Traços de Oswaldo Cruz

Chagas, Carlos Ribeiro Justiniano das

doi:10.1590/s0074-02761922000200002

Cited by 14 publications

(17 citation statements)

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“…Dysautonomia in CHD was reported as early as 1922 when Chagas and Vilella described evidence of autonomic degeneration in T. cruzi-infected patients [18]. By the 1950s several studies had been published detailing severe cardiac neuronal damage in Chagas patients leading Köberle to propose the neurogenic hypothesis of Chagas cardiomyopathy [19].…”

Section: Primary Neuronal Damagementioning

confidence: 99%

Chagas Heart Disease Pathogenesis: One Mechanism or Many?

Bonney

Engman²

2008

CMM

150

144

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Chagas heart disease (CHD), caused by the protozoan parasite Trypanosoma cruzi, is the leading cause of infectious myocarditis in the world. The etiology of CHD is unclear and multiple mechanisms have been proposed to explain the pathogenesis of the disease. This review describes the proposed mechanisms of CHD pathogenesis and evaluates the historical significance and evidence supporting each. Although the majority of CHD-related pathologies are currently attributed to parasite persistence in the myocardium and autoimmunity, there is strong evidence that CHD develops as a result of additive and even synergistic effects of several distinct mechanisms rather than one factor.

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Section: Primary Neuronal Damagementioning

confidence: 99%

Chagas Heart Disease Pathogenesis: One Mechanism or Many?

Bonney

Engman²

2008

CMM

150

144

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“…Chronic Chagas’ heart disease (cChHD) is the most frequent and severe clinical consequence of infection with Trypanosoma cruzi [1]. The mechanisms responsible for the cardiomyopathy are not clearly understood, but the occurrence of chronic myocardial injury in the near absence of parasites suggests an autoimmune mechanism [2].…”

Section: Introductionmentioning

confidence: 99%

Correlation between conformation and antibody binding: NMR structure of cross‐reactive peptides from T. cruzi, human and L. braziliensis

et al. 2004

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The structure of peptides corresponding to the C-terminal residues from Trypanosoma cruzi (R13), human (H13) and Leishmania braziliensis (A13) ribosomal proteins were determined using nuclear magnetic resonance. Although there is only one amino acid di¡erence between them, the peptides present distinct structures in solution: R13 adopts a random coil conformation while H13 and A13 form a bend. Interaction of these peptides with polyclonal antibodies from chronic Chagas' disease patients and a monoclonal antibody raised against T. cruzi ribosomal P2L L protein was probed by transferred NOE. The results show that the £exibility of R13 is fundamental for the binding to the antibody. ß 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

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“…The protozoan parasite Trypanosoma cruzi is the etiological agent of American Trypanosomiasis or Chagas' Disease [1]. The transformation of epimastigotes into metacyclic trypomastigotes, the natural infective forms, is a crucial step in T. cruzi life cycle [2].…”

Section: Introductionmentioning

confidence: 99%

Changes in fatty acid composition associated with differentiation of Trypanosoma cruzi

Esteves¹,

Gonzales-Perdomo

Alviano³

et al. 1989

FEMS Microbiology Letters

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The fatty acid composition during the transformation of Trypanosoma cruzi epimastigotes into metacyclic trypomastigotes (metacyclogenesis) was analysed by gas‐liquid chromatography and mass spectrometry. Significant qualitative and quantitative changes in the fatty acid composition occurred during incubation of epimastigotes derived from LIT medium in the triatomine artificial urine (TAU). Metacyclogenesis was also followed by alterations in the fatty acid pattern but these were considerably less pronounced when compared to the pattern obtained for TAU‐incubated epimastigotes. These results suggest that changes in the lipid composition precede the morphological transformation of epimastigotes into metacyclic trypomastigotes.

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Traços de Oswaldo Cruz

Cited by 14 publications

References 0 publications

Chagas Heart Disease Pathogenesis: One Mechanism or Many?

Chagas Heart Disease Pathogenesis: One Mechanism or Many?

Correlation between conformation and antibody binding: NMR structure of cross‐reactive peptides from T. cruzi, human and L. braziliensis

Changes in fatty acid composition associated with differentiation of Trypanosoma cruzi

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