Associação do índice tornozelo-braço com inflamação e alterações minerais ósseas em pacientes em hemodiálise

Miguel, Jair Baptista; Matos, Jorge Paulo Strogoff de; Ruzany, Frederico; Miguel, Claudia S.; Miguel, Sebastião J. S.; Naveiro, Luiz T.; Lugon, Jocemir Ronaldo

doi:10.1590/s0066-782x2011005000031

Cited by 4 publications

(9 citation statements)

References 24 publications

(57 reference statements)

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“…The prevalence of arterial hypertension in our study (82%) was higher than the Bahia study (71%) 9 , and higher than the analysis of six hemodialysis clinics in the State of Rio de Janeiro (61%) 10 ; it was also higher than the single center study conducted in the State of Rio de Janeiro (55%) 11 .…”

Section: Discussioncontrasting

confidence: 81%

“…Diabetes mellitus prevalence in this study (15%) was much lower than that found in the 2010 Census by the Brazilian Society of Nephrology (28%) 4 , lower than the Bahia study (21%) 9 , and lower than the single center study in the State of Rio de Janeiro (20%) 11 . However, it was similar to the analysis involving six hemodialysis clinics in the State of Rio de Janeiro (17%) 10 .…”

Section: Discussionsupporting

confidence: 71%

“…The mean age of the study population was 46 years, which is lower than that found in a study in the State of Rio de Janeiro 10 (54 years old), and also lower than another cross-sectional analysis conducted in a single dialysis center in the State of Rio de Janeiro, where the mean age was 52 years 11 . However, it was similar to the Bahia study 9 , which found a mean age of 49 years.…”

Section: Discussioncontrasting

confidence: 65%

“…A study in Bahia found a 56.6% of patients to be male 9 . A cross-sectional analysis conducted in six hemodialysis clinics in the State of Rio de Janeiro also found a higher proportion of men (56%) 10 .…”

Section: Discussionmentioning

confidence: 93%

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Survival and Predictive Factors of Lethality in Hemodyalisis: D/I Polymorphism of The Angiotensin I-Converting Enzyme and of the Angiotensinogen M235T Genes

Alves¹,

Silva²,

Salis³

et al. 2014

Arquivos Brasileiros De Cardiologia

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BackgroundEnd-stage kidney disease patients continue to have markedly increased cardiovascular disease morbidity and mortality. Analysis of genetic factors connected with the renin-angiotensin system that influences the survival of the patients with end-stage kidney disease supports the ongoing search for improved outcomes.ObjectiveTo assess survival and its association with the polymorphism of renin-angiotensin system genes: angiotensin I-converting enzyme insertion/deletion and angiotensinogen M235T in patients undergoing hemodialysis.MethodsOur study was designed to examine the role of renin-angiotensin system genes. It was an observational study. We analyzed 473 chronic hemodialysis patients in four dialysis units in the state of Rio de Janeiro. Survival rates were calculated by the Kaplan-Meier method and the differences between the curves were evaluated by Tarone-Ware, Peto-Prentice, and log rank tests. We also used logistic regression analysis and the multinomial model. A p value ≤ 0.05 was considered to be statistically significant. The local medical ethics committee gave their approval to this study.ResultsThe mean age of patients was 45.8 years old. The overall survival rate was 48% at 11 years. The major causes of death were cardiovascular diseases (34%) and infections (15%). Logistic regression analysis found statistical significance for the following variables: age (p = 0.000038), TT angiotensinogen (p = 0.08261), and family income greater than five times the minimum wage (p = 0.03089), the latter being a protective factor.ConclusionsThe survival of hemodialysis patients is likely to be influenced by the TT of the angiotensinogen M235T gene.

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Section: Discussioncontrasting

confidence: 81%

Section: Discussionsupporting

confidence: 71%

Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 93%

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Survival and Predictive Factors of Lethality in Hemodyalisis: D/I Polymorphism of The Angiotensin I-Converting Enzyme and of the Angiotensinogen M235T Genes

Alves¹,

Silva²,

Salis³

et al. 2014

Arquivos Brasileiros De Cardiologia

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“…To better estimate the impact of bone mineral disturbances on our findings, cumulative exposure was assessed through calculation of the mean of all values for serum calcium, phosphorus and intact parathyroid hormone (i-PTH) measurements along the 36-month period preceding the ABI evaluation or since hemodialysis initiation for patients on dialysis for less than 3 years, as described previously. 16 Calcium and phosphorus serum levels were measured on a monthly basis and i-PTH every six months. All routine blood analyses were performed in a central laboratory.…”

Section: Methodsmentioning

confidence: 99%

Ankle-Brachial Index as a Predictor of Mortality in Hemodialysis: A 5-Year Cohort Study

Miguel¹,

Matos²,

Lugon³

2017

Arquivos Brasileiros De Cardiologia

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BackgroundAbnormal ankle-brachial index (ABI) has been found to be a strong predictor of mortality in some hemodialysis populations in studies with relatively short periods of follow-up, lower than 2 years.ObjectiveThis study aimed to assess the predictive value of abnormal ABI as a risk factor for death among patients on maintenance hemodialysis after a 5-year follow-up.MethodsA total of 478 patients on hemodialysis for at least 12 months were included in the study. ABI measurement was performed using a mercury column sphygmomanometer and portable Doppler. Patients were divided into 3 groups according to ABI (low: <0.9; normal: 0.9 to 1.3; and high: >1.3) and followed for a 60-month period.ResultsThe prevalence rates of low, normal and high ABI were 26.8%, 64.6% and 8.6%, respectively. The 5-year survival rate was lower in the groups with low ABI (44.1%, P<0.0001) and high ABI (60.8%, P= 0.025) than in the group with normal ABI (71.7%). Cox regression was used to evaluate the association between ABI and mortality, adjusting for potential confounders. Using normal ABI as reference, a low, but not a high ABI was found to be an independent risk factor for all-cause mortality (HR2.57; 95% CI, 1.84-3.57 and HR 1.62; 95% CI, 0.93-2.83, respectively).Conclusionslong-term survival rates of patients with either low or high ABI were lower than the one from those with normal ABI. However, after adjustment for potential confounders, only low ABI persisted as an independent risk factor for all-cause mortality among hemodialysis patients.

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Peripheral arteriopathy in adults from three Family Health Units of Paraguay in 2019

Rivelli

Gabetta

Amarilla

et al. 2020

Rev. virtual Soc. Parag. Med. Int

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Introducción: la detección de enfermedad arterial periférica permite identificar a un grupo de alto riesgo cardiovascular. La prueba del índice tobillo-brazo con esfigmomanómetro digital es una técnica muy fiable, fácil de aplicar y de interpretar. Objetivos: determinar la frecuencia y características clínicas de la enfermedad arterial periférica en sujetos adultos de Atención Primaria de Areguá, Paraguay, en el 2019. Metodología: estudio observacional, descriptivo, prospectivo, multicéntrico. Se incluyó a varones y mujeres mayores de 50 años que asisten a tres Unidades de Salud Familiar de Areguá, Paraguay, en el 2019. Previo consentimiento informado, todos fueron sometidos a determinaciones socioeconómicas, clínicas y detección del índice tobillo-brazo con esfigmomanómetro digital. Se consideró anormal todo índice tobillo-brazo <0,9. Resultados: se incluyeron 124 pacientes, con edad media 64±8 años. Predominaron los sujetos del sexo femenino, con escolaridad primaria, casados y sin independencia económica. Las comorbilidades más frecuentes fueron la hipertensión arterial y diabetes mellitus. Se detectaron 7 casos (5,6%) compatibles con arteriopatía periférica. Entre éstos, sólo 43% referían claudicación intermitente de miembros. Conclusiones: la frecuencia de índice tobillo-brazo compatible con arteriopatía periférica fue 5,6%. Entre éstos, los síntomas de claudicación de miembros fueron referidos por 43%.

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Associação do índice tornozelo-braço com inflamação e alterações minerais ósseas em pacientes em hemodiálise

Abstract: Background: Reduced ankle-arm index (AAI), inflammation and mineral bone disorder (MBD) are all associated with increased risk of death and cardiovascular complications in patients on hemodialysis (HD), but the association between them deserves clarification.

Cited by 4 publications

References 24 publications

Survival and Predictive Factors of Lethality in Hemodyalisis: D/I Polymorphism of The Angiotensin I-Converting Enzyme and of the Angiotensinogen M235T Genes

Survival and Predictive Factors of Lethality in Hemodyalisis: D/I Polymorphism of The Angiotensin I-Converting Enzyme and of the Angiotensinogen M235T Genes

Ankle-Brachial Index as a Predictor of Mortality in Hemodialysis: A 5-Year Cohort Study

Peripheral arteriopathy in adults from three Family Health Units of Paraguay in 2019

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