Gas exchange during exercise in different evolutional stages of chronic Chagas' heart disease

Abstract

Objective -

Oxidative stress in chronic cardiopathy associated with Chagas disease

“…The decrease in catalase activity could be related to the increased anaerobic metabolism parallel to the increase in ventricular remodeling. Pedrosa et al [34], and Oliveira et al [35] showed that healthy subjects have better O 2 utilization per unit of body mass compared to late chagasic patients. It is well known that O 2 consumption is almost linear to O 2 U− and H 2 O 2 generation [38][39][40] and, therefore, diminished oxidative metabolism will render lower ROS production.…”

“…In accordance to [33], group II is characterized by higher intracellular lesions, inflammation and fibrosis compared to groups IA and IB, while in group III there is a greater incidence and greater severity of such abnormalities, indicating a direct correlation between these processes and the degree of cardiac remodeling. The modified Los Andes classification reviewed by Xavier [25] shows that the higher the degree of ventricular remodeling the higher the mortality, and some studies have used this classification for clinical evaluations [15,34,35]. Taken these clinical aspects into consideration, in the present study the patients were ranked according to the modified classification reviewed by Xavier [25], and also because it indicates the extensive cardiac damage in chronic chagasic patients.…”

Relationship between Fibrosis and Ventricular Arrhythmias in Chagas Heart Disease Without Ventricular Dysfunction

“…Regarding the TET, only the tests of patients reaching 7 MET, limit defined as a submaximal exercise level (good correlation between the anaerobic threshold achieved and the 7-MET load achieved), were considered for analysis 11 . Two observers analyzed and compared the ECGs at rest and during exercise (around 7 MET), identifying in both situations the 30-second period with the greatest number of ventricular arrhythmias and/or NSVT episodes.…”

Neuromuscular electrical stimulation in a patient with chronic heart failure due to chagas disease: a case report

“…The functional capacity of patients in the initial phase of chronic Chagas heart disease is higher than those in advanced phases 11. …”