A exposição crônica à fumaça do cigarro resulta em remodelação cardíaca e prejuízo da função ventricular em ratos

Castardeli, Edson; Paiva, Sérgio Alberto Rupp de; Matsubara, Beatriz Bojikian; Matsubara, Luiz Shiguero; Minicucci, Marcos F.; Azevedo, Paula Schmidt; Campana, Álvaro Oscar; Zornoff, Leonardo A. M.

doi:10.1590/s0066-782x2005000400009

Cited by 35 publications

(8 citation statements)

References 24 publications

(25 reference statements)

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“…Likewise exposure to cigarette smoke for four months resulted in ventricular dilatation, with a reduction in the systolic function. Interestingly enough these changes were accompanied by a slight increase in blood pressure 28 . Therefore, although the mechanisms have not yet been suffi ciently explained, the set of evidences presented suggests that the activation of neurohormonal factors could play at least a partial role in the mechanisms associated with the effects of tobacco.…”

Section: Cigarette Smoke Exposure Intensifies Ventricular Remodeling mentioning

confidence: 95%

A exposição à fumaça de cigarro intensifica a remodelação ventricular após o infarto agudo do miocárdio

Zornoff

Matsubara

et al. 2006

Arq. Bras. Cardiol.

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Section: Cigarette Smoke Exposure Intensifies Ventricular Remodeling mentioning

confidence: 95%

A exposição à fumaça de cigarro intensifica a remodelação ventricular após o infarto agudo do miocárdio

Zornoff

Matsubara

et al. 2006

Arq. Bras. Cardiol.

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“…It is interesting to raise the hypothesis that the period of exposure to SSCS used in our published study (three weeks) was not enough to induce changes in baroreflex sensitivity in Wistar rats. Conversely, a previous investigation that used a similar protocol to expose rats to mainstream cigarette smoke reported that chronic exposure induces cardiac remodeling that is characterized by a decrease in ventricular functional capacity [8]. Taken together, based on the studies cited above, we may propose that cigarette smoke exposure during three weeks is able to damage cardiac function without influence the autonomic regulation of the heart.…”

Section: Discussionmentioning

confidence: 83%

Sidestream cigarette smoke and cardiac autonomic regulation

Valenti¹,

Vanderlei²,

Ferreira³

et al. 2013

Int Arch Med

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BackgroundThe literature has already demonstrated that cigarette influences the cardiovascular system. In this study, we performed a literature review in order to investigate the relationship between sidestream cigarette smoke (SSCS) and cardiac autonomic regulation.MethodsSearches were performed on Medline, SciELO, Lilacs and Cochrane databases using the crossing between the key-words: “cigarette smoking”, “autonomic nervous system”, “air pollution” and “heart rate variability”.ResultsThe selected studies indicated that SSCS exposure affects the sympathetic and parasympathetic responses to changes in arterial blood pressure. Moreover, heart rate responses to environmental tobacco smoke are increased in smokers compared to non-smokers. The mechanism involved on this process suggest increased oxidative stress in brainstem areas that regulate the cardiovascular system.ConclusionFurther studies are necessary to add new elements in the literature to improve new therapies to treat cardiovascular disorders in subjects exposed to sidestream cigarette smoke.

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“…In the proximal region of the tail, a sensor (KSM-microfone) was placed and coupled to the plethysmograph. Blood pressure was recorded on paper with the polygraph at a 2.5-mm/s velocity 22 . A value superior to 150 mmHg was considered the inclusion criterion for hypertension by mean of three consecutive measurements 23 .…”

Section: Methodsmentioning

confidence: 99%

Effect of exercise on the maternal outcome in pregnancy of spontaneously hypertensive rats

Rocha

Peraçoli

Volpato³

et al. 2014

Acta Cir. Bras.

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PURPOSE:To evaluate the effect of exercise (swimming) on pregnancy in spontaneously hypertensive rats (SHR). METHODS:Thirty three pregnant female SHR were distributed into three groups (n=11 animals/group): SHR Control=non-exercised (sedentary); SHR Ex0 = exercised from day zero to day 20 of pregnancy; and SHR Ex7 = exercised from day 7 to 20 of pregnancy. Body weight and systolic blood pressure were indirectly measured during pregnancy. On gestational day 21, the rats were anaesthetized and uterine content was withdrawn for analysis of maternal reproductive outcome parameters and fetal development. RESULTS:The reduced blood pressure percentage was higher in SHR Ex0 and SHR Ex7 compared to SHR Control group. Weight gain was present in all pregnancy periods, but it was lower in SHR Ex7 than in SHR Control dams. The exercise increased the preimplantation loss rate. The post-implantation loss rate was lower in SHR Ex0 group. SHR Ex7 group showed a significantly higher percentage of fetuses classified as small for gestational age as compared to others groups. CONCLUSION:The exercise contributed to lowering gestational blood pressure in SHR rats, but had a negative impact on the developing embryo.

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A exposição crônica à fumaça do cigarro resulta em remodelação cardíaca e prejuízo da função ventricular em ratos

Abstract: Chronic cigarette smoke exposure results in cardiac remodeling with a decrease in ventricular functional capacity.

Cited by 35 publications

References 24 publications

A exposição à fumaça de cigarro intensifica a remodelação ventricular após o infarto agudo do miocárdio

A exposição à fumaça de cigarro intensifica a remodelação ventricular após o infarto agudo do miocárdio

Sidestream cigarette smoke and cardiac autonomic regulation

Effect of exercise on the maternal outcome in pregnancy of spontaneously hypertensive rats

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