Efeitos Cardiovasculares da Testosterona

Gebara, Otavio C.E.; Vieira, Núbia Welerson; Meyer, Jayson W.; Calich, Ana Luisa; Tai, Eun J.; Pierri, Humberto; Wajngarten, Maurı́cio; Aldrighi, José Mendes

doi:10.1590/s0066-782x2002001500013

Cited by 12 publications

(9 citation statements)

References 38 publications

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“…A progressive increase in plasma insulin concentrations is associated with aging (Gebara and others 2002; Ezaki 2006; Celec and others 2007), insulin resistance, and glucose intolerance. Serum insulin concentrations revealed that there is no significant difference among groups; however, animals that received the soybean‐based diet (non‐GMS and GMS) presented insulin concentrations slight lower than those of CG.…”

Section: Discussionmentioning

confidence: 99%

“…Aging is generally associated with changes in the cardiovascular system, particularly in the structure and function of the arteries. Structural and functional changes in the arteries become evident in the aging process, causing cardiac hypertrophy, myocardial fibrosis, and artery thickening with collagen accumulation in the animals’ heart tissue (Gray and others 1991; Águila and Mandarim‐de‐Lacerda 2001; Gebara and others 2002; Catalano and others 2005; Ezaki 2006). …”

Section: Discussionmentioning

confidence: 99%

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The Impact of Non‐ and Genetically Modified Soybean Diets in Aorta Wall Remodeling

Daleprane

Chagas

Vellarde

et al. 2010

Journal of Food Science

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The aim of this study was to evaluate the influence of nongenetically modified soybean (non-GMS) and genetically modified soybean (GMS) meal on growth and cardiometabolic parameters in rats. Thirty male Wistar rats were divided into 3 groups (n= 10): non-GMS, GMS, and control group (CG). All animals received water and an isocaloric diet ad libitum for 455 d. Blood was drawn by cardiac puncture, and serum was separated for subsequent biochemical analyses (total cholesterol, triacylglycerols, insulin, glucose, and testosterone). The aorta was quickly harvested and fixed; the body fat mass was removed and weighed. Non-GMS and GMS had a growth index (GI) similar to CG but with a lower body weight (P < 0.05) and a lower amount of body fat mass (P < 0.05). Total cholesterol, triacylglycerol, glucose concentrations, and aortic tunics were reduced (P < 0.05) in non-GMS and GMS compared to CG. Non-GMS and GMS are able to reduced serum cholesterol, triacylglycerols, glucose, and aortic remodeling in aged rats. No differences were observed between non-GMS and GMS in all parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Impact of Non‐ and Genetically Modified Soybean Diets in Aorta Wall Remodeling

Daleprane

Chagas

Vellarde

et al. 2010

Journal of Food Science

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“…Com o envelhecimento, ocorre uma diminuição nas concentrações isoladas de testosterona livre e total. Após os 50 anos, a concentração sérica de testosterona apresenta diminuição de 1% ao ano 14 . Essa redução está diretamente relacionada ao hipogonadismo 21 (2000) 1 verificou esta mesma relação da insulina com a testosterona, quando os grupos ingeriram uma refeição completa (carboidrato, gordura e proteína) ou somente uma bebida rica em carboidratos, ou somente uma suplementação constituída de proteína e carboidrato, imediatamente, 2 e 4 horas após a sessão de treinamento.…”

Section: Autorunclassified

A influência do treinamento de força e do treinamento aeróbio sobre as concentrações hormonais de testosterona e cortisol

Araújo¹

2008

Motricidade

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“…The adrenal gland produces residual quantities of testosterone. In women, the adrenal gland is responsible for the production of between 50% and 60% of androgenic requirements, but in men, the biological significance of this secretion is minimal 11,12 . The steroid hormones produced by the gonads have a fundamental role in the metabolism of lipids and proteins.…”

mentioning

confidence: 99%

“…The steroid hormones produced by the gonads have a fundamental role in the metabolism of lipids and proteins. From among the androgens, testosterone has an important effect on the circulating levels of cholesterol, increasing lowdensity lipoproteins and reducing high-density lipoproteins 11 . It seems that the direct replacement of testosterone does not affect cluster headache attacks, possibly because synthetic testosterone does not reach hypothalamic receptors.…”

mentioning

confidence: 99%

Clomiphene treatment may be effective in refractory episodic and chronic cluster headache

Nobre

Peres

Moreira

et al. 2017

Arq. Neuro-Psiquiatr.

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Objective: To describe the evolution of 15 patients who were treated for difficult-to-control episodic and chronic cluster headaches with clomiphene. Methods: Clomiphene treatment was used for seven chronic and eight episodic cluster headache patients. The chronic patients were refractory to the medication being used, and the episodic patients, in addition to being resistant to conventional medication, had longer cluster headache periods, exceeding the average time of previous cluster cycles. Our main analysis was of the time to pain-free, complete remission, and the length of pain-free time and complete remission. Results: Clomiphene was used for 45-180 days. The average time to being pain-free was 15 days and cluster remission was up to 60 days. The average time between being pain-free until cluster remission was 26 days. Conclusions: Clomiphene treatment was significantly efficient. It interrupted chronicity in all patients, suggesting the capability of changing the pattern of attacks. It proved to be safe and well tolerated. Keywords: headache; therapeutics; testosterone; clomiphene; hypothalamus RESUMO Objetivo: Descrever a evolução de 15 casos de cefaleia em salvas de difícil controle, episódicos e crônicos, tratados com clomifeno. Métodos: Foram tratados 7 casos crônicos e 8 episódicos. Os crônicos, refratários aos medicamentos preventivos em uso e os episódicos, além de refratários, apresentaram salva mais longa que as anteriores. Foram analisados o tempo para a ausência das crises, fim da salva e o tempo entre os dois parâmetros. Resultados: O clomifeno foi usado por 45 a 180 dias. A média de tempo para a remissão das crises foi de 15 dias e da salva foi de 60 dias. A média entre o fim das crises e da salva foi de 26 dias. Conclusão: O clomifeno foi eficaz em ambos os padrões. Foi capaz de interromper a cronicidade em todos os casos, o que sugere uma ação neuromodulatória capaz de mudar o padrão das crises. Mostrou-se seguro e bem tolerado.Palavras-chave: cefaleia; terapêutica; testosterona; clomifeno; hipotálamo Patients who were treated for difficult-to-control episodic and chronic cluster headaches and results are described. Hypothalamic modulation by means of hormone treatment seems to be the new solution for preventive treatment.Cluster headache is certainly the most painful and incapacitating of primary headaches, particularly for patients who suffer from long bouts or for those who present with the chronic form. Cluster headaches are characterized by a periorbital unilateral pain associated with ipsilateral autonomic signs (ptosis, miosis, conjunctival hyperemia, tearing, rhinorrhea, nasal congestion). Its episodic form is characterized by weeks or months (cluster periods) of pain, separated by painfree intervals of months or years 1 . Chronic cluster headaches affect nearly 10% of patients and episodes persist for at least one year with no remission or with remissions that last for at least one month. These patients usually need one or two preventive drugs such as corticosteroids, verapa...

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Efeitos Cardiovasculares da Testosterona

Cited by 12 publications

References 38 publications

The Impact of Non‐ and Genetically Modified Soybean Diets in Aorta Wall Remodeling

The Impact of Non‐ and Genetically Modified Soybean Diets in Aorta Wall Remodeling

A influência do treinamento de força e do treinamento aeróbio sobre as concentrações hormonais de testosterona e cortisol

Clomiphene treatment may be effective in refractory episodic and chronic cluster headache

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