Brucelose humana no Brasil: contribuição para o estudo da casuística nacional

Pacheco, G Vaca; Mello, Milton Thiago de

doi:10.1590/s0074-02761950000100015

Cited by 7 publications

(5 citation statements)

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“…Even though respiratory involvement occurs mainly through inhalation [16], two of our patients (6 and 7) showed this form of the disease. Pulmonary micronodes seen in patient 9 were attributed to concurrent tuberculosis, this association between brucellosis and tuberculosis having been reported in only a few instances [23].…”

Section: Discussionmentioning

confidence: 81%

Urban outbreak of a Brucella melitensis infection in an Argentine family: Clinical and diagnostic aspects

Wallach¹

1994

FEMS Immunology and Medical Microbiology

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An outbreak of Brucella melitensis in a family was studied. From the fourteen family members who ate unpasteurized goat cheese nine became ill. Patients included four females and five males of 8 to 75 years old. In seven of the patients the diagnosis was confirmed by positive blood culture for B. melitensis biovar 1. All the patients were analyzed by standard tube agglutination (STA) and standard tube agglutination with 2-mercaptoethanol (STA-2ME) tests at the time of diagnosis. In six of the patients, ELISA assays were used to assess the humoral immune anti-protein and anti-lipopolysaccharide (LPS) responses. Anti-LPS IgG antibodies were detected in all of the patients. Anti-proteins IgG antibodies were present at significant levels in all the studied patients including the STA-2ME negative ones.

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Section: Discussionmentioning

confidence: 81%

Urban outbreak of a Brucella melitensis infection in an Argentine family: Clinical and diagnostic aspects

Wallach¹

1994

FEMS Immunology and Medical Microbiology

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“…Spinola & Costa [26] in Salvador, Bahia, have studied human brucellosis under the serological, occupational and clinic perspective in 128 cold storage plant workers and reported a prevalence of 10.6% in the test of fast and slow seroagglutination. In general, it is considered that individuals working in slaughterhouses and cold storage plants, mainly those involved in evisceration, become more easily infected [27], since the gravid uterus, the fetal membranes and annexes are the places where Brucella sp. are most often lodged [16] and thus manipulation of these tissues can favor the infection in humans.…”

Section: Resultsmentioning

confidence: 99%

Epidemiological aspects of an infection by Brucella abortus in risk occupational groups in the microregion of Araguaína, Tocantins

et al. 2008

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The aim of this paper was to study some epidemiological aspects of the infection by Brucella abortus in risk occupational groups in the microregion of Araguaína, Tocantins. For antibody research, 645 serum samples were analyzed by the complement fixation test (CF). A 4.0% frequency was found (26/645) in patients' serum and among those 4.1% (23/551) were slaughterhouses employees and 8.1% (3/37) rural workers. Of the total positive samples, three (2.0%) were women and 23 (4.7%) men; ten (2.9%) were between the ages of 18 and 30, six (3.4%) between 31 and 40, and nine (8.0%) were above 41 years of age. Risk factors for brucellosis in the study groups were age, background (OR = 2.45; CI 95% = 0.98 to 6.10) and previous work conducted with production animals (OR 2.36; CI 95% = 0.95 to 6.02). It was concluded that the infection by Brucella abortus is found in some risk occupational groups in the microregion of Araguaína, Tocantins, and control and prophylactic measures must be implemented emphasizing risk factors identified in the study.

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“…In Brazil, the first HB case was reported in Rio de Janeiro in 1934 [ 18 ]. Since then, the number of reported cases has increased.…”

Section: Discussionmentioning

confidence: 99%

“…Since the first case that was published in Brazil in 1934 [ 18 ], HB has been reported throughout the country, but it is generally restricted to workers of slaughterhouses, consumers of unpasteurized milk from areas of high incidence of bovine brucellosis [ 19 ], and agricultural workers [ 20 ]. In this study, we described the largest HB outbreak in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Outbreak of human brucellosis in Southern Brazil and historical review of data from 2009 to 2018

et al. 2018

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BackgroundHuman brucellosis (HB) is a bacterial zoonosis that is more frequent in low income and middle-income countries; it is sometimes associated with outbreaks. The aim of this study was to describe the largest outbreak of HB in Brazil.MethodsA retrospective cohort study of patients suspected of having contracted HB in the state of Paraná, Southern Brazil from January 2009 to January 2017. Following an outbreak of 51 cases of HB in a slaughterhouse at Paiçandu in 2014, HB was defined as an obligatory reportable disease in the State. Diagnostic tests for HB included serum agglutination, ELISA (IgG or IgM) and polymerase chain reaction (PCR). Clinical, laboratorial and epidemiological data were analyzed. A P value of 0.05 was considered statistically significant.ResultsOut of a total of 3,941 patients, 754 presented with a positive test result for HB. After 2014, there was a significant increase in the number of cases, exceeding 100 cases per trimester. In the beginning of 2015, the workgroup of HB started several actions for prevention and treatment, and the number of cases progressively diminished to fewer than 20 cases per trimester. Of 191 reported cases, an occupational risk was found in 84.7%; most cases occurred in farmers (60.0%), veterinarians (17.6%) and slaughterhouse workers (14.7%). Manipulation of animals and unpasteurized milk consumption were associated with positive Brucella IgM ELISA with an odds ratio (OR) of 1.42 (1.09–1.84) and 1.48 (1.01–2.15), respectively.ConclusionsHB outbreaks can occur in low to middle-income countries and are associated with slaughterhouse work, handling of unpasteurized milk and animal manipulation. Intensive programs for control of HB are important to reduce the number of cases.

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Brucelose humana no Brasil: contribuição para o estudo da casuística nacional

Cited by 7 publications

References 0 publications

Urban outbreak of a Brucella melitensis infection in an Argentine family: Clinical and diagnostic aspects

Urban outbreak of a Brucella melitensis infection in an Argentine family: Clinical and diagnostic aspects

Epidemiological aspects of an infection by Brucella abortus in risk occupational groups in the microregion of Araguaína, Tocantins

Outbreak of human brucellosis in Southern Brazil and historical review of data from 2009 to 2018

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