A dysenteria bacillar na cidade da Bahia

Pacheco, G

doi:10.1590/s0074-02761925000100002

Cited by 11 publications

(6 citation statements)

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“… 79 Numerous data on the influence of colloidal gold on nonspecific immune response are given in one of the best early reviews. 80 In particular, it was noted that at 2 h after an intravenous injection of 5 mL of colloidal gold into rabbits, there was a sizable increase in total leucocytes in 1 mL of blood (from 10 000 to 19 800) against a slight decline in mononuclear cells (from 5200 to 4900) and a considerable increase in polynuclear cells (from 4700 to 14 900). 81 On injection of other colloidal metals, no such phenomena were observed.…”

Section: Production Of Antibodies By Using Gold Nanoparticlesmentioning

confidence: 99%

Immunological properties of gold nanoparticles

2017

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Section: Production Of Antibodies By Using Gold Nanoparticlesmentioning

confidence: 99%

Immunological properties of gold nanoparticles

2017

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“…It should be said that issues related to the toxicity of metallic gold were raised earlier as well. [118][119][120] In those early articles, it was noted that injection of metallic gold into laboratory animals may lead to inflammatory responses, accumulation of gold in the reticular cells of lymphoid tissue, and activation of cellular and humoral immunity. In his excellent review of pioneering works, Pacheco 118 presented many data on the effect of CG on nonspecific immune responses.…”

Section: Toxicology Studies 31 Preliminary Remarksmentioning

confidence: 99%

“…[118][119][120] In those early articles, it was noted that injection of metallic gold into laboratory animals may lead to inflammatory responses, accumulation of gold in the reticular cells of lymphoid tissue, and activation of cellular and humoral immunity. In his excellent review of pioneering works, Pacheco 118 presented many data on the effect of CG on nonspecific immune responses. Specifically, he noted that at 2 h after rabbits had been injected intravenously with 5 ml of GNPs, there was a considerable increase in the total number of leukocytes in 1 ml of blood (from 9900 to 19 800) against the background of a slight decrease in mononuclear forms (from 5200 to 4900) and a large increase in polynuclear forms (from 4700 to 14 900).…”

Section: Toxicology Studies 31 Preliminary Remarksmentioning

confidence: 99%

Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies

2011

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Recent advances in wet chemical synthesis and biomolecular functionalization of gold nanoparticles have led to a dramatic expansion of their potential biomedical applications, including biosensorics, bioimaging, photothermal therapy, and targeted drug delivery. As the range of gold nanoparticle types and their applications continues to increase, human safety concerns are gaining attention, which makes it necessary to better understand the potential toxicity hazards of these novel materials. Whereas about 80 reports on the in vivo biodistribution and in vitro cell toxicity of gold nanoparticles are available in the literature, there is lack of correlation between both fields and there is no clear understanding of intrinsic nanoparticle effects. At present, the major obstacle is the significant discrepancy in experimental conditions under which biodistribution and toxicity effects have been evaluated. This critical review presents a detailed analysis of data on the in vitro and in vivo biodistribution and toxicity of most popular gold nanoparticles, including atomic clusters and colloidal particles of diameters from 1 to 200 nm, gold nanoshells, nanorods, and nanowires. Emphasis is placed on the systematization of data over particle types and parameters, particle surface functionalization, animal and cell models, organs examined, doses applied, the type of particle administration and the time of examination, assays for evaluating gold particle toxicity, and methods for determining the gold concentration in organs and distribution of particles over cells. On the basis of a critical analysis of data, we arrive at some general conclusions on key nanoparticle parameters, methods of particle surface modification, and doses administered that determine the type and kinetics of biodistribution and toxicity at cellular and organismal levels (197 references).

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“…79 Numerous data on the inuence of colloidal gold on nonspecic immune response are given in one of the best early reviews. 80 In particular, it was noted that at 2 h aer an intravenous injection of 5 mL of colloidal gold into rabbits, there was a sizable increase in total leucocytes in 1 mL of blood (from 10 000 to 19 800) against a slight decline in mononuclear cells (from 5200 to 4900) and a considerable increase in polynuclear cells (from 4700 to 14 900). 81 On injection of other colloidal metals, no such phenomena were observed.…”

Section: Production Of Antibodies By Using Gold Nanoparticlesmentioning

confidence: 99%

Immunological Properties of Gold Nanoparticles

Дыкман¹,

Khlebtsov²

2017

Gold Nanoparticles in Biomedical Applications

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In the past decade, gold nanoparticles have attracted strong interest from the nanobiotechnological community owing to the significant progress made in robust and easy-to-make synthesis technologies, in surface functionalization, and in promising biomedical applications. These include bioimaging, gene diagnostics, analytical sensing, photothermal treatment of tumors, and targeted delivery of various biomolecular and chemical cargos. For the last-named application, gold nanoparticles should be properly fabricated to deliver the cargo into the targeted cells through effective endocytosis. In this review, we discuss recent progress in understanding the selective penetration of gold nanoparticles into immune cells. The interaction of gold nanoparticles with immune cell receptors is discussed. As distinct from other published reviews, we present a summary of the immunological properties of gold nanoparticles. This review also summarizes what is known about the application of gold nanoparticles as an antigen carrier and adjuvant in immunization for the preparation of antibodies in vivo. For each of the above topics, the basic principles, recent advances, and current challenges are discussed. Thus, this review presents a detailed analysis of data on interaction of gold nanoparticles with immune cells.Emphasis is placed on the systematization of data over production of antibodies by using gold nanoparticles and adjuvant properties of gold nanoparticles. Specifically, we start our discussion with current data on interaction of various gold nanoparticles with immune cells. The next section describes existing technologies to improve production of antibodies in vivo by using gold nanoparticles conjugated with specific ligands. Finally, we describe what is known about adjuvant properties of bare gold or functionalized nanoparticles. In the Conclusion section, we present a short summary of reported data and some challenges and perspectives.

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A dysenteria bacillar na cidade da Bahia

Cited by 11 publications

References 0 publications

Immunological properties of gold nanoparticles

Immunological properties of gold nanoparticles

Biodistribution and toxicity of engineered gold nanoparticles: a review of in vitro and in vivo studies

Immunological Properties of Gold Nanoparticles

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