The Impact of Non‐ and Genetically Modified Soybean Diets in Aorta Wall Remodeling

Daleprane, Julio Beltrame; Chagas, Mauricio Alves; Vellarde, Guillermo C.; Ramos, Cristiane F.; Boaventura, Gilson Teles

doi:10.1111/j.1750-3841.2010.01773.x

Cited by 11 publications

(4 citation statements)

References 50 publications

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“…Two long-term studies over 455 days were conducted to evaluate the influence of genetically modified soybean on growth, hematological indicators and cardiometabolic parameters in Wistar rats. No differences were observed between GM and non-GM groups in all parameters (Daleprane et al, 2009(Daleprane et al, , 2010. Steinke et al (2010) performed a long-term study over 25 months to evaluate the effects of genetically modified corn on performance of lactating dairy cows, and they demonstrated that the GM corn has no obvious influence on the performance variables of cows over 25 months.…”

Section: Discussionmentioning

confidence: 94%

Long-term toxicity study on transgenic rice with Cry1Ac and sck genes

Zhang

Zhuo

Tian

et al. 2014

Food and Chemical Toxicology

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Section: Discussionmentioning

confidence: 94%

Long-term toxicity study on transgenic rice with Cry1Ac and sck genes

Zhang

Zhuo

Tian

et al. 2014

Food and Chemical Toxicology

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“…High-throughput “-omics” – transcriptomics, proteomics, and metabolomics - methods have been suggested as a nontargeted approach to detect unintended effects in GE plants. Long-term studies included rats [20,30-32], mice [33-37], salmon [38,39], beef cattle [40], dairy cows [41], macaques [42], pigs [19], and quail [43]. Multigenerational studies included rats [44-48], mice [49-53], pigs [54-56], bulls [56], dairy cows [56], goats [57], sheep [56,58], broilers [56,59], laying hens [56,60], and quail [21,61].…”

Section: Introductionmentioning

confidence: 99%

GMOs in animal agriculture: time to consider both costs and benefits in regulatory evaluations

Eenennaam

2013

J Animal Sci Biotechnol

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In 2012, genetically engineered (GE) crops were grown by 17.3 million farmers on over 170 million hectares. Over 70% of harvested GE biomass is fed to food producing animals, making them the major consumers of GE crops for the past 15 plus years. Prior to commercialization, GE crops go through an extensive regulatory evaluation. Over one hundred regulatory submissions have shown compositional equivalence, and comparable levels of safety, between GE crops and their conventional counterparts. One component of regulatory compliance is whole GE food/feed animal feeding studies. Both regulatory studies and independent peer-reviewed studies have shown that GE crops can be safely used in animal feed, and rDNA fragments have never been detected in products (e.g. milk, meat, eggs) derived from animals that consumed GE feed. Despite the fact that the scientific weight of evidence from these hundreds of studies have not revealed unique risks associated with GE feed, some groups are calling for more animal feeding studies, including long-term rodent studies and studies in target livestock species for the approval of GE crops. It is an opportune time to review the results of such studies as have been done to date to evaluate the value of the additional information obtained. Requiring long-term and target animal feeding studies would sharply increase regulatory compliance costs and prolong the regulatory process associated with the commercialization of GE crops. Such costs may impede the development of feed crops with enhanced nutritional characteristics and durability, particularly in the local varieties in small and poor developing countries. More generally it is time for regulatory evaluations to more explicitly consider both the reasonable and unique risks and benefits associated with the use of both GE plants and animals in agricultural systems, and weigh them against those associated with existing systems, and those of regulatory inaction. This would represent a shift away from a GE evaluation process that currently focuses only on risk assessment and identifying ever diminishing marginal hazards, to a regulatory approach that more objectively evaluates and communicates the likely impact of approving a new GE plant or animal on agricultural production systems.

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“…GM soybean reduced TC and TG levels in human [15], and in hamsters [16]. Serum TG was significantly increased in rat fed on GM maize [13].…”

Section: Do Genetic Engineering Products Produce Long-term Effects?mentioning

confidence: 92%

Impacts of Genetically Modified Food on Insulin Hormone, Glucose, and Lipid Profile of Male and Female Wister Albino Rats

Salama

Din²,

Wahed³

2022

Journal of Scientific Research in Science

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In recent years, genetically modified (GM) crops aim to produce food \ and feed which has become part of the usual agriculture in many areas of the world. Whether GM food and feed have positive or negative impacts on humans or animals is still unclear. Therefore, an investigation of the effects of different diets containing genetically modified food (GMF) on insulin hormone, glucose, and lipid profile were carried out in the present study. Male and female Wister Albino rats70-80 g range body weight was used in the present study. Each sex was divided into 4 groups (n = 10 per group). Control group fed on the basal diet American Institute of Nutrition for Growth (AIN93 G) and three treated groups were given GM (corn, wheat, and rice) and water adlibitum for three months. The reason for choosing these foods is because they are the most basic foods consumed in our daily life (bread and rice). At the end of the experimental period results compared to the control group GM (corn, wheat, and rice) for both sexes showed a significant decrease in serum insulin and the significant increase in serum glucose. Also, significant increase in total cholesterol (TC) , triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), very low density lipoproteins (VLDL), Risk ratio I and Risk ratio II. Yet, serum high density lipoproteins cholesterol (HDL-C) levels showed significant decrease in all groups. Body weight showed a significant increase in all groups of males and female rats.

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The Impact of Non‐ and Genetically Modified Soybean Diets in Aorta Wall Remodeling

Cited by 11 publications

References 50 publications

Long-term toxicity study on transgenic rice with Cry1Ac and sck genes

Long-term toxicity study on transgenic rice with Cry1Ac and sck genes

GMOs in animal agriculture: time to consider both costs and benefits in regulatory evaluations

Impacts of Genetically Modified Food on Insulin Hormone, Glucose, and Lipid Profile of Male and Female Wister Albino Rats

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