Participação do estado contrátil e do relaxamento miocárdico na disfunção ventricular durante a transição hipertrofia-falência cardíaca

Cicogna, Antônio Carlos; Robinson, Kathleen G.; Conrad, Chester H.; Squire, Robin; Okoshi, Marina Politi; Bing, O.

doi:10.1590/s0066-782x1997001200003

Cited by 4 publications

(3 citation statements)

References 15 publications

(28 reference statements)

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“…One day after the performance of echocardiography, corresponding to 21 weeks, the animals were sacrificed while under anesthesia with sodium pentobarbital. At this time, signs of heart failure were identified, according to Conrad et al 39 and Cicogna et al 11,18 as tachypnea, pleuropericardial effusion, ascites, and the presence of left atrial thrombus.…”

Section: Methodsmentioning

confidence: 99%

Follow-up study of morphology and cardiac function in rats undergoing induction of supravalvular aortic stenosis

Ribeiro¹,

Okoshi²,

Cicogna³

et al. 2003

Arq. Bras. Cardiol.

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Section: Methodsmentioning

confidence: 99%

Follow-up study of morphology and cardiac function in rats undergoing induction of supravalvular aortic stenosis

Ribeiro¹,

Okoshi²,

Cicogna³

et al. 2003

Arq. Bras. Cardiol.

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“…During this period, the cardiac output returns to normal values, but the increase in BP is sustained, and due to the increase in total peripheral resistance (9) . In the temporal course of the pressure, the animal develops gradually SHR (between 6 and 24 months of age) cardiac morphological changes associated with the development of left ventricular hypertrophy (LVH), (10) which can assist in the maintenance of normal cardiac function, despite high systemic BP (11,12) . That genetic hypertension model is now very well documented the presence of sympathetic hyperactivity (13) and the renin-angiotensin system (RAS) (14) .…”

Section: Spontaneously Hypertensive Rats (Shr)mentioning

confidence: 99%

Effects of aerobic exercise training in animal models of hypertension.

Palma¹,

Malfitano²,

Shimojo³

et al. 2015

mtprehabjournal

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Background: Hypertension is one of the leading causes of death due to stroke, heart attack and kidney failure. The understanding of the pathophysiological mechanisms involved in its development and maintenance is critical to potential therapeutic interventions. Thus, animal models of hypertension have been used in the study of this disease for many years. Objective: To investigated the effects of dynamic aerobic exercise training as a non-pharmacological approach for the management of hypertension in animal models. Method/Design: This study is a literature review conducted in the Medline database. Results: The results demonstrated that aerobic exercise training may reduce blood pressure in different rat models of hypertension. Conclusions: The dynamic aerobic exercise can reduced blood pressure in different animal models of hypertension by mechanisms that involving neurohumoral changes, reinforcing the important role of this approach in the treatment of hypertension and its associated disorders.

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“…A técnica que utiliza o músculo papilar isolado do ventrículo esquerdo, realizada rotineiramente em nosso laboratório, (90)(91)(92) avalia a função mecânica do miocárdico in vitro. Esta preparação permite detectar alterações precoces na contração e no relaxamento do músculo cardíaco, (92) …”

Section: 92-função Miocárdica In Vitro -Músculo Papilar Isoladounclassified

Influência da oxidação de glicose sobre a função miocárdica de ratos obesos

Campos¹

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EPÍGRAFE ´1HQKXP YHQWR VRSUD D IDYRU GH TXHP QmR VDEH SDUD RQGH LUµ 6rQHFD RESUMOObesidade é uma doença metabólica crônica definida pelo acúmulo excessivo do tecido adiposo em relação à massa magra tecidual. Estudos clínicos mostram que a obesidade está associada à disfunção ventricular diastólica e não consistente comprometimento do desempenho sistólico. Os modelos experimentais que induzem obesidade por dietas têm sido utilizados como alternativa para se estudar as conseqüências das anormalidades cardíacas decorrentes do acúmulo de gordura.Pesquisas mostram que a função cardíaca em animais obesos pode estar preservada, diminuída ou aumentada. Alterações nos substratos energéticos, inibição da via glicolítica pelos ácidos graxos e redução na atividade da enzima piruvato desidrogenase (PDH) podem contribuir para a disfunção cardíaca induzida pela obesidade. Em razão da ausência de pesquisas que avaliaram a relação entre função cardíaca e metabolismo energético na obesidade, o objetivo deste estudo foi testar a hipótese que o desequilíbrio energético miocárdico, entre ácidos graxos e glicose, ocasionado pela obesidade, acarreta disfunção cardíaca. O prejuízo funcional nos animais obesos é decorrente de déficit de adenosina trifosfato (ATP), via glicolítica, para a bomba de cálcio (Ca 2+ ) do retículo sarcoplasmático (SERCA2). Wistar rats were assigned to one of two groups (n=30 each): control (C) and obese (Ob). The C group was fed a standard diet and Ob group was fed cycles of four highfat diets for 30 weeks. The total body fat was measured from the sum of the individual fat pad weights (epididymal, retroperitoneal and visceral) and the obesity defined by adiposity index. The nutritional and metabolic profiles of these animals were also evaluated. The cardiac remodeling process was assessed by structural and functional analysis. The structure was analyzed post-death for macroscopic study.Myocardial performance of isolated papillary muscle from the left ventricle (LV) was evaluated by under baseline conditions and after inotropic maneuvers. Comparisons between experimental groups (control and obese rats) were performed using Students-t test for independent samples. The cardiac function, after inotropic maneuvers, was analyzed by two-way analysis of variance (ANOVA) for repeated measures and complemented by Student-Newman-Keuls's posthoc test for specific differences. The level of significance considered was 5 %. Obesity promoted glucose intolerance, hyperinsulinemia, hyperleptinemia and insulin resistance after 30 weeks.However, the behavior of systolic blood pressure was similar between groups. The post-death macroscopic study showed that obesity doesn't promote to an increase in heart weight and heart chambers at 30 weeks. Obesity did not cause myocardial stiffness and damage on cardiac function under baseline conditions. Several inotropic maneuvers no make evident changes between control and obese, since the behavior of developed tension (DT) was similar between the groups. The return values of DT and resting ...

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Participação do estado contrátil e do relaxamento miocárdico na disfunção ventricular durante a transição hipertrofia-falência cardíaca

Cited by 4 publications

References 15 publications

Follow-up study of morphology and cardiac function in rats undergoing induction of supravalvular aortic stenosis

Follow-up study of morphology and cardiac function in rats undergoing induction of supravalvular aortic stenosis

Effects of aerobic exercise training in animal models of hypertension.

Influência da oxidação de glicose sobre a função miocárdica de ratos obesos

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