Felipressina aumenta pressão arterial durante procedimento odontológico em pacientes hipertensos

Bronzo, Ana Lúcia Aparecida; Cardoso, Crivaldo Gomes; Ortega, Kátia Coelho; Mion, Décio

doi:10.1590/s0066-782x2012005000062

Cited by 21 publications

(12 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although felypressin has not systemic effects of epinephrine; it has some cardiovascular effects (Bronzo, Cardoso, Ortega, & Mion, 2012). Prilocaine has also been found to have a number of side effects including methemoglobinemia (Doko et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Comparative Assessment of the Effects of Three Local Anesthetics: Lidocaine, Prilocaine, and Mepivacaine on Blood Pressure Changes in Patients with Controlled Hypertension

Hashemi¹,

Ladez²,

Moghadam³

2016

GJHS

View full text Add to dashboard Cite

Background: Given large number of patients with hypertension attending dental clinics and the profound effects of local anesthetics containing vasoconstrictors, this study aimed to compare the effects of lidocaine 2% + epinephrine, prilocaine 3% + felypressin0.03, and mepivacaine 3% on blood pressure changes. Methods:The current study was carried out from May 2014 to February 2015.Patients with controlled hypertension (systolic blood pressure<159.94 mmHg before the injection) who attended Zahedan dental school (Zahedan , Iran) for the extraction of a mandibular tooth were selected and randomly allocated to three groups of 20. Groups 1-3 received lidocaine 2% + epinephrine, prilocaine 3% + felypressin 0.03 units, and mepivacaine3%, respectively. Patients were only included if they were injected with a maximum of two 1.8 ml cartridges (3.6 ml) for tooth extraction (maximum epinephrine dose of 0.04 mg was maintained in systemic patients).The collected data were analyzed using the analysis of variance (ANOVA) in SPSS 19.0. (SPSS Inc., Chicago, IL, USA)Results: No significant differences were observed between the systolic and diastolic blood pressure of the three groups. The three evaluated local anesthetic solutions had similar effects in patients with controlled hypertension. Conclusion:While no significant changes in blood pressure were observed in three groups, all dental procedures on the mentioned group of patients have to be performed under careful monitoring and aspiration. Moreover, the maximum epinephrine dose (0.04mg) should never be exceeded in these patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparative Assessment of the Effects of Three Local Anesthetics: Lidocaine, Prilocaine, and Mepivacaine on Blood Pressure Changes in Patients with Controlled Hypertension

Hashemi¹,

Ladez²,

Moghadam³

2016

GJHS

View full text Add to dashboard Cite

show abstract

“…From the 28 preselected papers, 18 were excluded (online supplemental appendix 3) and 10 met eligibility criteria. [29][30][31][32][33][34][35][36][37][38] Six studies 29 31 32 34 35 38 were included in the meta-analysis (figure 1).…”

Section: Literature Search Resultsmentioning

confidence: 99%

Local anaesthetics combined with vasoconstrictors in patients with cardiovascular disease undergoing dental procedures: systematic review and meta-analysis

et al. 2021

View full text Add to dashboard Cite

ObjectivesThere is a lack of evidence about the use of local anaesthetics (LAs) in patients with cardiovascular diseases (CVD) in dental procedures. Thus, this study evaluated the safety of using LA with vasoconstrictor to determine the risk of cardiovascular events in patients with CVD.DesignSystematic review and meta-analysis.MethodsWe have searched in Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (via Ovid), EMBASE (via Ovid), Healthstar (via Ovid), CINAHL, Web of Science and ClinicalTrials.gov for randomised controlled trials (RCTs) up to January 2020. We have included RCTs involving adults with CVD within two groups: intervention group with LA with vasoconstrictor and control group with LA without vasoconstrictor. The primary outcomes assessed were death, mortality by a specific cause, stroke, acute myocardial infarction, hospitalisation, pain, bleeding and arrhythmias. The secondary outcomes were ST segment depression, anxiety, adverse effects and changes in haemodynamic parameters. The data were pooled using random effects meta-analyses and the confidence in the estimates was verified using the Grading of Recommendations Assessment, Development and Evaluation (GRADE).ResultsTen RCTs (n=478 participants) were included. Most of them had a high risk of bias. There were more cases of pain and bleeding in groups without vasoconstrictor. Meta-analysis demonstrated a decrease in the systolic blood pressure with the use of LA with vasoconstrictor (standard mean difference −0.95, 95% CI −1.35 to −0.55) after procedure. Overall, for the other outcomes assessed there was no statistical difference. The quality of evidence was considered low according to the GRADE profile.ConclusionsThe results suggest that the use of LA with vasoconstrictors (epinephrine in low doses) is safe in patients with some types of CVD. However, the low quality of evidence demonstrated that literature needs further studies in order to confirm these results.Protocol registrationPROSPERO (CRD42016045421).

show abstract

“…However, their findings were questionable, particularly if study design or sample size was inappropriate. [ 16 17 18 19 ] Our aim is to assess the depth of local anesthesia (LA) in healthy patients when buccal infiltration of 2% lidocaine with adrenaline (1:100,000) and 3% prilocaine with felypressin (0.03 IU per ml) were administrated. The null hypothesis is the buccal and palatal infiltrations of lidocaine and prilocaine injections are equally effective in securing teeth anesthesia in maxillary.…”

Section: Introductionmentioning

confidence: 99%

2% lidocaine versus 3% prilocaine for oral and maxillofacial surgery

et al. 2018

View full text Add to dashboard Cite

Felipressina aumenta pressão arterial durante procedimento odontológico em pacientes hipertensos

Cited by 21 publications

References 19 publications

Comparative Assessment of the Effects of Three Local Anesthetics: Lidocaine, Prilocaine, and Mepivacaine on Blood Pressure Changes in Patients with Controlled Hypertension

Comparative Assessment of the Effects of Three Local Anesthetics: Lidocaine, Prilocaine, and Mepivacaine on Blood Pressure Changes in Patients with Controlled Hypertension

Local anaesthetics combined with vasoconstrictors in patients with cardiovascular disease undergoing dental procedures: systematic review and meta-analysis

2% lidocaine versus 3% prilocaine for oral and maxillofacial surgery

Contact Info

Product

Resources

About