Sistema renina-angiotensina: é possível identificar genes de suscetibilidade à hipertensão?

Lima, Sandro Gonçalves de; Hatagima, Ana; Silva, Norma Lucena Cavalcanti L. da

doi:10.1590/s0066-782x2007001800013

Cited by 10 publications

(12 citation statements)

References 48 publications

(62 reference statements)

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“…It was decided to study the I/D ACE and M235T AGT polymorphisms owing to the current controversy in the literature with respect to the real relation between such polymorphisms and hypertension. 7 In this study, no association was identified between the I/D polymorphisms of ACE and M235T of AGT with EBPR. However, it is possible that this association exists in populations where there is an association between these polymorphisms with hypertension, considering that EBPR is a pre-clinical stage of hypertension.…”

Section: Discussioncontrasting

confidence: 54%

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Exaggerated blood pressure response during exercise treadmill testing: functional and hemodynamic features, and risk factors

et al. 2012

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The factors which contribute to an exaggerated blood pressure response (EBPR) during the exercise treadmill test (ETT) are not wholly understood. The association between the insertion/deletion polymorphisms of the angiotensin-converting enzyme (ACE) and M235T of the angiotensinogen with EBPR during ETT still remains unstudied. To identify and compare the risk factors for hypertension between normotensive subjects with EBPR and those who exhibit a normal curve of blood pressure (BP) during ETT. In a series of EBPR cases from a historical cohort of normotensive individuals, a univariate analysis was performed to estimate the association of the studied factors with BP behavior during ETT. Additionally, logistic multivariate regression was conducted to analyze the joint effects of the variables. P-values above 0.05 were considered statistically significant. From a total of 10 027 analyzed examinations, only 219 met the criteria employed to define EBPR, which resulted in a prevalence of 12.6%. For the systolic component of the BP, hyperreactive subjects displayed a mean age and body mass index (BMI) significantly higher than the others (P¼0.002 and o0.001, respectively). No association was observed between the polymorphisms cited above and EBPR. An analysis of the joint effect of variables has indicated that only age (Po 0.001) and BMI (P¼0.001) were specifically associated with systolic BP during exercise. Age and BMI were the only factors that independently influenced EBPR during ETT.

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Section: Discussioncontrasting

confidence: 54%

“…Contradictory findings have also been described concerning an association between the M235T polymorphism of the angiotensinogen gene (AGT) and hypertension. 7 However, to date, any association between such polymorphisms and EBPR during ETT has remained unstudied.…”

Section: Introductionmentioning

confidence: 99%

Exaggerated blood pressure response during exercise treadmill testing: functional and hemodynamic features, and risk factors

et al. 2012

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“…Some studies have shown an association of the D allele with hypertension 3,13,14, while others have reported a complete lack of any association between the mutation and the phenotype 3,15,16. The same may be observed in relation to the association between hypertension and M235T polymorphism 13,14,17,18.…”

Section: Discussionmentioning

confidence: 90%

“…However, many studies may have underestimated the impact of these genes, since behavioral patterns such as obesity, excessive alcohol consumption, exercise, among other classical risk factors, can also be modulated by genetic factors 2. Several genes, which encode the renin-angiotensin system proteins, have been implicated in the etiopathogeny of hypertension, although there are conflicting results amongst studies 3.…”

Section: Introductionmentioning

confidence: 99%

Exaggerated blood pressure response during the exercise treadmill test as a risk factor for hypertension

Lima

Albuquerque

Oliveira

et al. 2013

Braz J Med Biol Res

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Exaggerated blood pressure response (EBPR) during the exercise treadmill test (ETT) has been considered to be a risk factor for hypertension. The relationship of polymorphisms of the renin-angiotensin system gene with hypertension has not been established. Our objective was to evaluate whether EBPR during exercise is a clinical marker for hypertension. The study concerned a historical cohort of normotensive individuals. The exposed individuals were those who presented EBPR. At the end of the observation period (41.7 months = 3.5 years), the development of hypertension was analyzed within the two groups. Genetic polymorphisms and blood pressure behavior were assessed as independent variables, together with the classical risk factors for hypertension. The I/D gene polymorphism of the angiotensin-converting enzyme and M235T of angiotensinogen were ruled out as risk factors for hypertension. EBPR during ETT is not an independent influence on the chances of developing hypertension. No differences were observed between the hypertensive and normotensive individuals regarding gender (P = 0.655), skin color (P = 0.636), family history of hypertension (P = 0.225), diabetes mellitus (P = 0.285), or hypertriglyceridemia (P = 0.734). The risk of developing hypertension increased with increasing body mass index (BMI) and advancing age. The risk factors, which independently influenced the development of hypertension, were age and BMI. EBPR did not constitute an independent risk factor for hypertension and is probably a preclinical phase in the spectrum of normotension and hypertension.

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“…7 Os benefícios da perda de peso por meio de exercícios e atividade física para a redução da pressão sanguínea em crianças foram de-monstrados e sugeridos em estudos observacionais e de intervenção. 8,9 O excesso de peso está diretamente associado à presença de HA já na infância 9,13 , portanto, o esclarecimento dos profissionais da saúde, dos familiares e educadores é fundamental para que a prevenção e o tratamento da obesidade sejam alcançados com êxito. 9 A HA infantil é uma patologia com alta morbidade, além de ser preditora de HA na vida adulta, assim tanto a prevenção quanto o diagnóstico precoce, nas primeiras etapas da vida, são essenciais.…”

Section: Introductionunclassified

Estado nutricional e níveis pressóricos de escolares adolescentes da cidade de Cubatão - SP, Brasil

Silva

Ramos

Costa

2008

J. Hum. Growth Dev.

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O aumento da prevalência de obesidade em adolescentes tem contribuído para o aparecimento precoce da hipertensão arterial. OBJETIVOS: Verificar o estado nutricional e os níveis pressóricos de adolescentes, bem como a relação entre estes fatores e diferenças entre os sexos. MÉTODO: Estudo descritivo com delineamento transversal realizado em duas escolas públicas da cidade de Cubatão. Participaram 704 adolescentes de 10 a 15 anos de idade, sendo 333 rapazes e 371 moças. Para avaliação do estado nutricional foi utilizado o índice de massa corporal por idade e sexo. A pressão arterial foi medida por meio da técnica auscultatória e os valores encontrados foram avaliados de acordo com o percentil de estatura para a idade dos adolescentes. O tratamento estatístico constou da apresentação da proporção dos sujeitos em sobrepeso e obesidade, bem como dos que apresentavam alterações na pressão arterial. Foi utilizado o teste Qui-quadrado para verificar diferença de proporção de alterações pressóricas entre sujeitos eutróficos e com sobrepeso ou obesidade, além do cálculo de Odds Ratio e IC95%. A significância estatística adotada foi de p < 0,05. RESULTADOS: A avaliação do estado nutricional mostrou que 13,64% dos adolescentes apresentavam sobrepeso e 10,37% eram obesos. Quanto aos níveis pressóricos, 12,65% dos adolescentes apresentaram pressão Normal Alta e 9,52% apresentaram Hipertensão. Os adolescentes com excesso de peso apresentaram significativamente maior proporção de alterações pressóricas: X² = 15,39 (p = 0,00008); OR = 2,23 (IC% = 1,47-3,37). CONCLUSÃO: Os resultados mostraram elevadas proporções de excesso de peso e alterações pressóricas, com clara relação entre eles.

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Sistema renina-angiotensina: é possível identificar genes de suscetibilidade à hipertensão?

Cited by 10 publications

References 48 publications

Exaggerated blood pressure response during exercise treadmill testing: functional and hemodynamic features, and risk factors

Exaggerated blood pressure response during exercise treadmill testing: functional and hemodynamic features, and risk factors

Exaggerated blood pressure response during the exercise treadmill test as a risk factor for hypertension

Estado nutricional e níveis pressóricos de escolares adolescentes da cidade de Cubatão - SP, Brasil

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