Escore de cálcio na avaliação da aterosclerose em pacientes com HIV/AIDS

Monteiro, Verônica Soares; Lacerda, Heloísa Ramos; Uellendahl, Marly; Chang, Tien Man; Albuquerque, Valéria Maria de; Zirpoli, Josefina Cláudia; Ximenes, Ricardo A. A.; Albuquerque, Maria de Fátima Militão de; Filho, Demócrito de Barros Miranda; Filho, Dário Sobral

doi:10.1590/s0066-782x2011005000094

Cited by 8 publications

(1 citation statement)

References 24 publications

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“…Considering that atherosclerotic Coronary Artery Disease (CAD) is an important cause of morbidity and mortality in the population of HIV-positive patients, its onset seems to be due to chronic viral infection and side effects of antiretroviral drugs, which together result in metabolic disturbances (glucose intolerance, diabetes mellitus, dyslipidemia, lipodystrophy) and endothelial damage [5][6][7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Associação dos biomarcadores com aterosclerose e risco para doença coronariana em portadores de HIV

Falcão¹,

Zirpoli²,

Albuquerque³

et al. 2012

Arq. Bras. Cardiol.

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Section: Introductionmentioning

confidence: 99%

Associação dos biomarcadores com aterosclerose e risco para doença coronariana em portadores de HIV

Falcão¹,

Zirpoli²,

Albuquerque³

et al. 2012

Arq. Bras. Cardiol.

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The challenge of cardiovascular diseases in HIV-positive patients: it’s time for redrawing the maps of cardiovascular risk?

Ceccarelli¹,

d’Ettorre²,

Vullo³

2012

International Journal of Clinical Practice

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Coronary Artery Calcification and Plaque Characteristics in People Living With HIV: A Systematic Review and Meta‐Analysis

Soares

Samara

Yuyun

et al. 2021

JAHA

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Background Studies have reported that people living with HIV have higher burden of subclinical cardiovascular disease, but the data are not adequately synthesized. We performed meta‐analyses of studies of coronary artery calcium and coronary plaque in people living with HIV. Methods and Results We performed systematic search in electronic databases, and data were abstracted in standardized forms. Study‐specific estimates were pooled using meta‐analysis. 43 reports representing 27 unique studies and involving 10 867 participants (6699 HIV positive, 4168 HIV negative, mean age 52 years, 86% men, 32% Black) were included. The HIV‐positive participants were younger (mean age 49 versus 57 years) and had lower Framingham Risk Score (mean score 6 versus 18) compared with the HIV‐negative participants. The pooled estimate of percentage with coronary artery calcium >0 was 45% (95% CI, 43%–47%) for HIV‐positive participants, and 52% (50%–53%) for HIV‐negative participants. This difference was no longer significant after adjusting for difference in Framingham Risk Score between the 2 groups. The odds ratio of coronary artery calcium progression for HIV‐positive versus ‐negative participants was 1.64 (95% CI, 0.91–2.37). The pooled estimate for prevalence of noncalcified plaque was 49% (95% CI, 47%–52%) versus 20% (95% CI, 17%–23%) for HIV‐positive versus HIV‐negative participants, respectively. Odds ratio for noncalcified plaque for HIV‐positive versus ‐negative participants was 1.23 (95% CI, 1.08–1.38). There was significant heterogeneity that was only partially explained by available study‐level characteristics. Conclusions People living with HIV have higher prevalence of noncalcified coronary plaques and similar prevalence of coronary artery calcium, compared with HIV‐negative individuals. Future studies on coronary artery calcium and plaque progression can further elucidate subclinical atherosclerosis in people living with HIV.

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Escore de cálcio na avaliação da aterosclerose em pacientes com HIV/AIDS

Abstract: Background: Antiretroviral therapy has dramatically increased life expectancy in patients with HIV/AIDS although atherosclerosis has been associated with long-standing therapy.

Cited by 8 publications

References 24 publications

Associação dos biomarcadores com aterosclerose e risco para doença coronariana em portadores de HIV

Associação dos biomarcadores com aterosclerose e risco para doença coronariana em portadores de HIV

The challenge of cardiovascular diseases in HIV-positive patients: it’s time for redrawing the maps of cardiovascular risk?

Coronary Artery Calcification and Plaque Characteristics in People Living With HIV: A Systematic Review and Meta‐Analysis

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