Morbidity of Chagas' heart disease

Prata, Áluízio; Macêdo, Vanize

doi:10.1590/s0074-02761984000500018

Cited by 18 publications

(15 citation statements)

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“…This suggests, in accordance with population studies, that infected individuals become disabled for work earlier than the general population. They also presented a similar age distribution from that of infected individuals observed in crosssectional studies in rural areas where clinical manifestation are observed more frequently around the fourth and fifth decades of life 4,13 . In Goiás, the labour market is formed mainly by men, but both sexes have approximately equal demand for sickness benefits.…”

Section: Discussionsupporting

confidence: 71%

“…O esforço físico ocupacional estava associado a um risco relativo de 2,3 (LC95% l,5-4,6) e 1,8 (LC95% 1,2-3,5) comparando-se, respectivamente, atividades físicas ''pesada" e "moderada" em relação a atividades ocupacionais "leves". Comparando-se a amostra inicial de soropositivos e soronegativos (controles), foi estimado um risco relativo associado à cardiopatia de 8,5 (LC95% 4,[9][10][11][12][13][14]8). Riscos relativos de 37,1 (8,8 -155,6) e 4,4 (2,1 -9,1) foram obtidos para o bloqueio de ramo direito e hemibloqueio anterior esquerdo, respectivamente.…”

Section: Introductionunclassified

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Chagas' disease and social security: a case-control study in an urban area, Goiás, Brazil

Zicker

1988

Rev. Saúde Pública

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' disease and social security. A case-control study in an urban area, Goiás, Brazil. Rev. Saúde públ., S. Paulo, 22:281-7, 1988. ABSTRACT:One hundred and twenty subjects with Chagas' cardiopathy and 120 non-infected subjects were randomly selected from first time claimants of sickness benefits in the National Institute of Social Security (INPS) in Goiás. Cases of Chagas' cardiopathy were defined based on serological test, history of residence in an endemic area and, clinical and/or electrocardiogram (ECG) alterations suggestive of Chagas' cardiomyopathy. Controls were defined as subjects with at least two negative serological tests. Case and controls were compared in the analysis for age, sex, place of birth, migration history, socio-economic level, occupation, physical exertion at work, age at affiliation and years of contribution to the social security scheme, clinical course of their disease and ECG abnormalities. Chagas' disease patients were younger than other subjects and predominantly of rural origin. Noninfected subjects presented a better socio-economic level, were performing more skilled activities and had less changes of job than cases. No important difference was observed in relation to age at affiliation to INPS. About 60% of cases have claimed for benefits within the first four years of contribution while among controls this proportion was 38.5%. Cases were involved, proportionally more than controls, in "heavy" activities. A risk of 2.3 (95%CL 1.5 -4.6) and 1.8 (95%CL 1.2-3.5) was obtained comparing respectively "heavy" and "moderate" physical activity against "light". A relative risk of 8.5 (95%CL 4.9 -14.8) associated with the presence of cardiopathy was estimated comparing the initial sample of seropositive subjects and controls. A high relative risk was observed in relation to right bundle branch block (RR = 37.1 95%CL = 8.8 -155.6) and left anterior hemiblock (RR = 4.4, 95%CL = 2.1 -9.1).

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Section: Discussionsupporting

confidence: 71%

Section: Introductionunclassified

Chagas' disease and social security: a case-control study in an urban area, Goiás, Brazil

Zicker

1988

Rev. Saúde Pública

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“…No other complementary examinations in addition to those previously listed, are required to define ICF. The expression indetermined chronic form was first used by Carlos Chagas and stablished by its use (195) (196) (197) (198) . The reference of this term, mainly in the context of scientific research, was consolidated by Brazilian researchers in 1984 (20) (142) (188) (199) .…”

Section: Diagnostic Criteriamentioning

confidence: 99%

2 nd Brazilian Consensus on Chagas Disease, 2015

Dias

Ramos

Gontijo

et al. 2016

Rev. Soc. Bras. Med. Trop.

307

677

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“…Despite efforts by governments and overall improvement in living conditions in Central and South America, millions of people are exposed to the disease-causing parasites annually, and it remains a leading cause of cardiac and pulmonary morbidity and mortality, adding greatly to the cost of health care (19). Through the use of residual insecticides and improvement in housing standards there is a hope for eradication of this disease from human populations.…”

Section: Discussionmentioning

confidence: 99%

Prevention of insect-borne disease: An approach using transgenic symbiotic bacteria

Durvasula

Gumbs²,

Panackal³

et al. 1997

Proc. Natl. Acad. Sci. U.S.A.

284

237

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Expression of molecules with antiparasitic activity by genetically transformed symbiotic bacteria of disease-transmitting insects may serve as a powerful approach to control certain arthropod-borne diseases. The endosymbiont of the Chagas disease vector, Rhodnius prolixus, has been transformed to express cecropin A, a peptide lethal to the parasite, Trypanosoma cruzi. In insects carrying the transformed bacteria, cecropin A expression results in elimination or reduction in number of T. cruzi. A method has been devised to spread the transgenic bacteria to populations of R. prolixus, in a manner that mimics their natural coprophagous route of symbiont acquisition.

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Morbidity of Chagas' heart disease

Cited by 18 publications

References 0 publications

Chagas' disease and social security: a case-control study in an urban area, Goiás, Brazil

Chagas' disease and social security: a case-control study in an urban area, Goiás, Brazil

2 nd Brazilian Consensus on Chagas Disease, 2015

Prevention of insect-borne disease: An approach using transgenic symbiotic bacteria

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