BackgroundChagas disease is a cause of dilated cardiomyopathy, and information about left
atrial (LA) function in this disease still lacks.ObjectiveTo assess the different LA functions (reservoir, conduit and pump functions) and
their correlation with the echocardiographic parameters of left ventricular (LV)
systolic and diastolic functions.Methods10 control subjects (CG), and patients with Chagas disease as follows: 26 with the
indeterminate form (GI); 30 with ECG alterations (GII); and 19 with LV dysfunction
(GIII). All patients underwent M-mode and two-dimensional echocardiography,
pulsed-wave Doppler and tissue Doppler imaging.ResultsReservoir function (Total Emptying Fraction: TEF): (p <0.0001), lower in GIII
as compared to CG (p = 0.003), GI (p <0.001) and GII (p <0.001). Conduit
function (Passive Emptying Fraction: PEF): (p = 0.004), lower in GIII (GIII and
CG, p = 0.06; GI and GII, p = 0.06; and GII and GIII, p = 0.07). Pump function
(Active Emptying Fraction: AEF): (p = 0.0001), lower in GIII as compared to CG (p
= 0.05), GI (p<0.0001) and GII (p = 0.002). There was a negative correlation of
E/e’average with the reservoir and pump
functions (TEF and AEF), and a positive correlation of
e’average with s’ wave (both septal and lateral
walls) and the reservoir, conduit and pump LA functions.ConclusionAn impairment of LA functions in Chagas cardiomyopathy was observed.