Influence of caffeine on blood pressure and platelet aggregation

Cavalcante, José; Santos, Paulo Roberto M.; Menezes, Marcus G. F. de; Marques, Hedylamar Oliveira; Cavalcante, Leonardo Pessoa; Pacheco, Walewska S.

doi:10.1590/s0066-782x2000000800002

Cited by 23 publications

(17 citation statements)

References 7 publications

(7 reference statements)

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“…This did not achieve statistical trend status for the untargeted study, but was verified by targeted analyses. The effect of caffeine consumption on function of PLTs is controversial, with some investigators reporting an effect and others not; [18][19][20][21] however, to the best of our knowledge, only one study has reported that addition of caffeine to PLTs had effects that may be relevant to PLT storage. 22 It is unclear from the current data if caffeine has a direct effect itself, if metabolites of caffeine have an effect, or if caffeine is simply associated with other factors that affect PLT biology.…”

Section: Discussionmentioning

confidence: 99%

Metabolites in stored platelets associated with platelet recoveries and survivals

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Metabolites in stored platelets associated with platelet recoveries and survivals

et al. 2016

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“…In healthy people, moderate caffeine consumption (400 mg/day) neither induces cardiac arrhythmia nor increases serum cholesterol levels [3]. However, excessive coffee consumption is known to result in mineral deficiency, hypertension, hypercholesterolemia, insomnia, tremors, nausea, polyuria, diarrhea, and polyphagia [2][3][4][5][6]. Possibly, the positive effects of coffee are caused by certain compounds such as CF and CGA [3,7].…”

Section: Introductionmentioning

confidence: 99%

Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (Coffea arabica)

et al. 2020

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Coffee is rich in caffeine (CF), chlorogenic acid (CGA) and phenolics. Differing types of coffee beverages and brewing procedures may result in differences in total phenolic contents (TPC) and biological activities. Inflammation and increases of platelet activation and aggregation can lead to thrombosis. We focused on determining the chemical composition, antioxidant activity and inhibitory effects on agonist-induced platelet aggregation and cyclooxygenase (COX) of coffee beverages in relation to their preparation method. We prepared instant coffee and brewed coffee beverages using drip, espresso, and boiling techniques. Coffee extracts were assayed for their CF and CGA contents using HPLC, TPC using colorimetry, platelet aggregation with an aggregometer, and COX activity using ELISA. The findings have shown all coffee extracts, except the decaffeinated types, contained nearly equal amounts of CF, CGA, and TPC. Inhibitory effects of coffee extracts on platelet aggregation differed depending on the activation pathways induced by different agonists. All espresso, drip and boiled coffee extracts caused dose dependent inhibition of platelet aggregation induced by ADP, collagen, epinephrine, and arachidonic acid (ARA). The most marked inhibition was seen at low doses of collagen or ARA. Espresso and drip extracts inhibited collagen-induced platelet aggregation more than purified caffeine or CGA. Espresso, boiled and drip coffee extracts were also a more potent inhibitors of COX-1 and COX-2 than purified caffeine or CGA. We conclude that inhibition of platelet aggregation and COX-1 and COX-2 may contribute to anti-platelet and anti-inflammatory effects of espresso and drip coffee extracts.

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“…Como alguns estudos demonstram, a cafeína pode agir diretamente na resistência vascular periférica, provocando vasoconstrição com conseqüente aumento da pressão arterial 14 .…”

Section: Resultsunclassified

Prevalência e fatores associados à hipertensão em trabalhadores do transporte coletivo urbano no Brasil

Souza¹,

Silva²,

Silva³

et al. 2017

Rev. Bras. Med. Trab.

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Hipertensão arterial em motoristas RESUMO: RESUMO: RESUMO: RESUMO: RESUMO: Estudo transversal com objetivo de investigar fatores de risco cardiovascular em motoristas e cobradores de ônibus e analisar a relação dos valores de pressão arterial e glicemia com demais fatores de risco. Realizado em Fortaleza-Ceará, em 2005, mediante entrevista e avaliação antropométrica, glicêmica e medida da pressão arterial com 124 motoristas e 96 cobradores. Verificou-se valores da pressão arterial limítrofes ou alterados em 49,2%; 72,9% com sobrepeso e obesidade; 87,3% sedentários; 53,4% ingeriam bebida alcoólica; e 73,6% consumiam gordura animal. Encontrou-se correlação estatisticamente relevante entre consumo de gordura animal e valores médios elevados de pressão arterial sistólica e entre consumo reduzido do sal, glicemia e pressão arterial diastólica. Isso sugere dificuldade para avaliar este aspecto a partir da informação do participante. Evidenciou-se presença de significativos fatores de risco cardiovascular, o que indica a necessidade da implementação de ações educativas visando especialmente o desenvolvimento de atividades físicas e alimentação adequada. Palavras-chave: Palavras-chave: Palavras-chave: Palavras-chave: Palavras-chave: Hipertensão; fator de risco; saúde do trabalhador; trabalho. ABSTRACT ABSTRACT ABSTRACT ABSTRACT ABSTRACT: : :: : This cross-sectional study aims at both investigating cardiovascular risk factors to workers from an urban transport company and analyzing the relation of blood pressure values and glucose with other risk factors. It was carried out in Fortaleza-Ceará, Brazil, in 2005, by means of interviews and anthropometric evaluation, glucose evaluation, and blood pressure measurements with 124 drivers and 96 collectors. Results demonstrated that 49.2% had borderline or modified blood pressure values; 72.9% were overweight and obese; 87.3% were sedentary; 53.4% ingested alcohol; and 73.6% ate animal fat. There was significant statistic correlation between consumption of animal fat and increased mean values of systolic blood pressure as well as between reduced consumption of salt, and glucose and diastolic blood pressure. This specific aspect is difficult to evaluate on the basis of the information provided by the participant. As significant cardiovascular risk factors were evinced, implementation of educative actions is suggested, aiming at the development of physical activities and proper dieting. Keywords: Keywords: Keywords: Keywords: Keywords: Hypertension; risk factor; occupational health; work. RESUMEN: RESUMEN: RESUMEN: RESUMEN: RESUMEN: Estudio transversal con objetivo de investigar los factores de riesgo cardiovascular en trabajadores de autobús y analizar la relación de los valores de la presión arterial y glucemia con los demás factores de riesgo. Desarrollado en Fortaleza-Ceará-Brasil, en 2005, mediante entrevista y evaluación antropométrica, de la glucemia y medida de la presión arterial con 124 motoristas y 96 cobradores. Los resultados demostraron que 49,2% presentaba valores d...

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Influence of caffeine on blood pressure and platelet aggregation

Abstract: The data suggest that caffeine increases diastolic blood pressure at the beginning of caffeine intake. This hypertensive effect disappears with chronic use. The absence of alterations in platelet aggregation indicates the need for larger randomized studies.

Cited by 23 publications

References 7 publications

Metabolites in stored platelets associated with platelet recoveries and survivals

Metabolites in stored platelets associated with platelet recoveries and survivals

Anti-Platelet Aggregation and Anti-Cyclooxygenase Activities for a Range of Coffee Extracts (Coffea arabica)

Prevalência e fatores associados à hipertensão em trabalhadores do transporte coletivo urbano no Brasil

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