Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms

Colley, Daniel G.; Parra, J. C.; Montesano, M. Angela; Lima, Maria Regina D’Império; Nascimento, Evaldo; Doughty, Barbara L.; Góes, Alfredo M.; Gazzinelli, Giovanni

doi:10.1590/s0074-02761987000800017

Cited by 5 publications

(2 citation statements)

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“…In this system, the appropriate T cells proliferate in response to immunoaffinity-purified or monoclonal (20,21) antibodies, against Schistosoma mansoni-soluble egg antigens (SEA)' or T. cruzi epimastigote antigens (EPI) (15,17,18). PBMC from individuals who have never had these infections are unresponsive to these antibodies, and neither patients with these infections nor uninfected subjects respond in culture to preparations of normal human immunoglobulin.…”

Section: Introductionmentioning

confidence: 99%

Idiotypic sensitization in utero of children born to mothers with schistosomiasis or Chagas' disease.

Elói-Santos

Novato-Silva²,

Maselli³

et al. 1989

J. Clin. Invest.

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Cord blood mononuclear cells (CBMC) of neonates born of mothers with Chagas' disease or schistosomiasis exhibited strong proliferative responses against idiotypes expressed on antibodies with specificity for Trypanosoma cruzi or Schistosoma mansoni antigens, respectively. These immunoaffinitypurified preparations were stimulatory if they were prepared from pools of patients' sera or from the mother's own serum, taken early during her pregnancy. These CBMC did not respond to normal immunoglobulin, and CBMC of neonates born of uninfected mothers did not respond to antibodies against either T. cruzi or S. mansoni, or normal immunoglobulin preparations.We propose that in utero exposure of a fetus to some idiotypes expressed on placentally transferred antibodies induces anti-Id T lymphocyte sensitization, which we detect as a proliferative response by CBMC exposed to immunoaffinity-purified antibodies expressing the relevant idiotypes. This is the first experimental evidence that children born of mothers with chronic infections undergo natural in utero idiotypic manipulations and are born possessing cellular anti-Id reactivity.

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Section: Introductionmentioning

confidence: 99%

Idiotypic sensitization in utero of children born to mothers with schistosomiasis or Chagas' disease.

Elói-Santos

Novato-Silva²,

Maselli³

et al. 1989

J. Clin. Invest.

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“…Worth noticing is that YRNA3 was negatively correlated in these processes, suggesting that the downregulation of YRNA3 may have a positive impact on tumor regression. YRNA3 in HPV(+) was mostly positively correlated with many processes; however, in one case it was negatively enriched in the JAK2 signaling pathway which plays a central role in cytokine and growth factor signaling [ 84 ]. Furthermore, enrichment in genes implicated in DNA repair processes, ribosome assembly processes, ribonucleoprotein complex biogenesis, spliceosomal SNRNP (small nuclear ribonucleoproteins) assembly and ribonucleoprotein complex subunit organization was observed in the case of YRNA4, which suggest its crucial role in forming a Ro60 ribonucleoprotein complex, one of the basic functions of YRNAs [ 1 , 2 , 12 , 13 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of YRNAs on HNSCC and HPV Infection

et al. 2023

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HPV infection is one of the most important risk factors for head and neck squamous cell carcinoma among younger patients. YRNAs are short non-coding RNAs involved in DNA replication. YRNAs have been found to be dysregulated in many cancers, including head and neck squamous cell carcinoma (HNSCC). In this study, we investigated the role of YRNAs in HPV-positive HNSCC using publicly available gene expression datasets from HNSCC tissue, where expression patterns of YRNAs in HPV(+) and HPV(−) HNSCC samples significantly differed. Additionally, HNSCC cell lines were treated with YRNA1-overexpressing plasmid and RNA derived from these cell lines was used to perform a NGS analysis. Additionally, a deconvolution analysis was performed to determine YRNA1’s impact on immune cells. YRNA expression levels varied according to cancer pathological and clinical stages, and correlated with more aggressive subtypes. YRNAs were mostly associated with more advanced cancer stages in the HPV(+) group, and YRNA3 and YRNA1 expression levels were found to be correlated with more advanced clinical stages despite HPV infection status, showing that they may function as potential biomarkers of more advanced stages of the disease. YRNA5 was associated with less-advanced cancer stages in the HPV(−) group. Overall survival and progression-free survival analyses showed opposite results between the HPV groups. The expression of YRNAs, especially YRNA1, correlated with a vast number of proteins and cellular processes associated with viral infections and immunologic responses to viruses. HNSCC-derived cell lines overexpressing YRNA1 were then used to determine the correlation of YRNA1 and the expression of genes associated with HPV infections. Taken together, our results highlight the potential of YRNAs as possible HNSCC biomarkers and new molecular targets.

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Cytokine secretion profile associated with periportal fibrosis in S. mansoni-infected Egyptian patients

Talaat¹,

El-Bassiouny

Osman

et al. 2007

Parasitol Res

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Periportal fibrosis (PPF) is a major pathological consequence of S. mansoni infection. Ultrasonography is a well-established tool for diagnosis and grading of schistosomiasis-related pathology. This work is performed to study the effect of schistosomiasis mansoni infection on the cytokine secretion profile in S. mansoni-infected patients at various grades of fibrosis, as determined by ultrasonography using Cairo Working Group classification. The levels of IL-2, IL-4, IL5, IL-10, IFN-gamma, and TNF-alpha were measured in the absence of in vitro antigen stimulation and after stimulation with worm and egg antigens. Simple intestinal (INT) patients are characterized by strong proliferation to worm antigen and high levels of IL-10 and TNF-alpha compared to patients at various grades of infection. GradeII (GdII)-infected patients are characterized by higher IL-5 production than are patients with other clinical forms of the disease. Sharp reduction of almost all cytokines in response to both worm and egg antigens was detected in GdIII-infected patients. These results stressed the role of both IL-10 and TNF-alpha in the early stages of hepatic fibrosis, while IL-5 could be employed as a potential predictive marker for advanced stages. In conclusion, PPF is associated with cytokine production profiles that vary with the magnitude of the fibrosis.

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Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms

Cited by 5 publications

References 0 publications

Idiotypic sensitization in utero of children born to mothers with schistosomiasis or Chagas' disease.

Idiotypic sensitization in utero of children born to mothers with schistosomiasis or Chagas' disease.

The Impact of YRNAs on HNSCC and HPV Infection

Cytokine secretion profile associated with periportal fibrosis in S. mansoni-infected Egyptian patients

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