation for the use of chemotherapy to prevent development of hepatosplenic form of the disease in endemic areas.…”

Evolution of schistosomiasis in an hyperendemic area of the Minas Gerais state: two cross-sectional studies

“…Nevertheless the inclusion of the negative patients in the cross-sectional study done in 1981 did not alter the differences in the rates of splenomegaly between the central zones and the surroundings of Comercinho 4 . KLOETZEL 11 and BINA 3 found that specific treatment might decrease the incidence of splenomegaly in schistosomiasis endemic areas. In the present investigation, the rate of children which had been treated was small (0% in 1974 and 1.5% in 1981) and did not differ between zones 1-2 and 3-4 (Table III).…”