Polimorfismos beta1-adrenérgico associados com Fibrilação Atrial na Insuficiência Cardíaca Sistólica

Nascimento, Bruno Costa do; Pereira, Sabrina Bernárdez; Ribeiro, Georgina Severo; Mesquita, Evandro Tinoco

doi:10.1590/s0066-782x2012005000037

Cited by 9 publications

(3 citation statements)

References 25 publications

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“…Numerous previous clinical studies have confirmed that long-term treatment with β 1-AR blocker could significantly improve cardiac function; therefore, they reduce the total mortality and morbidity in patients with heart failure [36–38]. Our present study is consistent with the previous study which demonstrated that treatment with β -AR blocker could improve ventricular function and reduce cardiomyocyte apoptosis in myopathic turkeys [39].…”

Section: Discussionsupporting

confidence: 92%

Effects ofβ-Adrenoceptor Subtypes on Cardiac Function in Myocardial Infarction Rats Exposed to Fine Particulate Matter (PM_2.5)

Gao

Lin

et al. 2014

BioMed Research International

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The pathophysiological mechanisms of heart failure (HF) stems were mainly from longstanding overactivation of the sympathetic nervous system and renin-angiotensin-aldosterone system. Recent studies highlighted the potential benefits of β1-adrenoceptor (β1-AR) blocker combined with β2-adrenergic receptor (β2-AR) agonist in patients with HF. Long-term exposure to fine particulate air pollution, such as particulate matter ≤ 2.5 μm in diameter (PM2.5), has been found associated with acute myocardial infarction (AMI) which is the most common cause of congestive HF. In this study, we have investigated the effect of combined metoprolol and terbutaline on cardiac function in a rat model of AMI exposed to PM2.5. Our results demonstrated that short-term exposure to PM2.5 contributes to aggravate cardiac function in rats with myocardial infarction. The combined use of β1-AR blocker and β2-AR agonist is superior to β1-AR blocker alone for the treatment of AMI rats exposed to PM2.5. The combination of β1-AR blocker and β2-AR agonist may decrease the mortality of patients with myocardial infarction who have been exposed to PM2.5.

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Section: Discussionsupporting

confidence: 92%

Effects ofβ-Adrenoceptor Subtypes on Cardiac Function in Myocardial Infarction Rats Exposed to Fine Particulate Matter (PM_2.5)

Gao

Lin

et al. 2014

BioMed Research International

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“…Some studies reported that AA genotype (Ser49) carriers of polymorphism Ser49Gly have a lower heart rate and lower frequency of rhythm disturbances and therefore lower mortality [19]. However, in Russian study, in which the prevalence of primary and secondary AF in carriers of different Ser49Gly genotypes was examined, the opposite data were obtained.…”

Section: Resultsmentioning

confidence: 99%

“…Additionally, Gly49Gly homozygotes were reported to have lower basal heart rate (HR) and arrhythmogenesis [13–17]. Several authors considered heterozygous genotype Ser49Gly to be one of the genetic predictors of initial or secondary atrial fibrillation (AF) [18, 19]. However, no relationship between Ser49Gly genotype and family history of AF was found [20].…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms ofβ1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis

Бабенко

Grineva

Savitskaja

et al. 2014

BioMed Research International

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Human cardiac β1-AR perform a crucial role in mediating the cardiostimulating effects of norepinephrine. Gly389Arg and Ser49Gly polymorphisms of β1-adrenoreceptors (β1-AR) can influence the cardiovascular prognosis. However, the possible effect of Gly389Arg and Ser49Gly polymorphisms on heart function in thyrotoxicosis has not been studied. We investigated the possible link between Gly389Arg and Ser49Gly polymorphisms and echocardiography parameters in 165 normotensive patients with a thyrotoxicosis without any cardiovascular disorders. Echo-CG was performed according to standard protocol before and during the thyreostatic treatment. Our data demonstrate that both Gly389Arg and Ser49Gly polymorphisms have very moderate influence on the risk of left ventricular hypertrophy and atrial fibrillation with no statistically significant effects on cardiac function and the development of cardiovascular complications.

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Atrial Fibrillation in Patients with Heart Failure: Current State and Future Directions

Mene-Afejuku

López

Akinlonu

et al. 2018

Am J Cardiovasc Drugs

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Heart failure affects nearly 26 million people worldwide. Patients with heart failure are frequently affected with atrial fibrillation, and the interrelation between these pathologies is complex. Atrial fibrillation shares the same risk factors as heart failure. Moreover, it is associated with a higher-risk baseline clinical status and higher mortality rates in patients with heart failure. The mechanisms by which atrial fibrillation occurs in a failing heart are incompletely understood, but animal studies suggest they differ from those that occur in a healthy heart. Data suggest that heart failure-induced atrial fibrosis and atrial ionic remodeling are the underlying abnormalities that facilitate atrial fibrillation. Therapeutic considerations for atrial fibrillation in patients with heart failure include risk factor modification and guideline-directed medical therapy, anticoagulation, rate control, and rhythm control. As recommended for atrial fibrillation in the non-failing heart, anticoagulation in patients with heart failure should be guided by a careful estimation of the risk of embolic events versus the risk of hemorrhagic episodes. The decision whether to target a rate-control or rhythm-control strategy is an evolving aspect of management. Currently, both approaches are good medical practice, but recent data suggest that rhythm control, particularly when achieved through catheter ablation, is associated with improved outcomes. A promising field of research is the application of neurohormonal modulation to prevent the creation of the "structural substrate" for atrial fibrillation in the failing heart.

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Polimorfismos beta1-adrenérgico associados com Fibrilação Atrial na Insuficiência Cardíaca Sistólica

Abstract: Background: The sympathetic nervous system is of great importance in the pathogenesis of atrial fibrillation in systolic heart failure. The identification of polymorphisms in the beta1-adrenergic receptor gene (ADBR1) represents an important step in understanding this pathogenesis.

Cited by 9 publications

References 25 publications

Effects ofβ-Adrenoceptor Subtypes on Cardiac Function in Myocardial Infarction Rats Exposed to Fine Particulate Matter (PM_2.5)

Effects ofβ-Adrenoceptor Subtypes on Cardiac Function in Myocardial Infarction Rats Exposed to Fine Particulate Matter (PM_2.5)

Polymorphisms ofβ1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis

Atrial Fibrillation in Patients with Heart Failure: Current State and Future Directions

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Polimorfismos beta1-adrenérgico associados com Fibrilação Atrial na Insuficiência Cardíaca Sistólica

Abstract: Background: The sympathetic nervous system is of great importance in the pathogenesis of atrial fibrillation in systolic heart failure. The identification of polymorphisms in the beta1-adrenergic receptor gene (ADBR1) represents an important step in understanding this pathogenesis.

Cited by 9 publications

References 25 publications

Effects ofβ-Adrenoceptor Subtypes on Cardiac Function in Myocardial Infarction Rats Exposed to Fine Particulate Matter (PM2.5)

Effects ofβ-Adrenoceptor Subtypes on Cardiac Function in Myocardial Infarction Rats Exposed to Fine Particulate Matter (PM2.5)

Polymorphisms ofβ1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis

Atrial Fibrillation in Patients with Heart Failure: Current State and Future Directions

Contact Info

Product

Resources

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Effects ofβ-Adrenoceptor Subtypes on Cardiac Function in Myocardial Infarction Rats Exposed to Fine Particulate Matter (PM_2.5)

Effects ofβ-Adrenoceptor Subtypes on Cardiac Function in Myocardial Infarction Rats Exposed to Fine Particulate Matter (PM_2.5)