Parâmetros ecocardiográficos de deposição de gordura epicárdica e sua relação com doença arterial coronariana

Mustelier, Juan Valiente; Rego, Julio Oscar Cabrera; González, Ángela Gala; Sarmiento, Júlio César Gandarilla; Riverón, Beatriz Vega

doi:10.1590/s0066-782x2011005000068

Cited by 33 publications

(20 citation statements)

References 20 publications

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“…A recent meta-analysis showed that EAT may be an effective marker for the prediction of coronary heart disease [12]. In our study, mean EAT thickness in patients with coronary heart disease was 5.2 mm, similar to values reported by Mustelier et al [19], in another Hispanic population. This value is lower than others found in Japanese and USA populations [20,21], but higher than in the Korean population [18].…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Relationship between epicardial adipose tissue, coronary artery disease and adiponectin in a Mexican population

Yañez-Rivera

Baños-González

Blé-Castillo

et al. 2014

Cardiovasc Ultrasound

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BackgroundThe amount of epicardial adipose tissue (EAT) around the heart has been identified as an independent predictor of coronary artery disease (CAD), potentially through local release of inflammatory cytokines. Ethnic differences have been observed, but no studies have investigated this relationship in the Mexican population. The objective of the present study was to evaluate whether a relationship exist between EAT thickness assessed via echocardiography with CAD and adiponectin levels in a Mexican population.MethodsWe studied 153 consecutive patients who underwent coronary angiography and transthoracic echocardiography (TTE). EAT thickness on the free wall of the right ventricle was measured at the end of systole from parasternal long and short axis views of three consecutive cardiac cycles. Coronary angiograms were analyzed for the presence, extent and severity of CAD. Serum adiponectin, lipids, glucose, C-reactive protein and fibrinogen were determined.ResultsEAT thickness was greater in patients with CAD than in those without CAD from both parasternal long (5.39 ± 1.75 mm vs 4.00 ± 1.67 mm p < 0.0001) and short-axis views (5.23 ± 1.67 vs 4.12 ± 1.77, p = 0.001). EAT thickness measured from parasternal long and short-axis showed a statistically significant positive correlation with age (r = 0.354, p < 0.001; r = 0.286, p < 0.001 respectively), and waist circumference (r = 0.189, p = 0.019; r = 0.217, p = 0.007 respectively). A significant negative correlation between EAT thickness from the parasternal long axis with cholesterol-HDL was observed (r = -0.163, p = 0.045). No significant correlation was found between epicardial fat thickness and serum adiponectin or with the severity of CAD.ConclusionsEAT thickness was greater in patients with CAD. However, no correlation was observed with the severity of the disease or with serum adiponectin levels. EAT thickness measured by echocardiography might provide additional information for risk assessment and prediction of CAD.

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Section: Discussionsupporting

confidence: 90%

“…This result agrees with previous findings from Mustelier et al [19], but is in contrast with others [18,23]. The lack of association in this study could be partially attributed to the fact that EAT measurements are not performed at a specific anatomical site where the coronary stenosis is located.…”

Section: Discussionsupporting

confidence: 89%

Relationship between epicardial adipose tissue, coronary artery disease and adiponectin in a Mexican population

Yañez-Rivera

Baños-González

Blé-Castillo

et al. 2014

Cardiovasc Ultrasound

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“…Of these 11 studies, five studies were excluded because they did not report the detailed data for the meta-analysis [27-31]; two studies were excluded because of an investigation of the relationship between the EAT volume or area with CAD [32,33]; two studies were excluded because the study subjects were not well-defined or did not meet the criteria [15,34]; and the remaining two were letters and experimental studies [5,35]. The remaining 10 observational studies were eligible for the meta-analysis [11-14,16,17,19-21,36]. The flowchart of the search and selection of studies in this meta-analysis is illustrated in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…Current evidence about the association between location-specific EAT thickness at the right ventricular free wall and coronary artery disease (CAD) is still controversial. Several studies using echocardiography have demonstrated a significant relationship between CAD and location-specific EAT thickness measured at right ventricular free wall [13,14,16,17], while some studies using echocardiography or CT failed to observe a significant association [11,12,19,20]. Recent evidence has suggested that there is increasing attention on location-specific EAT thickness at the left AV groove as a potentially new biomarker associated with cardiometabolic risks by using 2D CT or MR measurement [11,19,21,22].…”

Section: Introductionmentioning

confidence: 99%

The relation of location-specific epicardial adipose tissue thickness and obstructive coronary artery disease: systemic review and meta-analysis of observational studies

Chou

et al. 2014

BMC Cardiovasc Disord

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BackgroundThere is growing evidence about the importance of epicardial adiposity on cardiometabolic risk. However, the relation of location-specific epicardial adipose tissue (EAT) thickness to coronary atherosclerotic burden is still unclear.MethodsThis meta-analysis was used to study the relations between location-specific EAT thickness and obstructive coronary artery disease (CAD). A systemic literature search to identify eligible studies that met the inclusion criteria from the beginning until January 2014 was made. We conducted the meta-analysis of all included 10 published studies. Pre-specified subgroup analyses were performed according to ethnicity, body mass index, diagnostic tools for CAD, and measurement tool if presence of high heterogeneity between studies. Potential publication bias was also assessed.ResultsWe identified ten observed studies with a total of 1625 subjects for planned comparison. With regard to the association between obstructive CAD and location-specific EAT thickness at the right ventricular free wall, caution is warranted. The pooled estimate showed that location-specific EAT thickness at the right ventricular free wall was significantly higher in the CAD group than non-CAD group (standardized mean difference (SMD): 0.70 mm, 95% CI: 0.26-1.13, P = 0.002), although heterogeneity was high (I2 = 93%). It should be clear that only the result of echocardiography-based studies showed a significant association (SMD: 0.98 mm, 95% CI: 0.43-1.53, P = 0.0005), and the result of all included CT-based studies showed a non-significant association (SMD: 0.06 mm, 95% CI: -0.12-0.25, P = 0.50). In the subgroup analysis, the “diagnostic tools for CAD” or “measurement tool of EAT thickness” are potential major sources of heterogeneity between studies. With regard to location-specific EAT thickness at the left atrioventricular (AV) groove, it was significantly higher in the CAD group than non-CAD group (SMD: 0.74 mm, 95% CI: 0.55-0.92, P <0.00001; I2 = 0%).ConclusionOur meta-analysis suggests that significantly elevated location-specific EAT thickness at the left AV groove is associated with obstructive CAD. Based on the current evidence, the location-specific EAT thickness at the left AV groove appears to be a good predictor in obstructive CAD, especially in Asian populations. Furthermore well-designed studies are warranted because of the current limited number of studies.

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“…Numerous studies have reported significant positive correlations between EAT mass and coronary artery disease (CAD) in humans [1], [2], [3]. In addition, significant correlation is reported between visceral obesity and EAT mass [4], [5].…”

Section: Introductionmentioning

confidence: 99%

Validation of Reference Genes for the Relative Quantification of Gene Expression in Human Epicardial Adipose Tissue

et al. 2012

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Background Relative quantification is a commonly used method for assessing gene expression, however its accuracy and reliability is dependent upon the choice of an optimal endogenous control gene, and such choice cannot be made a priori. There is limited information available on suitable reference genes to be used for studies involving human epicardial adipose tissue. The objective of the current study was to evaluate and identify optimal reference genes for use in the relative quantification of gene expression in human epicardial fat depots of lean, overweight and obese subjects. Methodology/Principal Findings Some of the commonly used reference genes including 18S , ACTB , RPL27 , HPRT , CYCA , GAPDH , RPLPO , POLR2A and B2M were quantified using real-time PCR analysis. The expression stability of these genes was evaluated using Genorm, Normfinder and Bestkeeper algorithms. In addition, the effect of sample size on the validation process was studied by randomly categorizing subjects in two cohorts of n = 2 and n = 33. Conclusions/Significance CYCA , GAPDH and RPL27 were identified as the most stable genes common to all three algorithms and both sample sizes. Their use as reference gene pairs might contribute to the enhanced robustness of relative quantification in the studies involving the human epicardial adipose tissue.

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Parâmetros ecocardiográficos de deposição de gordura epicárdica e sua relação com doença arterial coronariana

Cited by 33 publications

References 20 publications

Relationship between epicardial adipose tissue, coronary artery disease and adiponectin in a Mexican population

Relationship between epicardial adipose tissue, coronary artery disease and adiponectin in a Mexican population

The relation of location-specific epicardial adipose tissue thickness and obstructive coronary artery disease: systemic review and meta-analysis of observational studies

Validation of Reference Genes for the Relative Quantification of Gene Expression in Human Epicardial Adipose Tissue

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